Top Read Articles

Published in last 1 year |

In last 2 years |

In last 3 years |

All

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Application of 4R crisis management theory in the protection of oral mucositis in patients with autologous hematopoietic stem cell transplantation ZOU Qian, CHEN Mei-hua Shanghai Journal of Stomatology    2024, 33 (6): 676-680.   DOI: 10.19439/j.sjos.2024.06.019 Abstract （1020）      PDF （688KB）（267）       Knowledge map    PURPOSE: To investigate the clinical value of nursing care plans employing 4R crisis management model for prevention of oral mucositis in patients with autologous hematopoietic stem cell transplantation. METHODS: According to different intervention time points, totally 40 transplantation patients from May 2019 to December 2020 were selected as the control group, while 68 transplantation patients from January 2021 to January 2023 were selected as the experimental group. Compared to the control group, patients in the experimental group adopted more comprehensive risk management measures and applied 4R crisis theory. The preventive and therapeutic outcomes were compared in the aspects of oral mucosal inflammation incidence, grade, time to resume orally fed diet and inpatient stay of two groups of patient. SPSS 27.0 software package was used for statistical analysis. RESULTS: Oral mucositis occurred in 76.5% of patients in the experimental group, which was significantly lower than the control group (100%) (P<0.05). Severe oral mucositis (grades Ⅲ and Ⅳ) were 11.8% in the experimental group, which was significantly lower than the control group(65.0%). The clinical nursing satisfaction of the experimental group was significantly higher than that of the control group(P<0.001). There was no significant difference in hospital duration or oral refeeding time between the two groups(P>0.05). CONCLUSIONS: The application of 4R crisis management strategy can substantially decrease oral mucositis occurrences and severity, thereby enhancing the effectiveness of oral care management for autologous hematopoietic stem cell transplantation patients, reducing patient discomfort, accelerating recovery time and improving quality of life . The strategy has promising clinical potential of application. Reference | Related Articles | Metrics

Select

Shanghai Journal of Stomatology    2025, 34 (4): 0-0.   Abstract （970）      PDF （722KB）（51）       Knowledge map    Related Articles | Metrics

Select

Accuracy of tooth segmentation algorithm based on deep learning ZHANG Bo-jun, CUI Zhi-ming, LIU Zhi-xu, CHEN Si-yue, GU Kai-jun, LI Si-tong, WU Yan-qi, SHEN Ding-gang, ZHU Min Shanghai Journal of Stomatology    2024, 33 (4): 339-344.   DOI: 10.19439/j.sjos.2024.04.002 Abstract （901）      PDF （933KB）（416）       Knowledge map    PURPOSE: The established automatic AI tooth segmentation algorithm was used to achieve rapid and automatic tooth segmentation from CBCT images. The three-dimensional data obtained by oral scanning of real isolated teeth were used as the gold standard to verify the accuracy of the algorithm. METHODS: Thirty sets of CBCT data and corresponding 59 isolated teeth were collected from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. The three-dimensional tooth data in CBCT images were segmented by the algorithm. The digital information obtained by scanning the extracted teeth after processing was used as the gold standard. In order to compare the difference between the segmentation results and the scanning results of the algorithm. The Dice coefficient(Dice), sensitivity (Sen) and average symmetric surface distance (ASSD) were selected to evaluate the segmentation accuracy of the algorithm. The intra-class correlation coefficient(ICC) was used to evaluate the differences in length, area, and volume between the single tooth obtained by the AI system and the digital isolated tooth. Due to the existence of CBCT with different resolution, ANOVA was used to analyze the differences between groups with different resolution, and SNK method was used to compare them between two groups. SPSS 25.0 software package was used to analyze the data. RESULTS: After comparing the segmentation results with the in vitro dental scanning results, the average Dice value was (94.7±1.88)%, the average Sen was (95.8±2.02)%, and the average ASSD was (0.49±0.12) mm. By comparing the length, area and volume of a single tooth obtained by the digital isolated tooth and the AI system, the ICC values of the intra-group correlation coefficients were 0.734, 0.719 and 0.885, respectively. The single tooth divided by the AI system has a good consistency with the digital model in evaluating the length, area and volume, but the segmentation results were still different from the real situation in terms of specific values. The smaller the voxel of CBCT, the higher the resolution, the better the segmentation results. CONCLUSIONS: The CBCT tooth segmentation algorithm established in this study can accurately achieve the tooth segmentation of the whole dentition in CBCT at all resolutions. The improvement of CBCT resolution ratio can make the algorithm more accurate. Compared with the current segmentation algorithms, our algorithm has better performance. Compared with the real situation, there are still some differences, and the algorithm needs to be further improved and verified. Reference | Related Articles | Metrics

