三种含漱液混合含漱对糜烂型口腔扁平苔藓患者血清生物标志物和炎症因子水平的影响

doi:10.19439/j.sjos.2025.05.018

摘要/Abstract

摘要： 目的:探讨康复新液、西帕依固龈液和氯己定含漱液混合含漱对糜烂型口腔扁平苔藓（erosive oral lichen planus,EOLP）患者血清生物标志物和炎症因子水平的影响。方法:选择2022年1月—2024年6月长沙市第四医院收治的EOLP患者100例,根据治疗方法分为对照组和试验组,每组各50例。对照组使用西帕依固龈液含漱,试验组使用康复新液、西帕依固龈液、氯己定含漱液混合含漱。比较两组患者治疗前后创口面积、疼痛程度VAS评分、愈合时间及血清生物标志物（AT-Ⅲ、IgM、ZAG）与炎症因子（IL-12、IL-17）水平的变化。结果:试验组创口愈合时间显著短于对照组（P<0.05）。治疗后,试验组创口面积、VAS评分、血清生物标志物（AT-Ⅲ、IgM、ZAG）及炎症因子（IL-12、IL-17）水平优于对照组,差异有统计学意义（P<0.05）。试验组治疗总有效率为96%,显著高于对照组的84%（P<0.05）。两组不良反应发生率无统计学差异（P>0.05）。结论:康复新液、西帕依固龈液、氯己定含漱液联合使用,可有效加速EOLP患者创面愈合,减轻疼痛,抑制炎症反应,具有较高的临床应用价值。

关键词: 糜烂型口腔扁平苔藓, 康复新液, 西帕依固龈液, 氯己定含漱液, 血清生物标志物, 炎症因子

Abstract: PURPOSE: To investigate the effect of a combination of Kangfuxin liquid, Sipaiya gingival liquid, and chlorhexidine mouthwash on the levels of serum biomarkers and inflammatory factors in patients with erosive oral lichen planus (EOLP). METHODS: A total of 100 EOLP patients admitted to the Fourth Hospital of Changsha from January 2022 to June 2024 were selected and divided into control group and experimental group according to treatment methods, with 50 cases in each group. The control group used Sipaiya gingival liquid, while the experimental group used a combination of Kangfuxin liquid, Sipaiya gingival liquid, and chlorhexidine mouthwash. The changes of wound area, pain VAS score, healing time, serum biomarkers (AT-III, IgM, ZAG) and inflammatory factors (IL-12, IL-17) before and after treatment were compared between the two groups. RESULTS: The wound healing time of the experimental group was shorter than that of the control group, with significant difference (P<0.05). After treatment, the experimental group showed significantly better wound area, VAS score, serum biomarkers (AT-III, IgM, ZAG), and levels of inflammatory factors (IL-12, IL-17) compared to the control group (P<0.05). The total effective rate of the experimental group was 96%, which was significantly higher than that of the control group (84%) (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). CONCLUSIONS: The combination of Kangfuxin liquid, Sipaiya gingival liquid and chlorhexidine mouthwash can effectively accelerate wound healing, reduce pain, suppress inflammatory responses, and improve treatment outcomes in EOLP patients, demonstrating high clinical application value.

Key words: Erosive oral lichen planus, Kangfuxin liquid, Sipaiya gingival liquid, Chlorhexidine, Serum biomarkers, Inflammatory factors

中图分类号:

R781.5

岳金宝, 罗玉姣. 三种含漱液混合含漱对糜烂型口腔扁平苔藓患者血清生物标志物和炎症因子水平的影响[J]. 上海口腔医学, 2025, 34(5): 551-556.

Yue Jinbao, Luo Yujiao. Effect on three mouthwashes mixture on serum biomarkers and inflammatory factor levels in the treatment of patients with erosive oral lichen planus[J]. Shanghai Journal of Stomatology, 2025, 34(5): 551-556.

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