上海口腔医学

上海口腔医学 ›› 2020, Vol. 29 ›› Issue (2): 179-182.doi: 10.19439/j.sjos.2020.02.013

• 论著 • 上一篇    下一篇

重庆地区ABO血型与口腔颌面部恶性肿瘤关系的研究

王菲1, 邱丽华1,2, 庞谅1, 万书良1   

  1. 1.重庆医科大学附属口腔医院 口腔颌面外科,口腔疾病与生物医学重庆市重点实验室,重庆 401147;
    2.重庆市高校市级口腔生物医学工程重点实验室,重庆 401147
  • 收稿日期:2018-11-27 修回日期:2019-04-18 出版日期:2020-04-25 发布日期:2020-04-30
  • 通讯作者: 邱丽华,E-mail:gqyidi2001@163.com
  • 作者简介:王菲(1993-),女,硕士研究生,E-mail:2500446469@qq.com
  • 基金资助:
    重庆市社会民生科技创新专项项目(cstc2016shmszx00010);2016年重庆高校创新团队建设计划资助项目(CXTDG201602006);重庆市高校市级口腔生物医学工程重点实验室资助项目[渝教科(2014)55号]

Research on the relationship between ABO blood type and oral and maxillofacial malignancy in Chongqing area

WANG Fei1, QIU Li-hua1,2, PANG Liang1, WAN Shu-liang1   

  1. 1.Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Science. Chongqing 401147;
    2.Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education. Chongqing 401147, China
  • Received:2018-11-27 Revised:2019-04-18 Online:2020-04-25 Published:2020-04-30

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摘要： 目的 探讨重庆地区口腔颌面部恶性肿瘤的发生与ABO血型的关系。方法 以重庆医科大学附属口腔医院近5年确诊的重庆地区1054例口腔颌面部恶性肿瘤患者为研究对象,以同期健康体检人群为对照组,检测ABO血型。采用SPSS 22.0软件包中的χ2检验验证各组间的相关性,比较3种主要病种(鳞癌、腺样囊性癌、黏液表皮样癌)的OR值,判断各血型发生口腔颌面部恶性肿瘤的相对危险度。结果 口腔颌面部恶性肿瘤患者血型分布特点是O(34.2%)>A(32.8%)>B(24.6%)>AB(8.4%),与对照组血型构成比较无显著差异;O型血患者患黏液表皮样癌的相对危险性高于其他血型患者(P<0.05,OR=2.09,95%CI=1.04~4.17);男性患者中,黏液表皮样癌患者血型分布与对照组有显著差异(P<0.05),腺样囊性癌及黏液表皮样癌的O型血患者与其他血型患者构成有显著差异,为高风险人群(P<0.05, OR=3.06/3.06,95%CI=1.31~7.12)。结论 重庆地区口腔颌面部恶性肿瘤与ABO血型有关,O型血人群患黏液表皮样癌、男性中O型血人群患腺样囊性癌及黏液表皮样癌的风险性较高。

关键词: 口腔颌面部, 恶性肿瘤, ABO血型

Abstract: PURPOSE: To explore the relationship between ABO blood type and oral and maxillofacial malignancy in Chongqing area. METHODS: A total of 1054 patients with oral and maxillofacial malignant tumors diagnosed in the Stomatological Hospital of Chongqing Medical University in the past five years were selected as the research subjects, and the blood types of the healthy people were examined as the control group. SPSS 22.0 software package and Chi-square test were used to verify the correlation between the groups. The OR values of oral and maxillofacial malignancy of different blood types were compared among patients of three major cancers (squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma), so as to judge the relative risk of oral and maxillofacial malignant tumors of each blood type. RESULTS: The distribution of blood type in oral and maxillofacial malignancy patients was as follows: O(4.2%)>A(32.8%)>B(24.6%)>AB(8.4%), there was no significant difference in blood types between the patients and the controls. Patients with blood type O were easier to develop mucoepidermoid carcinoma compared with patients with other blood types (P<0.05, OR=2.09, 95%CI=1.04~4.17). In addition, the distribution of blood type of patients with mucoepidermoid carcinoma was significantly different from the control group. Males with blood type O were different from males with other blood types, which were more susceptible to adenoid cystic carcinoma and mucoepidermoid carcinoma (P<0.05, OR=3.06/3.06, 95%CI=1.31~7.12). CONCLUSIONS: There is certain relationship between the occurrence of oral and maxillofacial malignancy and ABO blood type in Chongqing area. The population of O blood type is easier to develop mucoepidermoid carcinoma while males with O blood type are more likely to develop adenoid cystic carcinoma and mucoepidermoid carcinoma.

Key words: Oral and maxillofacial, Malignant tumor, ABO blood type

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