Select

TNF-α regulated SHED osteogenic differentiation through ERK1/2-Runx2 signaling pathway WANG Jing, XU Na, REN Hui-di Shanghai Journal of Stomatology    2024, 33 (2): 135-140.   DOI: 10.19439/j.sjos.2024.02.005 Abstract （791）      PDF （1435KB）（206）       Knowledge map    PURPOSE: To investigate the effect of TNF-α on osteogenic differentiation of stem cells from human exfoliated deciduous teeth (SHED), and to analyze the changes of ERK1/2-Runx2 signaling pathway in the regulation process. METHODS: SHED cells were isolated and cultured from normal deciduous permanent teeth of healthy children aged 6-8 years old, and the third passage of SHED cells were taken and divided into control group (osteogenic inducer culture), observation group (osteogenic inducer and TNF-α co-culture) and agonist group (osteogenic inducer, TNF-α and ERK pathway agonist co-culture). The osteogenic differentiation was determined by alizarin red staining. The protein expression levels of Osterix, OPN, ERK1/2, pERK1/2 and Runx2 in SHED cells were determined by Western blot. The expressions of Osterix, OPN, ERK1/2, pERK1/2 and Runx2 mRNA were detected by qRT-PCR. Statistical analysis was performed with SPSS 26.0 software package. RESULTS: Comparison of osteogenic differentiation ability of the three groups of cells showed that red-brown mineralized nodules were observed in the three groups of cells. Compared among the three groups, the control group had the most mineralized nodules, followed by the activation group, and the observation group had the least mineralized nodules. Compared with the control group, the expression levels of Osterix and OPN protein and mRNA in the observation group and the agonist group were significantly decreased, while the expression levels of Osterix and OPN protein and mRNA in the agonist group were significantly higher than those in the observation group. There was no significant difference in the expression levels of ERK1/2 protein and mRNA among the three groups, while the expression levels of pERK1/2 and Runx2 protein and mRNA in the observation group and the agonist group were significantly higher than those in the control group, and the expression levels of pERK1/2 and Runx2 protein and mRNA in the agonist group were significantly higher than those in the observation group. CONCLUSIONS: TNF-α can inhibit osteogenic differentiation of SHED cells, which may be related to the inhibition of ERK1/2-Runx2 signaling pathway. Reference | Related Articles | Metrics

Select

Differential miRNA profiling and target gene analysis of marrow mesenchymal stem cells in postmenopausal osteoporotic mouse mandibles YANG Shan-shan, ZHANG Wei, HU Xiao-hua, YANG Xiao-hong Shanghai Journal of Stomatology    2024, 33 (6): 561-571.   DOI: 10.19439/j.sjos.2024.06.001 Abstract （768）      PDF （2245KB）（431）       Knowledge map    PURPOSE: To explore the differential miRNA expression profiles and predicted target genes of mandibular bone marrow mesenchymal stem cells (MBMSCs) in a postmenopausal osteoporosis (POP) mouse model using bioinformatics methods, providing new targets for diagnosis, treatment, and prevention of POP. METHODS: POP mouse model was established by performing ovariectomy surgery, and MBMSCs were obtained using whole bone marrow adherent culture method. Microarray sequencing was performed to detect the miRNA expression profile of MBMSCs. Subsequently, miRNA identification and prediction analysis were conducted, along with the prediction of target genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and protein-protein interaction (PPI) network analysis were performed on the predicted target genes. Key hub genes were identified using algorithms such as Degree, Betweenness, and Closeness. The data were analyzed by GraphPad Prism 8.0 and R language. RESULTS: A total of 84 differentially expressed miRNAs were obtained using a threshold of P<0.05, with 33 upregulated and 51 downregulated miRNAs. GO and KEGG enrichment analyses of the 84 differentially expressed miRNAs revealed their involvement in various biological processes and pathways. Among them, 130 target gene mRNAs were enriched in the "regulation of stem cell pluripotency" signaling pathway. PPI network analysis and hub gene selection were performed for the 130 predicted target gene mRNAs, resulting in the identification of 7 reliable hub genes: Ctnnβ1, Hras, Kras, Akt1, Mapk3, Smad3, and Smad2. Among these hub genes, Ctnnβ1, Akt1, Mapk3, Smad3, and Smad2 were found to be significantly associated with POP. CONCLUSIONS: The differentially expressed miRNAs identified in MBMSCs of POP mice may serve as potential biomarkers and play important roles in the pathogenesis of POP. This study provides new research direction and theoretical basis for the diagnosis and treatment of POP. Reference | Related Articles | Metrics

