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Experts consensus on diagnostic and therapeutic strategies for malocclusions at early developing stage FANG Bing, JIN Zuo-lin, BAI Yu-xing, WANG Lin, ZHAO Zhi-he, LI Wei-ran, BAI Ding, HE Hong, LIU Yue-hua, HU Min, SONG Jin-lin, CHEN Li-li, CAO Yang, WU Ting-xi, LI Song, LI Huang, SHI Jie-jun, CHU Feng-ting Shanghai Journal of Stomatology    2021, 30 (5): 449-455.   DOI: 10.19439/j.sjos.2021.05.001 Abstract （2148）      PDF （861KB）（9617）       Knowledge map    Early orthodontic intervention remains a controversial notion in current dental care regime. Whilst early orthodontic treatment for children is the province for orthodontic specialists, a growing number of general practitioners, who may not possess sufficient specialty knowledge, are also involved, raising the concerns about the propriety and quality of their treatment modalities. However, orofacial development of children and adolescents is in a very complicated environment. Comprehensive theoretical knowledge and a great wealth of practical experience are required to ensure the final treatment effect. The possible complications should be kept under control and fully informed to patients and their parents. In order to unify and standardize early orthodontic treatment protocol and help to promote healthy and orderly development of early orthodontic treatment, this consensus summarized the practical experience of orthodontic experts from many famous colleges and affiliated hospitals for clinical reference. Reference | Related Articles | Metrics

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Clinical analysis of chronic nonbacterial osteomyelitis involving the mandible in 35 adolescents Wang Hanshao, Wang Yiwen, Wei Wenbin, Huo Liang, Li Jiang, Chen Minjie Shanghai Journal of Stomatology    2025, 34 (5): 483-489.   DOI: 10.19439/j.sjos.2025.05.006 Abstract （366）      PDF （2022KB）（4086）       Knowledge map    PURPOSE: To summarize and analyze the clinicopathological features of chronic nonbacterial osteomyelitis (CNO) in adolescents, and to provide opinions for better diagnosis and treatment of the disease. METHODS: A retrospective study was conducted on adolescent patients diagnosed with CNO in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from September 2013 to December 2023. The demographic data, laboratory examination, imaging examination, pathological manifestations and treatment results of the patients were summarized. Clinical symptom evaluations, laboratory tests and imaging examinations were used to evaluate the effect of clinical treatment. RESULTS: Thirty-five patients were included, including 14 males and 21 females, with a male to female ratio of 1∶1.5. 45.7% patients had multiple lesions. Diagnoses prior to diagnosis of CNO included fibrous dysplasia, parotitis, infectious osteomyelitis and idiopathic arthritis. Abnormal increases in laboratory test indicators included white blood cells (20%), erythrocyte sedimentation rate (60%), C-reactive protein (40%), interleukin-6 (22.9%) and so on. CT findings showed osteolytic, sclerosing and hyperostosis. Bone scans showed multiple lesions in 5 patients. In drug therapy, the effective rate of NSAIDs and DMARDs exceeded 50%. CONCLUSIONS: Interleukin-6 is elevated in some CNO patients, and its relationship with pathogenesis needs to be further studied. The recurrence rate of decortication is high, and drug therapy may be more effective than surgical treatment. Reference | Related Articles | Metrics

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Grade Ⅳ myelosuppression after induction chemotherapy of TPF on oral cancer: clinical analysis of 29 cases JIN Jing, YE Mao-chang, WANG Lai-ping, LI Rong-xin, ZHOU Yu, WANG Yi, ZHU Wei-zheng, ZUO Yan, LIU Shou-hong Shanghai Journal of Stomatology    2014, 23 (2): 219-223.   Abstract （579）   HTML （0）    PDF （674KB）（4358）       Knowledge map    PURPOSE: To observe and evaluate the clinical features and treatment strategies of IV myelosuppression after induction chemotherapy of oral mucosa squamous cell carcinoma under conventional dosage. METHODS: Twenty-nine patients of oral mucosa squamous cell carcinoma pathologically diagnosed between 2006 and 2012 were enrolled into this study. The patients received induction chemotherapy with docetaxel-cisplatin-5-fluorouracil (TPF) and suffered from grade IV myelosuppression. Regulations and treatment strategies of the bone marrow myelosuppression were analyzed, retrospectively. RESULTS: Twenty-nine cases had bone marrow suppression 9-14 days after induction chemotherapy, and the median time was 10 days, with a "U"-shaped fluctuation pattern. There were 26 cases with colony-stimulating factor(CSF) therapy completing treatment according to the schedule and 2 cases were required to radiotherapy because of unsatisfied effect of CSF therapy. One case died and the death rate after chemotherapy was 0.68% in this group. CONCLUSIONS: The incidence of grade IV myelosuppression is normal and fatal. This study shows the starting time of the "U"-shaped fluctuation and the necessaries of adding CSF therapy at the same time. The emergency treatment of myelosuppression should be used including single disinfected ward mouthwash and therapy of CSF drug. Reference | Related Articles | Metrics

