上海口腔医学

上海口腔医学 ›› 2026, Vol. 35 ›› Issue (3): 271-275.doi: 10.19439/j.sjos.2026.03.008

• 论著 • 上一篇    下一篇

抗辐喷防治造血干细胞移植后口腔黏膜炎的效果观察

宋洁, 张茜倩, 倪靖   

  1. 首都医科大学宣武医院 血液科,北京 100053
  • 收稿日期:2025-07-17 修回日期:2025-08-12 发布日期:2026-07-02
  • 通讯作者: 宋洁,E-mail：15910554927@163.com
  • 作者简介:宋洁（1992—）,女,学士
  • 基金资助:
    北京市自然科学基金（7242072）

Therapeutic effect of anti-radiation spray on preventing and treating oral mucositis after hematopoietic stem cell transplantation

Song Jie, Zhang Qianqian, Ni Jing   

  1. Department of Hematology, Xuanwu Hospital, Capital Medical University. Beijing 100053, China
  • Received:2025-07-17 Revised:2025-08-12 Published:2026-07-02

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摘要： 目的: 探讨抗辐喷液体敷料防治造血干细胞移植（haematopoietic stem cell transplantation,HSCT）后口腔黏膜炎（oral mucositis,OM）的临床效果。方法: 选择2019年1月—2024年6月于首都医科大学宣武医院接受HSCT后发生OM的患者68 例,按干预方式分为对照组（n=40,标准口腔护理）与试验组（n=28,抗辐喷联合标准口腔护理）。比较两组OM发生时间、持续时间、不同分级OM 发生率及口干等相关症状发生率;记录干预前3天至移植后21天的疼痛数字评分（numerical rating scale,NRS）、血清炎症因子[C-反应蛋白（C-reactive protein,CRP）及降钙素原（procalcitonin,PCT）]水平及身体质量指数（body mass index,BMI）的变化。结果: 试验组Ⅱ~Ⅳ级OM发生率（35.7%）显著低于对照组（70.0%,P=0.046）;试验组OM发病时间显著晚于对照组,且持续时间显著短于对照组（P<0.001）。试验组口干发生率（7.2%）显著低于对照组（27.5%,P=0.036）,BMI 降低值显著小于对照组（P<0.001）。两组干预前3天NRS评分、CRP及 PCT水平无显著差异（P>0.05）;移植后两组上述指标均于7天达最高值。试验组移植后3、7、14、21天的NRS评分、CRP及PCT水平显著低于对照组（P<0.05）。两组均未出现不良反应。结论: 抗辐喷防治 HSCT后OM安全有效,能够改善患者生活质量,其作用机制可能与抑制炎症因子的表达有关。

关键词: 抗辐喷, 造血干细胞移植, 口腔黏膜炎, 炎症因子, 疼痛评分

Abstract: PURPOSE: To explore the clinical efficacy of radiation-resistant liquid wound dressing in preventing and treating oral mucositis (OM) after haematopoietic stem cell transplantation (HSCT). METHODS: A total of 68 patients who developed OM after HSCT at Xuanwu Hospital, Capital Medical University from January 2019 to June 2024 were selected and divided into the control group (n=40, standard oral care) and experimental group (n=28, Kangfu Pen combined with standard oral care) according to the type of intervention methods. The onset time and duration of OM, incidence of OM at different grades, and incidence of dry mouth and other related symptoms were compared between the two groups. Changes in the numerical rating scale (NRS) of pain, serum inflammatory factors [C-reactive protein (CRP) and procalcitonin (PCT)] levels, and body mass index (BMI) were recorded from 3 days before intervention to 21 days after transplantation. RESULTS: The incidence of grade Ⅱ-Ⅳ OM in the experimental group (35.7%) was significantly lower than that in the control group (70.0%, P=0.046); the onset time of OM in the experimental group was significantly later, and the duration was significantly shorter than those in the control group (P<0.001). The incidence of dry mouth in the experimental group (7.2%) was significantly lower than that in the control group (27.5%, P=0.036), and the decrease in BMI was significantly smaller than that in the control group (P<0.001). There were no significant differences in NRS scores, CRP, or PCT levels between the two groups 3 days before intervention (P>0.05); the above indicators in both groups reached the highest values on day 7 after transplantation. The NRS scores, CRP and PCT levels in the experimental group were significantly lower than those in the control group on days 3, 7, 14 and 21 after transplantation (P<0.05). No adverse reactions occurred in either group. CONCLUSIONS: Kangfu Pen is safe and effective in preventing and treating OM after HSCT, and can improve patients' quality of life. Its mechanism of action may be related to inhibiting the expression of inflammatory factors.

Key words: Anti-radiation spray, Hematopoietic stem cell transplantation, Oral mucositis, Inflammatory factors, Pain score

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