Select

An in vitro experiment on the stability and irritant of hypochlorous acid in oral cavity LIU Zhao-chen, SUN Pei, PAN Ke-qing, WANG Pei-yan, ZHANG Hui, YUAN Chang-qing, DENG Jing Shanghai Journal of Stomatology    2024, 33 (2): 141-147.   DOI: 10.19439/j.sjos.2024.02.006 Abstract （706）      PDF （2020KB）（388）       Knowledge map    PURPOSE: To study the stability of physicochemical properties and sterilizing effect about two commercially available hypochlorous acid (HClO) products under simulated clinical conditions, and to evaluate the compatibility of HClO on soft and hard tissues and cells in oral cavity. METHODS: Samples of HClO solution with different production processes were prepared, to detect the changes of physicochemical indexes of each sample over time under simulated clinical conditions (shielded from light at 20-25 ℃, open the cover for 5 minutes every day), including free available chlorine, oxidation-reduction potential and pH. Through suspension quantitative germicidal test, the antibiosis-concentration curve of HClO solution was made, so as to calibrate the change of antibacterial ability of disinfectant with the decrease of available chlorine content during storage. Pulp, tongue and dentine were immersed in PBS, 100 ppm HClO, 200 ppm HClO and 3% NaClO. The influence on soft and hard tissues was evaluated by weighing method and microhardness test. The toxic effects of HClO, NaClO and their 10-fold diluent on human gingival fibroblasts were determined by CCK-8 cytotoxicity assay. GraphPad PRIS 8.0 software was used to analyze the data. RESULTS: Under simulated conditions, the free available chlorine (FAC) of HClO solution decayed with time, and the attenuation degree was less than 20 ppm within 1 month. The bactericidal effect of each HClO sample was still higher than 5log after concentration decay. There was no obvious dissolution and destruction to soft and hard tissues for HClO(P>0.05). The cell viability of HClO to human gingival fibroblast cells (HGFC) was greater than 80%, which was much higher than 3% NaClO (P<0.001). CONCLUSIONS: The bactericidal effect and stability of HClO solution can meet clinical needs, which has low cytotoxicity and good histocompatibility. It is expected to become a safe and efficient disinfection product in the field of living pulp preservation and dental pulp regeneration. Reference | Related Articles | Metrics

Select

The effect of Frankel Ⅲ orthodontic appliance combined with lip muscle training in the treatment of malocclusion during mixed dentition DING Min-lin, ZHANG Hai-liang, ZHANG Ji-min Shanghai Journal of Stomatology    2024, 33 (4): 432-437.   DOI: 10.19439/j.sjos.2024.04.018 Abstract （700）      PDF （648KB）（369）       Knowledge map    PURPOSE: To exploring the clinical effect of lip muscle training combined with Frankel Ⅲ orthodontic appliances in correcting Class Ⅲ malocclusion during the mixed dentition period. METHODS: One hundred children with Class Ⅲ malocclusion during the mixed dentition period admitted to Hangzhou Greentown Stomatological Hospital from June 2018 to December 2022 were selected. The children were randomly divided into a combination group (treated with lip muscle training and Frankel Ⅲ orthodontic appliance) and a control group (treated with Frankel Ⅲ orthodontic appliance), with 50 cases in each group. X-ray cephalometric indicators, temporomandibular joint parameters, upper airway measurement parameters and 12 month follow-up of the two groups of children were compared before and after treatment. SPSS 21.0 software package was used for statistical analysis. RESULTS: Before treatment, there was no significant difference of SNA, SNB, ANB, U1-NA, L1-NB, ANS-Ptm, S-Ptm, Co Po, Co-S, MP-SN, MP-FH and NP-FH between the combination group and the control group (P>0.05). After treatment, ANB, U1-NA, L1-NB and MP-SN in the combination group were significantly higher than those in the control group, while NP-FH were significantly lower than that in the control group(P<0.05). Before treatment, there was no significant difference of the joint space, anterior joint space and posterior joint space between the combination group and the control group patients(P>0.05); after treatment, the joint space and the joint space in the combination group were significantly higher than those in the control group(P<0.05). Before treatment, there was no significant difference of Ba PNS, Ad1 PNS, Ad2 PNS, Mc1 Mc2, SPP-SPPW, U-MPW, PAS and V-LPW between the combination group and the control group(P>0.05); after treatment, Ad2-PNS in the combination group was significantly higher than that in the control group(P<0.05). After 12 months of follow-up, the recurrence rate of the combination group was 2.00%, which was significantly lower than that (16.00%) of the control group (P<0.05). CONCLUSIONS: The combination of lip muscle training and Frankel III orthodontic appliances is more conducive to correcting Class III malocclusion during the replacement period, improving upper airway morphology, and reducing the recurrence rate after treatment. Reference | Related Articles | Metrics