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Research progress and current situation of oral surgery robots based on published papers and patents analysis ZHANG Zhi-fan, SHU Zhi-qun, XU Feng, SHEN Hui-qing Shanghai Journal of Stomatology    2025, 34 (1): 106-112.   DOI: 10.19439/j.sjos.2025.01.019 Abstract （674）      PDF （1440KB）（2856）       Knowledge map    PURPOSE: To analyze the research progress and technological development of oral surgery robots, reveal the future development trend of oral surgery robots and put forward policy suggestions. METHODS: Focusing on the topic of oral surgery robots, literature review and patent data retrieval methods were used to analyze data from 2011 to 2023 from the perspectives of quantity, source, and technical field. RESULTS: The number of academic papers and patent applications in the field of oral surgery robots had explosive growth since 2015. The literature mainly focused on topics such as oral implantation and digitalization, with Chinese scholars publishing the most papers. The patents focused on tools such as models and instruments dedicated to oral surgery, as well as technical fields such as implant visual navigation and positioning systems. CONCLUSIONS: Oral surgery robots should be developed towards miniaturization and specialization in the future, and domestic breakthroughs in core technologies such as special instruments need to be accelerated. Reference | Related Articles | Metrics

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Genistein loaded by PRF improved bone healing in obese mice ZHANG Xue-bing, LI Qi Shanghai Journal of Stomatology    2024, 33 (1): 13-21.   DOI: 10.19439/j.sjos.2024.01.003 Abstract （519）      PDF （1721KB）（2172）       Knowledge map    PURPOSE: To clarify the effect of genistein(GEN) on osteogenic differentiation and explore the effect of GEN loaded by platelet-rich fibrin (PRF) on the repair process of bone defects in obese mice. METHODS: In in vitro experiments, the effect of GEN(0, 0.1, 1, 10, 50 μmol/L) on the proliferation of mouse embryonic osteoblast precursor cells (MC3T3-E1) was determined by CCK 8. Alkaline phosphatase(ALP) staining and quantitative detection of ALP activity were performed to determine the changes of ALP activity in cells; RNA and protein expression levels of ALP, osteopontin (OPN) and osteocalcin (OCN) were detected by quantitative real-time PCR(qRT-PCR) and Western blot. Alizarin red staining was used to define the effect of GEN on mineralization of MC3T3-E1. To verify the feasibility of the PRF drug loading, the ultrastructure of PRF was subsequently observed under SEM. In in vivo experiments, obese C57 mouse models were established by high-fat diet feeding. On this basis, skull defect models with a diameter of 2.8 mm were established, and the prepared GEN/PRF complexes were placed into the bone defect area. The effects of GEN on skull defect repair in obese mice were evaluated by Micro-CT scanning and hematoxylin-eosin(H-E) staining. Statistical analysis was performed with GraphPad Prism 5.0 software package. RESULTS: CCK 8 results showed that 0.1, 1 μmol/L GEN promoted cell proliferation within 7 days(P<0.05); 10 μmol/L GEN had no significant effect on the process of cell proliferation. From the second day, 50 μmol/L GEN significantly inhibited cell growth and showed cytotoxicity(P<0.05). These two concentrations had similar effects in promoting cellular osteogenic differentiation. SEM results showed that PRF presented a 3-dimensional network structure, providing space for loading drug molecules. In in vivo experiments, the body weight of mice in the high-fat diet (HFD) group was 27.7% greater than that in the normal diet group(P<0.05) and had abnormal glucose tolerance (P<0.05). Micro-CT showed that compared with the normal diet group, the number of bone trabeculae in the femur of obese mice was decreased(P<0.05), the distance between bone trabeculae was widened(P<0.05), and the bone density was decreased (P<0.05). In addition, GEN (0.1, 1.0 μmol/L) loaded by PRF increased bone volume fraction in the skull of obese mice (P<0.05). H-E results showed that GEN/PRF promoted the healing of the bone defects. CONCLUSIONS: GEN promotes osteogenic differentiation of MC3T3-E1, and it can effectively accelerate the healing of cranial bone defects after loading with PRF in obese mice. Reference | Related Articles | Metrics

