上海口腔医学

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (6): 654-657.doi: 10.19439/j.sjos.2017.06.018

• 论著 • 上一篇    下一篇

rhEGF对口腔颌面部外伤患者血清EGF及炎症因子水平的影响

印志法, 王思明   

  1. 连云港市第二人民医院 口腔科,江苏 连云港 222023
  • 收稿日期:2017-07-05 修回日期:2017-10-10 出版日期:2017-12-20 发布日期:2018-01-09
  • 通讯作者: 印志法,E-mail:619806006@qq.com
  • 作者简介:印志法（1978-）,男,学士,副主任医师

Effect of rhEGF on the levels of serum EGF and inflammatory cytokines in patients with oral and maxillofacial trauma

YIN Zhi-fa, WANG Si-ming   

  1. Department of Stomatology, The Second People's Hospital of Lianyungang City. Lianyungang 222023,Jiangsu Province, China
  • Received:2017-07-05 Revised:2017-10-10 Online:2017-12-20 Published:2018-01-09

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摘要： 目的: ：探讨口腔颌面部外伤患者采用美容清创缝合联合重组人表皮生长因子（recombinant human epidermal growth factor,rhEGF）治疗对创面愈合、瘢痕形成、血清表皮生长因子及炎症因子的影响。方法: 选取我院2015年1月—2016年12月收治的82例口腔颌面部外伤患者,所有患者均接受美容清创缝合术等基础治疗,其中41例患者加用rhEGF治疗（研究组）,41例仅采取美容清创缝合术等基础治疗（对照组）。评价2组患者瘢痕情况,观察并记录2组患者切口愈合时间,比较2组患者术前、术后2 d及5 d的血清表皮生长因子、白细胞介素 6(interleukin-6,IL-6)、肿瘤坏死因子 ɑ(tumor necrosis factor alpha, TNF-α) 和白细胞介素1(interleukin-1,IL-1)水平。采用SPSS16.0软件包对数据进行统计学处理。结果: 研究组患者平均切口愈合时间为（5.1±1.3）d,对照组为（7.4±1.9）d,2组相比差异显著（t=6.397,P<0.01）。研究组显效27例（65.85%）、有效13例（31.71%）、无效1例（2.44%）,对照组显效19例（46.34%）、有效17例（41.46%）和无效5例（12.20%）,2组相比差异显著（P<0.05）。术前2组患者的血清表皮生长因子、IL-6、TNF-α和IL-1差异无显著性（P>0.05）;术后2 d和5 d,研究组血清表皮生长因子水平显著高于对照组（P<0.05）,研究组患者血清IL-6、TNF-α和IL-1水平显著低于对照组（P<0.05）。2组患者术后并发症发生率具有显著性（P<0.05）。结论: 口腔颌面部外伤患者采用美容清创缝合联合rhEGF治疗能促进创面愈合、降低炎症反应程度。

关键词: 口腔颌面部, 美容清创缝合术, 重组人表皮生长因子, 炎性因子

Abstract: PURPOSE: To investigate the effect of debridement combined with recombinant human epidermal growth factor (rhEGF) on wound healing, scar formation, serum epidermal growth factor and inflammatory factors in patients with oral and maxillofacial trauma. METHODS: Eight-two cases with oral and maxillofacial trauma treated in our hospital (January 2015 to December 2016) were retrospectively analyzed. All patients received routine treatment, 41 received rhEGF besides routine treatment (experimental group), 41 patients received only cosmetic debridement and suturing (control group). The effect, wound healing time of 2 groups were recorded and compared. The serum epidermal growth factor, interleukin -6 (IL-6), tumor necrosis factor alpha (TNF-α) and interleukin -1 (Interleukin-1, IL-1) before and after operation were compared between 2 groups. SPSS16.0 software package was used to analyze the data. RESULTS: The average wound healing time of the patients in the experimental group was 5.1±1.3 days, and the average wound healing time of patients in the control group was 7.4±1.9 days, the difference between 2 groups was statistically significant (t=6.397, P<0.01). The effective rate of the experimental group was significantly higher than the control group (P<0.05). Before operation, the serum epidermal growth factor, IL-6, TNF-α and IL-1 in 2 groups had no significant differences (P>0.05); 2 days and 5 days after operation, the serum epidermal growth factor level of the experimental group was significantly higher than the control group(P<0.05). The serum IL-6, TNF-α , IL-1 level of the experimental group were significantly lower than the control group(P<0.05).The side effects happened in the experimental group were significantly lower than control group (P<0.05). CONCLUSIONS: Patients with oral and maxillofacial trauma treated by debridement combined with rhEGF can promote wound healing and reduce the degree of inflammation.

Key words: Oral and maxillofacial region, Debridement, Recombinant human epidermal growth factor, Inflammatory factor

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