Select

Comparison of the effects of using iRoot BP plus and MTA apical barrier surgery in young permanent teeth with chronic apical periodontitis SUN Yan-ni, ZHAO Lei, LIU Wei, YIN Xiao-ping Shanghai Journal of Stomatology    2024, 33 (3): 260-264.   DOI: 10.19439/j.sjos.2024.03.008 Abstract （634）      PDF （598KB）（345）       Knowledge map    PURPOSE: To explore the effect of using iRoot BP plus and MTA apical barrier surgery in young permanent teeth with chronic apical periodontitis. METHODS: A total of 122 patients with chronic periapical periodontitis with open root tips of permanent teeth were randomly divided into experimental group (n=61, 61 teeth) and a control group (n=61, 61 teeth). Patients in the experimental group received iRoot BP plus plus apical barrier surgery, while those in the control group received MTA apical barrier surgery. The old periapical index (O-PAI), apical transmission area, efficacy, treatment times, and inflammatory factor levels of the two groups of patients were compared at 3, 6, 9, and 12 months after surgery. SPSS 19.0 software package was used for statistical analysis. RESULTS: At 12 months after surgery, the O-PAI ratings of the experimental group and the control group were (1.48±0.36) and (1.71±0.42), respectively, and the apical transmission area was (0.51± 0.14) and (1.09±0.31). There was a significant difference in the O-PAI ratings and apical transmission area between the two groups(P<0.05). At 3 months, 6 months, and 12 months after surgery, the O-PAI scores of patients in both groups gradually decreased (P<0.05). After 12 months of treatment, the success rates of the experimental group and the control group were 98.36% and 88.52%, respectively, with significant difference between the two groups (P<0.05). The treatment frequency of patients in the experimental group and the control group was (3.64±0.58) times and (4.72±0.61) times, respectively, with a significant difference between the two groups(P<0.05). After 3 months of treatment, the serum hs-CRP levels in the experimental group and the control group were (6.89±1.13) mg/L and (7.25±1.40) mg/L, respectively, with a significant difference compared to pre-treatment(P<0.05). After 3 months of treatment, the serum IL-6 levels in the experimental group and the control group were (82.04±19.62) mg/L and (87.52±20.85) mg/L, respectively, with significant differences compared to pre-treatment (P<0.05). There was no significant difference in serum IL-6 and hs-CRP levels between the two groups before and after treatment(P>0.05). CONCLUSIONS: iRoot BP plus apical barrier surgery for the treatment of chronic apical periodontitis with open permanent teeth can reduce the O-PAI index, decrease the number of postoperative visits, and have a higher postoperative success rate. Reference | Related Articles | Metrics

Select

Comparative study of iRoot SP and AH Plus on root canal sealing ability in periodontally compromised teeth LU Min, LIU Shuang, WANG Ya-nan, SONG Ai-mei Shanghai Journal of Stomatology    2024, 33 (5): 455-460.   DOI: 10.19439/j.sjos.2024.05.002 Abstract （599）      PDF （1119KB）（288）       Knowledge map    PURPOSE: This study was aimed to compare the difference between iRoot SP and AH Plus on root canal sealing ability for teeth extracted due to severe periodontitis and explore whether the dentin tubule pathway plays an important role in the development of endodontic-periodontic lesions(EPL), in order to provide a theoretical basis for selection of proper time for root canal therapy and suitable root canal sealants in patients with EPL. METHODS: Fifty single-root anterior teeth extracted due to severe periodontitis were selected. The roots were completely debrided to remove the calculus, dental plaque and cementum. They were divided into two groups, namely group A and group B, with 25 teeth in each group which included 21 experimental teeth and 4 negative control teeth. The root canals were filled with iRoot SP (group A) and AH Plus(group B) plus gutta-percha by cold lateral condensation technique. All roots were cut across the middle section and divided into coronal segment (group A1 and B1) of which the coronal section and apical section were sealed with self-etching adhesive and fluid resin, and then covered with melted casting wax twice. The apical segment of the experimental group was further divided into two subgroups, namely, the unsealed apical foramen group(group A2 and group B2) and sealed apical foramen group (group A3 and group B3). In group A2 and group B2, only the coronal section was sealed as mentioned above. While in group A3 and B3, both the coronal sections and apical foramen were sealed. The whole surface of the specimens in negative control group were all covered with melted casting wax twice. The samples were immersed in 1% methylene blue dye solution for 14 d, then they were longitudinally cut in half. Vernier caliper was used to measure the penetration length of the dye solution along the inner wall of each root canal. The sample sections were all photographed to process for Image Pro Plus software analysis of the penetration area of the dye solution in dentin tubule. The intra-group and inter-group differences were analyzed by one-way analysis of variance and LSD method, respectively. The data were analyzed by SPSS 26.0 software package. RESULTS: The penetration length of group A2 was significantly longer than that of group A3 (P<0.05). The penetration length of group B2 was significantly longer than that of group B1 and B3 (P<0.05). There was no significant difference between the corresponding subgroups of group A and group B (P>0.05). Statistical analysis showed that the percentage of stained dentin tubule area in group A1 was significantly lower than that in group A2(P<0.05), and the area percentage in group B1 was significantly lower than that in group B2 and B3(P<0.05). There was no significant difference between the corresponding subgroups of group A and group B(P>0.05). CONCLUSIONS: For periodontally compromised teeth, neither iRoot SP nor AH Plus paste combined with gutta-percha by cold lateral condensation technique could completely seal the root canal. There is no significant difference between iRoot SP and AH Plus paste on root canal sealing ability in teeth from periodontitis patients. Dentin tubules are not the main pathway of periodontal tissue and pulp communication. The pathway in the apical 1/2 segment of the root plays a more important role in the occurence of EPL, which suggest that root canal therapy may be taken into consideration when the clinical attachment loss reaches more than the apical 1/2 of the root. Reference | Related Articles | Metrics