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Proteomic analysis of dental pulp serum in pulpitis at different stages Sui Xin, Xu Huaxing, Li Jiayang, Qin Zhiming, Ma Zhifei, Zhou Rongrui, Zhou Qiangqiang, Wei Xiaoling Shanghai Journal of Stomatology    2025, 34 (4): 346-353.   DOI: 10.19439/j.sjos.2025.04.002 Abstract （357）      PDF （1732KB）（1841）       Knowledge map    PURPOSE: To investigate the differentially expressed proteins in dental pulp serum of pulpitis at different stages. METHODS: Dental pulp serum was collected from 9 pulpitis patients and categorized into three groups: initial pulpitis (IP), mild to moderate pulpitis (MP) and severe pulpitis (SP). Proteomics technology was utilized to screen for differentially expressed proteins. Functional annotation and enrichment analysis were then conducted using the Metascape database, while protein-protein interaction analysis was performed with the STRING database. RESULTS: Compared with the IP group, the MP group had 20 upregulated proteins and 23 downregulated proteins, while the SP group had one upregulated protein and 44 downregulated proteins. Compared to the MP group, the SP group had 9 upregulated proteins and 15 downregulated proteins. The differential proteins were mainly involved in key biological processes such as cellular response to stress, adaptive immune response, and the Parkin-ubiquitin proteasomal system. Protein-protein interaction network analysis identified several key functional nodes, including CCT6A. CONCLUSIONS: This study analyzed the differential expression of proteins in dental pulp serum between early, mild to moderate, and severe pulpitis, providing a theoretical basis for accurate diagnosis and clinical decision-making of pulpitis. Reference | Related Articles | Metrics

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Comparison of aesthetic effect between immediate and delayed implant restoration of single maxillary anterior tooth Liu Bingyao, Yu Yue, Wu Yingying, He Maodian, Zhang Fangqi Shanghai Journal of Stomatology    2025, 34 (4): 387-391.   DOI: 10.19439/j.sjos.2025.04.008 Abstract （427）      PDF （548KB）（1748）       Knowledge map    PURPOSE: To compare the aesthetic effects of immediate implant restoration and delayed implant restoration of single maxillary anterior tooth. METHODS: A total of 163 patients who underwent single anterior tooth implantation in the maxilla at Taikang Xianlin Drum Tower Hospital from January 2020 to May 2023 were selected. They were divided into immediate implant restoration group(n=75) and delayed implant restoration group(n=88). In the immediate implant restoration group, a temporary implant was installed and implanted immediately after extraction, while in the delayed implant restoration group, the implant was implanted 3-6 months after extraction and repaired after the implant was stabilized. The outcomes, including implant success rate, soft tissue aesthetics, implant stability, aesthetic outcomes, periodontal health, pink esthetic score (PES), white esthetic score (WES), bone resorption after 12 months and subjective satisfaction were compared between the two groups. RESULTS: After exclusion, totally 62 patients in the immediate implant restoration group and 64 patients in the delayed implant restoration group were included in the analysis. Both groups had a 100% implant success rate with no significant difference between the two groups(P>0.05). The immediate implant restoration group was significantly better in terms of soft tissue aesthetics and implant stability compared to the delayed implant restoration group(P<0.05). Aesthetic effect scores for the immediate implant restoration group were significantly higher than those of the delayed group at 1, 3, 6 and 12 months postoperatively(P<0.05). The periodontal tissue health of the immediate implant restoration group was significantly better than that of the delayed group at various time points(P<0.05). PES and WES scores of immediate implant restoration group were significantly better than those of the delayed group(P<0.05). At 12 months after surgery, bone resorption in the immediate implant restoration group was significantly lower than that in the delayed group, subjective satisfaction score was significantly higher than that in the delayed group(P<0.05), and there was no significant difference in color satisfaction between the two groups(P>0.05). CONCLUSIONS: Immediate implant restoration of maxillary single anterior teeth is superior to delayed implant restoration in soft tissue aesthetic effect, implant stability and patient satisfaction, which is suitable for patients with high aesthetic requirements. Reference | Related Articles | Metrics

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Clinical efficacy of the combination of miniscrew with clear aligner in controlling the roller coaster effect MA Xiao-qing, XIANG Fei, FAN Ming-yue, SONG Yi, WANG Xiao-hui, ZHANG Ling, QIAN Wen-hao Shanghai Journal of Stomatology    2022, 31 (2): 193-197.   DOI: 10.19439/j.sjos.2022.02.015 Abstract （1314）      PDF （1173KB）（2508）       Knowledge map    PURPOSE: To investigate the clinical efficacy of miniscrew in controlling the roller coaster effect in long-distance space closure with clear aligner. METHODS: Sixteen adult patients with bimaxillary protrusion were selected. All cases were treated with clear aligner and their four first premolars were extracted. G6 was designed in all cases. In the experimental group, four miniscrews were inserted at the beginning of treatment to control the teeth in three dimensions; while in the control group, the miniscrews were not applied until obvious roller coaster effect appeared. Paired t test was used to analyze the data with Graphpad Prism 6.0 software package. RESULTS: All the extraction space was closed successfully and the lateral profile was improved significantly. The torque of the upper incisor was under well control and no roller coaster effect happened in the experimental group; while in the control group, the lingual inclination of the upper incisors and open bite of the posterior teeth developed(P<0.05). After the miniscrews intrusion of the upper anterior teeth, the occlusion relationship improved significantly. CONCLUSIONS: Miniscrews effectively prevents and eliminates the roller coaster effect in the process of long-distance space closure with clear aligner. Reference | Related Articles | Metrics

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A retrospective study on clinical outcomes of implant-supported rehabilitations in patients with alveolar cleft Lan Rong, Wu Yiqun, Huang Wei, Chen Zhenqi, Pan Xiaogang, Wang Feng Shanghai Journal of Stomatology    2025, 34 (3): 326-331.   DOI: 10.19439/j.sjos.2025.03.018 Abstract （393）      PDF （921KB）（1649）       Knowledge map    PURPOSE: To retrospectively evaluate the clinical outcomes of implant-supported prosthesis in alveolar cleft patients. METHODS: A total of 14 patients with alveolar cleft underwent implant restoration in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2015 to January 2023 were collected. Among them, 9 were male and 5 were female. The age ranged from 18 to 52 years, with a mean of (26.1±10.6) years. The sequence treatment history of patients with cleft lip and palate and the effect of implant repair were retrospectively analyzed. RESULTS: Bone grafting in the fissured area failed repeatedly in 1 patient and no implant was implanted. A total of 21 implants were implanted in the remaining 13 patients with alveolar cleft, all of which achieved good osseointegration. In 10 cases, one implant was implanted in each fissure area for single crown or single end bridge repair. In 3 cases, 11 implants were implanted in the non-fissure area for fixed bridge repair. Seven patients with single implant were followed up for 6 to 96 months, with an average of (39.4±29.2) months. During their visits, patients underwent various examinations, including pink aesthetic score (PES) averaging 10.16±0.98, white aesthetic score(WES) averaging 8.50±1.23, and probing depth(PD) with a mean of (2.68±0.61) mm. Additionally, gingival index(GI) was recorded with a mean of 1.33±1.10, and marginal bone loss(MBL) was measured with a mean of (0.17±0.35) mm. The width of the mid-labial keratinized mucosa was observed to be (5.14±2.10) mm. CONCLUSIONS: Implant-supported prosthesis in the alveolar cleft area after well-established multidisciplinary sequential treatments have predictable middle-term success rate, satisfactory aesthetic outcomes and stable peri-implant soft and hard tissue conditions. Reference | Related Articles | Metrics

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Nonradiological methods for implant surgical guide accuracy measurement YE Sheng-jia, BAO Shi-jie, CHEN Qu-yi, XIN Xian-zhen, DONG Jian-hui, WEI Bin Shanghai Journal of Stomatology    2021, 30 (5): 467-471.   DOI: 10.19439/j.sjos.2021.05.004 Abstract （603）      PDF （717KB）（2023）       Knowledge map    PURPOSE: To evaluate the accuracy of static computer-navigated implantation with surgical guides, based on a non-radiological method. Traditional measurements with a second cone-beam CT (CBCT) were applied to verify the accuracy. METHODS: A total of thirty template-guided implantations were designed and performed on 15 resin models. Two paralleled bone-level implants were planned in the edentulous space of each model, between which the distance was 4 mm. Postoperative implant positions were detected with both CAD/CAM-based measurements applying an intraoral scanner (3Shape TRIOS) and traditional ways via CBCT. Both methods were conducted with a CAD quality-control, reverse engineering software, Geomagic Studio 2013, comparing the positions with the virtual ones. Statistical analysis was processed with SPSS 23.0 software package. RESULTS: Measurements using CBCT (control group) showed a trend toward greater deviations when the results were directly compared(P<0.05). In the CAD/CAM-based evaluation of the 30 samples, the mean deviation of the insertion axis from the planned implant axis was 1.134°. The mean deviations of the implant shoulders in the horizontal direction and at the implant apices were 0.447 mm and 0.557 mm, respectively. No significant difference was observed when measuring distance deviation with the two assessment ways. CONCLUSIONS: Compared with evaluation based on radiology, CAD/CAM based evaluation system is able to evaluate implant accuracy precisely, effectively reduce radiological exposure of patients, being suitable for clinical evaluation. Reference | Related Articles | Metrics