Select

Three-dimensional finite element analysis of different attachment designs for lateral incisors during inward retraction of upper anterior teeth in clear aligner CHEN Jing-cheng, ZHAO Meng-li, CHENG Zhi-heng, LIU Xin Shanghai Journal of Stomatology    2024, 33 (4): 360-366.   DOI: 10.19439/j.sjos.2024.04.005 Abstract （595）      PDF （3163KB）（302）       Knowledge map    PURPOSE: To investigate the biomechanical expression of different shapes of attachments on the maxillary anterior teeth during the lingual tooth movement process using clear aligners, providing new insights for orthodontists to improve the clinical design. METHODS: In this study, CBCT data were simulated using the three-dimensional finite element technique. Attachments of various shapes, including no attachment(A1), rectangular attachment(A2), wedge-shaped attachment(A3), and curved arc attachment(A4), were designed on the lateral incisors. Ansys software was employed to calculate the three-dimensional changes in the lateral incisors, dental arch, and clear aligners and the distribution of equivalent stress on the periodontal ligament(von Mises) under the same load conditions. RESULTS: The coronal displacement of the lateral incisors showed the following variations: A1>A4>A3>A2. The sagittal displacement exhibited the following variations: A3>A4>A1>A2. The vertical elongation demonstrated the following variations: A4>A3> A1>A2. The overall displacement of each dental arch displayed an arch-shaped trend. Different regions of the clear aligners exhibited variations in deformation. The von Mises distribution of the periodontal ligament in A1 and A2 group showed similarities, while A3 group exhibited stress concentration only in the lingual area of the root's one-third region. Group A4 experienced significantly higher stress in the cervical region compared to A1 and A2 group. CONCLUSIONS: Rectangular attachments and curved arc attachments possess advantages in coronal control, with rectangular attachments exhibiting the best control effect in vertical control. The area of attachment force and actual displacement efficiency do not have an absolute correlation, as the shape of the force-bearing surface can significantly affect its specific biomechanical expression. Reference | Related Articles | Metrics

Select

Analysis of saliva and intestinal microbial community in children with severe caries based on 16S rDNA high-throughput sequencing technology LI Yang, ZHAO Meng-jun, LU Hong-qiao, LIU Jian-guo, LIU Yun-kun, WU Jia-yuan Shanghai Journal of Stomatology    2024, 33 (2): 164-169.   DOI: 10.19439/j.sjos.2024.02.010 Abstract （566）      PDF （1054KB）（341）       Knowledge map    PURPOSE: The characteristics of saliva and intestinal microbial community in children with high caries and no caries were analyzed by 16S rDNA high-throughput sequencing. METHODS: Among 431 children aged 3-5 years old in Zunyi City who were investigated previously by our team, 25 children in the high caries group and the same in the caries-free group were selected for fecal and saliva samples. 16S rDNA high-throughput sequencing was used to analyze the bacterial flora structure of the samples and identify the species with different relative abundance at the species level. SPSS 18.0 software package was used for data analysis. RESULTS: The diversity of intestinal flora in the high caries group was higher than that in the caries-free group, and the difference was statistically significant(P<0.05). The diversity of salivary flora in the high caries group was more than that in the caries-free group, with no significant difference(P>0.05). At phylum level,there was no significant difference in intestinal and salivary flora between children with high caries and children without caries. At gene level, Blautia, [Eubacterium] hallii group and [Eubacterium] eligens group in the intestine of caries-free group were significantly higher than those of high caries group(P<0.05), while Parasutterella and Christensenellaceae R-7 group were significantly lower than those of high caries group(P<0.05). At gene level, Peptostreptococcus in saliva of caries-free group was significantly higher than that in high caries group(P<0.05). Dialister, Kingella, Escherichia-Shigella and Treponema in saliva of caries-free group were significantly lower than those in high caries group(P<0.05). CONCLUSIONS: There are significant differences in species composition of intestinal flora but no in salivary flora between children with high caries and children without caries. Reference | Related Articles | Metrics

Select

Clinical study on guiding parents to promote oral health of pre-school children through self-made oral science video ZHANG Shi-yun, ZHU Jia-lin, ZHOU Yi-lei, LU Wei-fang, SU Hong-ru Shanghai Journal of Stomatology    2024, 33 (5): 500-505.   DOI: 10.19439/j.sjos.2024.05.010 Abstract （561）      PDF （750KB）（321）       Knowledge map    PURPOSE: To evaluate the clinical effect of self-made oral science video on guiding parents to promote oral health of pre-school children, and to explore a more effective new technology in oral hygiene education. METHODS: One hundred and four 3-6 years old children with early childhood caries from Shanghai Xuhui District Dental Center were randomly recruited and divided into intervention group(n=52) and control group (n=52) during July to September 2022. At recruitment and 1 month after recruitment, the control group received routine oral health education, while the intervention group parents watched self-made oral health video and received routine oral health education. Plaque index (PLI), decayed missing filled tooth surface (dmfs) as well as oral health knowledge, attitude, practice(KAP) score of parents were compared between the two groups 1 and 6 months after recruitment.SPSS 26.0 software package was used for statistical analysis of the data. RESULTS: At 1 and 6 months after recruitment, the KAP score of intervention group （86.445±7.156, 85.694±5.880）was significantly higher than that of the control group [82.571(77.286, 88.142),81.853±7.482]（P<0.05）. The PLI of intervention group [2.014±0.403, 1.895(1.250, 2.100)] was significantly lower than that of the control group（P<0.05）. There was no significant difference of dmfs between the intervention group and control group(P>0.05). CONCLUSIONS: As a new oral hygiene education technology, self-made oral science video is effective on improving oral health condition of pre-school children and the KAP condition of their parents. Reference | Related Articles | Metrics