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Metabolomics study on the difference of tongue coating metabolites between patients with intra-oral halitosis and healthy individual LIMAN Aviella-nathania, ZHU Hong-lai, YANG Wen-jie, YE Wei Shanghai Journal of Stomatology    2023, 32 (5): 525-531.   DOI: 10.19439/j.sjos.2023.05.014 Abstract （617）      PDF （1306KB）（2114）       Knowledge map    PURPOSE: To analyze the difference of metabolites of tongue coating between patients with intra-oral halitosis and healthy individuals by untargeted metabolomics, and to explore significant differences in metabolites of intra-oral halitosis as biomarkers. METHODS: The untargeted metabolomics of tongue coating samples from 12 patients with intra-oral halitosis and 12 healthy individuals were studied by liquid chromatography and mass spectrometry combined with principal component analysis and orthogonal partial least squares discriminant analysis. The value of variable importance in projection >1 and P<0.05 of Student's t test in the orthogonal partial least squares-discriminant analysis model were used as the criteria to screen and determine the differential metabolites. RESULTS: There were differences in the metabolites of tongue coating between patients with intra-oral halitosis and healthy individuals, and 11 different metabolites were identified. They were valyl-arginine, glycine-phenylalanine, tryptophyl-proline, deoxyadenosine, 4,5-dihydroniveusin A, N-acetyl-DL-tryptophan, paramethasone acetate, cyclopentanol, [(2-hexylcyclopentylidene) amino]thiourea, L-pipecolic acid and taurine. In the intra-oral halitosis group, the expressions of Glycine-phenylalanine and N-acetyl-DL-tryptophan were significantly up-regulated, while the expressions of taurine were significantly down-regulated. CONCLUSIONS: There are differences in the metabolites of tongue coating between patients with intra-oral halitosis and healthy individuals. The differential metabolites with diagnostic value may be used as diagnostic markers of intra-oral halitosis. Reference | Related Articles | Metrics

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Shanghai Journal of Stomatology    2012, 21 (3): 344-349.   Abstract （302）      PDF （786KB）（1758）       Knowledge map    Related Articles | Metrics

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Application of metronidazole combined with minocycline in reducing infection after dental implant in patients with localized periodontitis ZHANG Shi-kun, PEI Dong-dong, JIANG Dan-dan, ZHANG Li-hua, CAI Jian-ying, CHANG Zhong-fu Shanghai Journal of Stomatology    2023, 32 (5): 532-535.   DOI: 10.19439/j.sjos.2023.05.015 Abstract （741）      PDF （505KB）（1692）       Knowledge map    PURPOSE: To explore the value of metronidazole combined with minocycline in reducing infection after dental implant in patients with localized periodontitis. METHODS: A total of 120 patients with localized periodontitis who underwent dental implantation in the Department of Stomatological, Shanghai Pudong New Area People's Hospital from August 2021 to September 2022 were selected. According to the way of postoperative infection prevention, the patients were divided into control group and experimental group, with 60 patients in each group. The control group was orally given roxithromycin capsules, and the experimental group was locally coated with minocycline hydrochloride ointment and metronidazole gel. The incidence of postoperative infection and complications was compared between the two groups. The modified gingival creval bleeding index (mSBI), periodontal probing depth (PD) and modified plaque index (mPLI) of the patients were examined by periodontal probe. Serum C-reactive protein (CRP) level was determined by immunoturbidimetry and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) level was determined by ELISA. SPSS 25.0 software package was used for statistical analysis of the data. RESULTS: Good healing rate of the experimental group was 91.67% higher than that of the control group 73.33%, postoperative infection rate was 8.33% and complication rate was 6.67% in the experimental group, significantly lower than that of the control group (26.67% and 20.00%), respectively (P<0.05). After treatment, the level of CRP, TNF-α and IL-6 in the experimental group were significantly lower than those in the control group (P<0.05). At 3 and 6 months after treatment, mSBI, mPLI and PD in the experimental group were significantly lower than those in the control group(P<0.05). CONCLUSIONS: The administration of minocycline hydrochloride and metronidazole in patients with localized periodontitis undergoing implantation can reduce oral inflammatory response, reduce postoperative infection and other complications, and improve periodontal health. Reference | Related Articles | Metrics

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Effect and mechanism of digital cobalt-chromium alloy porcelain crowns and zirconia all-ceramic crowns restoration on periodontal health of patients with tooth defects Adilijiang·Yimiti, Sui Meizhi, Abudureyimujiang·Ku'erban, Li Fei, Liao Qian Shanghai Journal of Stomatology    2025, 34 (5): 496-503.   DOI: 10.19439/j.sjos.2025.05.008 Abstract （372）      PDF （1935KB）（1314）       Knowledge map    PURPOSE: To investigate the impact and underlying mechanisms of digital cobalt-chromium alloy porcelain crowns and zirconia all-ceramic crowns restoration on periodontal health in patients with tooth defects. METHODS: A total of 26 patients with tooth defects who were treated in the Second People's Hospital of Kashi Region from March to June 2024 were selected and randomly divided into cobalt-chromium alloy ceramic crown group (n=13) and zirconia all-ceramic crown group (n=13). After 6 months of restoration, the periodontal health status of the two groups was evaluated, including gingival index, gingival bleeding index, plaque index, caries loss index and loss of clinical attachment. In addition, clinical plaque samples from patients were collected for 16S rRNA sequencing and data analysis to compare the characteristics of different flora in the two groups of samples. The samples of gingival crevicular fluid were collected and proteomic analysis was used to screen the differentially expressed proteins, and the biological process and functional pathway of their enrichment were discussed. RESULTS: After 6 months of restoration, the gingival index, plaque index, and caries loss and repair index in the zirconia all-ceramic crown group were significantly lower than those in the cobalt-chromium porcelain crown group (P<0.05). Although there was no significant difference in the α-diversity indexes of the plaque samples between the two groups, significant differences were observed in the microbial composition: Scardovia, Granulicatella, and Eikenella were significantly enriched in the zirconia all-ceramic crown group, while Peptococcus and Treponema were enriched in the cobalt-chromium porcelain crown group. In addition, a total of 105 differentially expressed proteins were identified by proteomic analysis, and these differentially expressed proteins were significantly enriched in metabolic related biological processes and functional pathways such as fatty acid metabolism and amino acid metabolism. CONCLUSIONS: Zirconia all-ceramic crowns are superior to cobalt-chromium alloy porcelain crowns in terms of periodontal health for patients with dental defects, with less detrimental impact on oral microbiome, suggesting that zirconia crowns have a high clinical application value. The discovery of differential bacteria and differential expressed proteins provides potential biomarkers for early prediction of periodontal diseases and the development of personalized treatment plans. Reference | Related Articles | Metrics

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The impact of oral occlusal exercises on occlusal performance of oral cancer patients following segmental mandibulectomy without simultaneous reconstruction Yang Ling, Zhou Tian, Zhao Ning, Qu Xingzhou, Chen Weihong, Zhao Yan, Hou Lili Shanghai Journal of Stomatology    2025, 34 (2): 184-190.   DOI: 10.19439/j.sjos.2025.02.013 Abstract （374）      PDF （1111KB）（1658）       Knowledge map    PURPOSE: To investigate the effects of oral occlusion exercises on occlusal performance of oral cancer patients who underwent segmental mandibular resection without simultaneous reconstruction. METHODS: From October 2022 to May 2023, a total of 63 oral cancer patients who underwent segmental mandibular resection without reconstruction at the Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were selected. They were randomly divided into control group (30 patients) and experimental group (33 patients). The control group received conventional care, while the experimental group underwent oral occlusion exercises except conventional care. After three months, the maximum total occlusal force(TOF), asymmetry index of occlusal force(AOF), center of occlusal force(COF), and mastication efficiency of both groups were compared. Statistical analysis was conducted using SPSS 26.0 software package. RESULTS: Compared with the control group, TOF in the experimental group was increased, AOF and COF were decreased, and the differences were statistically significant(P<0.01). The masticatory efficiency of the experimental group was significantly better than that of the control group(P<0.01). CONCLUSIONS: Oral occlusal exercises can improve occlusal performance in patients with mandibular resection without reconstruction, but larger sample size and rigorous design are needed to further verify its clinical effect and mechanism. Reference | Related Articles | Metrics

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Investigation of postoperative xerostomia and contributory factors in patients with oral cancer Guo Xingtong, Hou Lili Shanghai Journal of Stomatology    2026, 35 (1): 88-94.   DOI: 10.19439/j.sjos.2026.01.015 Abstract （209）      PDF （747KB）（1306）       Knowledge map    PURPOSE: To analyze the current status of postoperative xerostomia in patients with oral cancer and the contributory factors. METHODS: A total of 140 patients undergoing oral cancer surgery in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from March 2022 to November 2022 were selected as the study objects. The Numberical Rating Scale(NRS) and Unstimulated Saliva Flow Rate(USFR) were used to assess the degree of oral dryness. Thirst level was assessed using the Thirst Distress Scale(TDS). The quality of life and psychological status of patients were evaluated by Quality of Life Questionnaire-the Head and Neck Cancer Module (QLQ-H&N35) and Self-rating Anxiety Scale. The influence factors of NRS and USFR were analyzed by univariate and multifactorial regression. RESULTS: The results of multifactorial analysis showed that in terms of dry mouth severity, patients more than 60 years old had higher NRS scores than those less than 60 years old(β=-0.133, P<0.001). Bilateral removal of submandibular gland had higher NRS score than those with unresected/unilateral submandibular gland removal(β=-0.139, P=0.002). Patients with tracheotomy had higher NRS score than those without tracheotomy(β=-0.104, P=0.007). The higher NRS scores for postoperative abstinence from drinking for five days or more(β=-0.099,P=0.002), higher NRS scores for open-mouth breathing(β=-0.103,P=0.006). Higher postoperative QLQ-H&N35(β=0.007,P<0.001) and TDS(β=0.112,P<0.001) scores were associated with more severe oral dryness. USFR was lower in females compared to males(β=0.009, P=0.045), patients with a history of alcohol consumption(β=-0.018, P=0.002), patients treated with preoperative chemotherapy(β=0.015, P=0.006), patients with more than 11h of preoperative abstinence from drinking(β=0.02, P=0.001), and tracheotomized patients(β=-0.011, P=0.048). Patients with lower preoperative USFR had lower postoperative USFR(β=0.105, P<0.001), patients with higher TDS scores had a lower USFR(β=-0.006, P<0.001). CONCLUSIONS: Gender, age, submandibular gland removal, parotid duct ligation, tracheotomy, length of postoperative abstinence from drinking, open-mouth breathing, postoperative quality of life, and thirst affected patients' oral dryness and salivation. Healthcare professionals should recognize early and provide a basis for developing care measures to reduce oral dryness. Reference | Related Articles | Metrics