Select

Prevalence of temporomandibular joint disc displacement in patients malocclusion ZHOU Guo-li, YUAN Ling-jun, LI Hai-rui, SHI Wen-tao, FANG Bing Shanghai Journal of Stomatology    2024, 33 (6): 656-660.   DOI: 10.19439/j.sjos.2024.06.016 Abstract （528）      PDF （553KB）（228）       Knowledge map    PURPOSE: To investigate the prevalence characteristics of temporomandibular joint disc displacement in patients with malocclusion and influencing factors of disc displacement, and to provide reference for orthodontic treatment. METHODS: A total of 1 157 consecutive orthodontic cases admitted to the Department of Orthodontics at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2012 to December 2021 were selected retrospectively. Based on temporomandibular joint MRI, the prevalence of disc displacement in orthodontic cases was investigated. The influencical factors of gender, age and skeletal classification on disc displacement was analyzed. SPSS 25.0 software package was used for data analysis. RESULTS: Among 1 157 orthodontic cases, there were 672 cases(58.08%) of disc displacement, and 334 cases(28.87%) had anterior disc displacement. The prevalence of disc displacement in female was significantly higher than that in male. The prevalence of disc displacement in skeletal Class Ⅱ malocclusion was significantly higher than that in skeletal Class Ⅲ malocclusion. In orthodontic cases aged between 10 and 18, the prevalence of disc displacement increased with age. CONCLUSIONS: There is a high proportion of abnormal articular disc position in patients with malocclusion. Age, gender(female) and skeletal Class Ⅱ malocclusion have higher correlation with temporomandibular joint disc displacement. Reference | Related Articles | Metrics

Select

Comparison of the effect of resin restoration and CAD/CAM all-porcelain veneer restoration on anterior tooth space ZHANG Guo-qing, WANG Wei-guo Shanghai Journal of Stomatology    2024, 33 (6): 647-650.   DOI: 10.19439/j.sjos.2024.06.014 Abstract （522）      PDF （484KB）（202）       Knowledge map    PURPOSE: To compare the aesthetic effects of resin restoration and CAD/CAM all-porcelain veneer restoration on anterior tooth space. METHODS: The medical records of 185 patients (333 teeth) with anterior space restoration from February 2023 to January 2024 were retrospectively analyzed. The patients were divided into control group(n=92, 170 teeth) and experimental group(n=93, 163 teeth) according the restoration methods. The control group was repaired with resin,while the experimental group was repaired with CAD/CAM all-porcelain veneer. The clinical effect, masticatory function, periodontal health status, aesthetic effect and complications were compared between the two groups. SPSS 25.0 software package was used for statistical analysis of the data. RESULTS: The total effective rate of the experimental group was significantly higher than that of the control group (P<0.05). After 1 month of treatment, the masticatory function scores of 2 groups were significantly increased (P<0.05), and the experimental group was higher than the control group (P<0.05). The gingival index (GI) score and plaque index (PI) score of the experimental group were significantly lower than those of the control group (P<0.05), but there was no significant difference in probing depth (PD) between the two groups (P>0.05). The abutment sensitivity and pulp status, the color matching degree with neighboring teeth, the edge color of prosthesis and the grade distribution of prosthesis integrity in the experimental group were significantly better than these of the control group (P<0.05). There was no significant difference in the total incidence of complications between the two groups (P>0.05). CONCLUSIONS: Compared with resin repair, CAD/CAM porcelain veneer has better effect on anterior tooth space repair, which can improve patients' chewing function and periodontal health, enhance aesthetic effect, and reduce the risk of complications. Reference | Related Articles | Metrics

Select

Construction and validation of an immune prognostic risk model in oral squamous cell carcinoma ZHAO Jiao, SUI Bai-yan, LIU Xin, RUAN Min Shanghai Journal of Stomatology    2024, 33 (4): 345-353.   DOI: 10.19439/j.sjos.2024.04.003 Abstract （521）      PDF （3120KB）（295）       Knowledge map    PURPOSE: To analyze the immune-related core genes differentially expressed in oral squamous cell carcinoma(OSCC) and construct an immune-related prognostic risk model for OSCC patients. METHODS: Weighted gene co-expression network analysis of RNA sequencing data from OSCC patients in the Cancer Genome Atlas (TCGA) database was conducted to identify immune-related modules and core genes. Core genes associated with immune prognosis were screened using univariate Cox regression analysis and survival analysis to construct an immune-related prognostic risk model for OSCC. The prognostic risk model's predictive ability was evaluated using Kaplan-Meier analysis, receiver operating characteristic curves, and external datasets from GSE41613. The expression of 8 immune prognostic core genes in tumor samples from OSCC patients was detected by real-time quantitative PCR assay(RT-qPCR), and the correlation between risk score and depth of invasion was assessed by calculating risk scores for OSCC patients. Statistical analysis was performed with SPSS 21.0 software package. RESULTS: Prognostic risk model for OSCC was successfully constructed based on 8 immune prognostic core genes(CSF2RA, CLEC4C, COL5A3, CTSG, EDNRA, GPC4, GUCY1A2, ANGPT2). The prognostic risk model demonstrated perfect predictive value validated using Kaplan-Meier analysis, receiver operating characteristic curve, and the GSE41613 dataset. The risk scores of OSCC patients calculated based on this model were positively correlated with the depth of invasion, indicating that the model have the ability to predict the potential risk of OSCC. CONCLUSIONS: An OSCC prognostic risk model is constructed based on the signatures of 8 immune prognostic core genes, which may effectively predict the prognosis of OSCC patients, providing an important reference for immune prevention of OSCC. Reference | Related Articles | Metrics