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Application of sliding vermilion flap in angulus oris defect after buccal mucosa cancer ablation Wu Kun, Wu Hanjiang Shanghai Journal of Stomatology    2025, 34 (2): 157-161.   DOI: 10.19439/j.sjos.2025.02.008 Abstract （311）      PDF （1469KB）（1819）       Knowledge map    PURPOSE: To evaluate the effect of sliding vermilion flap in angulus oris defect after buccal mucosal cancer ablation. METHODS: A total of 33 patients with buccal mucosal cancer who underwent buccal mucosal cancer radical surgery and resection of angulus oris, and reconstructed with free anterolateral thigh flap transfer and sliding vermilion flap were collected from January 2015 to April 2021 in Department of Oral and Maxillofacial Surgery at Second Xiangya Hospital. Thirty-three patients with buccal mucosal cancer admitted to Department of Oral and Maxillofacial Surgery, Second Xiangya Hospital of Central South University from January 2015 to April 2021 were selected. All patients underwent combined buccal-mandibulectomy and neck radical operation and resection of oral angle, and underwent anterolateral femoral free flap and lip red elastic flap reconstruction. The angulus oris outcome, aesthetics outcome, masticatory efficacy, swallowing and speech function were assessed by FACT-HN (The Functional Assessment of Cancer Therapy-Head and Neck). The mouth opening was measured and recorded. SPSS 19.0 software package was used for statistical analysis of the data. RESULTS: The success rate of free flap transplantation was 100% in 33 patients. Although the aesthetics outcome was decreased at postoperative 1 year compared with that of preoperative duration (P<0.001), there was no significant difference of angulus oris outcome at postoperative 1 year compared with that of preoperative duration (P>0.05). Moreover, the masticatory function was significantly improved at postoperative 1 year compared with that of preoperative duration(P=0.004). However, there was no significant difference of speech and swallowing function at postoperative 1 year compared with that of preoperative duration (P>0.05). The mouth opening was significantly improved at postoperative 1 year compared with that of preoperative duration(P<0.05), and the satisfaction of mouth opening in these patients was 75.7%. CONCLUSIONS: The use of sliding vermilion flap can ideally repair the angulus oris, and offer a novel method to reconstruct defect of angulus oris. Reference | Related Articles | Metrics

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Evaluation of the effect of cruciform tooth division and T-type crown amputation in extraction of mandibular middle and low impacted teeth Liu Jie, Wang Ying, Liu Zhenfei Shanghai Journal of Stomatology    2025, 34 (3): 271-275.   DOI: 10.19439/j.sjos.2025.03.009 Abstract （439）      PDF （592KB）（1512）       Knowledge map    PURPOSE: To evaluation the effect of cruciform tooth division and T-type crown amputation in extraction of mandibular middle and low impacted teeth. METHODS: A total of 81 patients with mandibular middle and low impacted teeth treated in Bozhou People's Hospital from September to November 2024 were selected. According to the different extraction methods,they were divided into the control group(n=40, T-type crown amputation) and experimental group(n=41, cross tooth extraction). The operative time, intraoperative complications(anxiety, broken root), postoperative complications (pain, swelling and restricted mouth opening), healing of tooth extraction socket 1 week after surgery, and quality of life before and 1 week after surgery[oral health impact scale 14(OHIP-14)] were compared between the two groups. RESULTS: The operative time of the experimental group was significantly shorter than that of the control group, the total incidence of intraoperative complications(4.88%) was significantly lower than that of the control group (20.00%), the score of postoperative pain and mouth opening restriction was significantly lower than that of the control group, the degree of postoperative swelling was significantly less than that of the control group, and the total incidence of postoperative complications(4.88%) was significantly lower than that of the control group(32.43%). The healing score of tooth socket 1 week after operation was significantly lower than that of the control group (P<0.05). One week after surgery,the OHIP-14 score of both groups was decreased,and the experimental group was significantly lower than the control group(P<0.05). CONCLUSIONS: Compared with T-type crown amputation, cruciform tooth division can shorten the operation time of mandibular middle and low impacted tooth extraction, reduce the occurrence of intraoperative anxiety, broken root, postoperative pain, swelling and restricted mouth opening, and is conducive to the healing of tooth extraction wound. Reference | Related Articles | Metrics

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Preliminary report of botulinum toxin type A injection at trigger point for treatment of trigeminal neuralgia：experiences of 16 cases WANG Shuang-yi, YUE-jin, XU Yao-xiang, XUE Ling-fa, XIAO Wen-lin, ZHANG Chun-yang Shanghai Journal of Stomatology    2014, 23 (1): 117-119.   Abstract （512）   HTML （0）    PDF （395KB）（1855）       Knowledge map    PURPOSE: To investigate the effects of injection of botulium toxin type A at trigger point for treatment of patients with primary trigeminal neuralgia. METHODS: Sixteen patients with primary Trigeminal Neuralgia were treated with injection of botulium toxin type A. Visual analog scores(VAS) at 1 week, 2 weeks, 1 month, 3months and 6 months after treatment and Barrow Neurological Institute (BNI) pain evaluation criteria were utilized to measure the degree of pain. The data was analyzed with SPSS 10.0 software package. RESULTS: The VAS score was 9.12±0.65 before botulium toxin type A injection while the scores were 2.8±1.36, 2.2±1.26, 1.3±1.45, 1.3±1.45 and 1.2±2.52 at 1 week, 2 weeks, 1 month,3 months and 6 months after treatment. There was significant difference in VAS compared with before treatment. VAS score was lower and stable at 1 month, 3 months and 6 months after treatment, but no significant difference was found at 1-week and 2-week after treatment. BNI evaluation results showed good therapeutic effect 1 week after treatment, while the best therapeutic effect was noted 1-3 months after treatment. 6 months later, 1 patient had recurrence and 11 patients had complete relief of pain. CONCLUSIONS: Botulium toxin type A injection is an effective way for treatment of patients with primary trigeminal neuralgia. Reference | Related Articles | Metrics

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Analysis of hub genes, pathways and immune checkpoints of CD8+ T cells in metastatic lymph nodes of head and neck squamous cell carcinoma in C3H/He mice ZHOU Di, HAN Nan-nan, LI Hua-sheng, YAN Ming, RUAN Min Shanghai Journal of Stomatology    2024, 33 (6): 586-593.   DOI: 10.19439/j.sjos.2024.06.004 Abstract （618）      PDF （2332KB）（1787）       Knowledge map    PURPOSE: To explore the expression of hub genes, pathways and inhibitory immune checkpoints of CD8+ T cells in metastatic lymph nodes of head and neck squamous cell carcinoma(HNSCC) in C3H/He mice. METHODS: A popliteal lymph node metastasis model of immunocompetent C3H/He mice was constructed with SCC-7 cell line of HNSCC, and the lymph node metastasis status was determined by immunofluorescence. CD8+ T cells in normal and metastatic lymph nodes were sorted by flow cytometry, and transcriptome sequencing analysis was performed to screen out differentially expressed genes. GO functional enrichment analysis and KEGG pathway enrichment analysis were performed sequentially. Flow cytometry and multiplex immunohistochemical were used to detect the expression of four immune checkpoints of CD8+ T cells in metastatic lymph nodes of tumor-bearing mice. SPSS 26.0 software package was used for statistical analysis. RESULTS: After 4 weeks of foot pad injection of SCC-7 cells, C3H/He mice displayed obvious metastasis in popliteal drainage lymph node. A total of 912 differentially expressed genes were screened out by transcriptome sequencing analysis of CD8+ T cells in normal and metastatic lymph nodes, including three inhibitory immune checkpoint-related genes which were upregulated(Pdcd1, Lag3 and Tigit). Eight tumor-related signaling pathways were screened out by KEGG network analysis, including Toll-like receptor signaling pathway, NF Kappa-B signaling pathway, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway, NOD-like receptor signaling pathway, PD-L1 and PD-1 immune checkpoint pathway in tumors and p53 signaling pathway. Flow cytometry showed high expression level of PD-1 and TIM-3 in CD8+ T cells in mouse metastatic lymph nodes. It was further confirmed by multiplex immunohistochemical that PD-1 was highly expressed in CD8+ T cells in metastatic lymph nodes of patients with HNSCC. CONCLUSIONS: Tumor-related signaling pathway of CD8+ T cells in mouse metastatic lymph nodes is significantly activated. The PD-1 expression level of CD8+ T in metastatic lymph nodes of mice and patients with HNSCC is markedly increased. Immunotherapy targeting CD8+ T cells may become a new strategy for the prevention and cure for lymph node metastasis of HNSCC. Reference | Related Articles | Metrics