Select

Study of the effect of different methods on the removal of calcium hydroxide in root canal by micro-computed tomography in vivo WU Tian-tian, Han Yan-yan, WANG Yi Shanghai Journal of Stomatology    2024, 33 (3): 225-228.   DOI: 10.19439/j.sjos.2024.03.001 Abstract （513）      PDF （679KB）（293）       Knowledge map    PURPOSE: To establish molar root canal model with micro-computed tomography (Micro-CT) and evaluate the removal efficiency of calcium hydroxide by different methods. METHODS: Eight molar teeth (24 root canals) extracted from the Department of General Dentistry, Shanghai Ninth People's Hospital from October 2023 to February 2024 were collected. Root canal preparation was instrumented by M3 according to standard root canal treatment procedures, then calcium hydroxide was injected into the root canal. One week later, the samples were randomly divided into 3 groups according to different irrigation methods(n=8): lateral opening syringe group, ultrasonic group and sonic vibration group. Micro-CT was used to reconstruct the root canal system before and after irrigation, and independent root canals were marked with different colors. The root canals were divided into upper root segment, middle root segment and apex segment. The volume of calcium hydroxide in each canal was calculated, and the clearance rate of calcium hydroxide was compared among the groups. SPSS 19.0 software package was used for statistical analysis. RESULTS: None of the three methods could completely remove calcium hydroxide from the root canal. When sodium hypochlorite was used as the flushing solution, the removal effect of ultrasonic group and sonic vibration group was significantly better than that of lateral opening syringe group(P<0.05). The removal efficiency of calcium hydroxide by ultrasonic group and sonic vibration group was similar, and the difference was not statistically significant(P>0.05). The removal rate of calcium hydroxide in apical segment was low. CONCLUSIONS: Micro-CT can reconstruct the molar root canal model efficiently for evaluating the removal effect of calcium hydroxide. The removal efficiency of calcium hydroxide in ultrasonic group and sonic vibration group is similar, and both are better than that in lateral syringe group. Reference | Related Articles | Metrics

Select

Metabolites differences between plaque biofilms of children with different levels of dental caries YANG Yuan-meng, HO Teck-ek, LO Edward Chin Man, MENG Wen, CHEN Xin-yu, WANG Yue, LI Fei, LU Hai-xia Shanghai Journal of Stomatology    2024, 33 (5): 492-499.   DOI: 10.19439/j.sjos.2024.05.009 Abstract （512）      PDF （1492KB）（247）       Knowledge map    PURPOSE: To explore the differences between plaque biofilms of children with different caries activities via metabolomics. METHODS: A case-control study was conducted to investigate the oral health-related behaviors of children in caries-free (CF), low level of early childhood caries(LECC) and high level of early childhood caries (HECC) groups and to collect supragingival plaque biofilms. Untargeted metabolomics was used to detect the compositions of plaque biofilm metabolites in three groups. Orthogonal partial least squares discriminant analysis, volcano plot and heat map were used to analyze the significant differential metabolites between groups with SPSS 26.0 software package. RESULTS: A total of 102 children aged 36 months were included in this study, including 34 children in each group. A total of 660 metabolites belonging to 11 categories were detected. There were statistical differences of 6 metabolites between LECC group and CF group, and 22 metabolites showed statistical differences between HECC group and CF group(P<0.05). Cys Cys Cys Gln, Cys Gln Cys Cys and 5-O-p-coumaroylnigrumin were the common differential metabolites between children with different levels of dental caries. CONCLUSIONS: There are differences in the compositions of plaque biofilms between children with different caries activities and healthy children. Peptides are important differential metabolites within plaque biofilms, also related to oral health. Reference | Related Articles | Metrics

Select

Clincopathological analysis of 171 patients with osteochondroma and malignant transformation in maxillofacial bone LIU Li-min, SUN Jing-jing, QIAN Jia-jun, ZHANG Chun-ye, HU Yu-hua, LI Jiang Shanghai Journal of Stomatology    2024, 33 (3): 324-327.   DOI: 10.19439/j.sjos.2024.03.020 Abstract （500）      PDF （1796KB）（212）       Knowledge map    PURPOSE: To investigate the clinical and pathological features of osteochondroma in maxillofacial region, and to summarize the clinicopathological features of rare osteochondroma malignant transformation in order to provide clinical guidance. METHODS: From January 2018 to September 2023, a total of 171 patients with osteochondroma were retrospectively collected in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Their preoperative CT and clinicopathological features were analyzed. RESULTS: Of the 171 patients with osteochondroma in maxillofacial bone, 66%（113/171） were females and 34% were male. Their age ranged from 11-76 with an average age was 44 years old. Of the 171 cases, 95.3%（163/171）in mandible condyle, 4%(7/171) in mandible processus coronoideus, and 0.5%（1/171） in zygomatic arch. The imaging findings showed that the thickness of cartilaginous cap was less than 1 cm in 98%（159/161） cases with condyle lesions. Only 2 cases(2/171, 1.1%) had malignant transformation. One was diagnosed with secondary chondrosarcoma, another developed low-grade osteosarcoma. CONCLUSIONS: Osteochondroma in maxillofacial region mostly occurs in females, and most commonly located in condylar process, with a malignant change rate of 1.1%, which is similar to that of other parts of the body. Imaging findings have important guiding significance for the diagnosis of osteochondroma malignant change. Reference | Related Articles | Metrics

Select

Evaluation of a modified maxillary protraction appliance for the treatment of patients with skeletal Class Ⅲ malocclusion associated with crowding LIU Ye, GE Xiao-lei, ZHANG Shi-long, QIN Yuan, HOU Yan, LU Hai-yan, MA Wen-sheng Shanghai Journal of Stomatology    2024, 33 (2): 180-185.   DOI: 10.19439/j.sjos.2024.02.013 Abstract （496）      PDF （1149KB）（213）       Knowledge map    PURPOSE: To investigate the efficacy of a modified maxillary protraction appliance in patients of skeletal Class Ⅲ with crowding. METHODS: Forty patients with skeletal Class Ⅲ malocclusion were divided into two groups, with 20 patients in each group. The experimental group had molar in a neutral or distal relationship and applied a modified maxillary protraction appliance, while the control group had molar mesial relationship and applied a conventional maxillary protraction appliance. Lateral cephalometric radiographs were taken before and after treatment in both groups for comparison. SPSS 22.0 software package was used for data analysis. RESULTS: The angle measurements taken before and after treatment showed a significant increase in SNA, ANB, SN-MP and U4-SN(P<0.01), while SNB decreased(P<0.01) in both groups. SN-OL changes were statistically different before and after treatment in the experimental group(P<0.05). The sagittal measurements before and after treatment in both groups showed significant alterations in all(P<0.05) but the length of the maxillary arch in both groups. For vertical measurements, U1-PP, L1-MP, U4-SN, U6-SN, and ANS-ME all increased (P<0.05), while the changes of U4-PP and U6-PP in the two groups before and after treatment were statistically different(P<0.05). Compared with the control group, the experimental group had a significantly increased maxillary arch length, a more remote location at U6, and a less variable molar relationship after treatment(P<0.01). The two groups showed a variable amount of cephalometric measurements before and after treatment: the experimental group had a significant increase in maxillary arch length, a more remote position at U6, and a smaller change in molar relationship compared to the control group(P<0.01). CONCLUSIONS: The modified maxillary protraction appliance showed good results for maxillary protraction and pushing the molar distally in patients with skeletal Class Ⅲ with crowding at neutral or distal molar relationship. Reference | Related Articles | Metrics

Select

Imaging findings in 12 cases of Warthin-like mucoepidermoid carcinoma CHEN Qian-qian, YU Qiang, SUN Jing-jing, XIONG Ping Shanghai Journal of Stomatology    2024, 33 (2): 219-224.   DOI: 10.19439/j.sjos.2024.02.020 Abstract （492）      PDF （1930KB）（178）       Knowledge map    PURPOSE: To summarize the ultrasound, CT and MRI manifestations of Warthin-like mucoepidermoid carcinoma (WT-MEC), and to explore its imaging characteristics, so as to provide reference for clinical and preoperative diagnosis. METHODS: The clinical information and imaging data of ultrasound, CT and MRI of 12 patients with WT-MEC diagnosed by pathology in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2017 to December 2021 were collected, and their specific characteristics were retrospectively summarized. RESULTS: Among the 12 WT-MEC patients, there were 7 males and 5 females, with an average age of (42.7±16) years. Seven cases underwent ultrasound examination, 6 cases underwent CT examination, and 2 cases underwent MRI examination. Radiologically, all the lesions presented as a solitary mass. 11/12 lesions(91.7%) were identified as well-defined margins, and 10/12(83.3%) as solid-cystic masses. All solid-cystic lesions contained multiple cystic areas with variable sizes. On US images, most lesions showed mixed-echoic echogenicity(5/7, 71.4%), poor vascularization (6/7, 85.7%) and acoustic enhancement (6/7, 85.7%). CT revealed all the lesions (6/6, 100%) as a soft-tissue mass with heterogeneous enhancement (5/6, 83.3%). MRI imaging demonstrated the neoplasm with low or iso-signal intensity on plain T1WI and hyperintensity on T2WI. The heterogeneous enhancement was shown on contrast-enhanced T1WI. CONCLUSIONS: Most WT-MECs represent as a solitary, well-defined, solid-cystic mass in the parotid gland. The neoplasm may be characterized by the multiple and variable-sized cystic components within the tumor. Reference | Related Articles | Metrics