上海口腔医学

上海口腔医学 ›› 2018, Vol. 27 ›› Issue (5): 526-529.doi: 10.19439/j.sjos.2018.05.017

• 论著 • 上一篇    下一篇

康复新液联合大蒜素胶囊治疗儿童复发性口腔溃疡的疗效及对免疫调节的影响

马鹏涛1, 吴宁宁2, 裴蓉1   

  1. 1.郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院 口腔科,河南 郑州450053;
    2.郑州大学第一附属医院 口腔科,河南 郑州 450000
  • 收稿日期:2018-03-28 出版日期:2018-10-25 发布日期:2018-11-05
  • 通讯作者: 吴宁宁, E-mail: 307130094@qq.com
  • 作者简介:马鹏涛（1983-）,男,主治医师,E-mail：1300469652@qq.com

Effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer and on immune regulation

MA Peng-tao1, WU Ning-ning2, PEI Rong1   

  1. 1.Department of Stomatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital. Zhengzhou 450053;
    2.Department of Stomatology, the First Affiliated Hospital of Zhengzhou University. Zhengzhou 450000, Henan Province, China
  • Received:2018-03-28 Online:2018-10-25 Published:2018-11-05

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摘要： 目的: 探讨康复新液联合大蒜素胶囊治疗儿童复发性口腔溃疡（ROU）的疗效及对免疫调节的影响。方法: 采用临床随机对照研究方法,选择2015年3月—2017年3月符合2012版ROU诊断标准的患儿204例,随机分为2组,A组接受大蒜素胶囊口服1 粒/次,3 次/d, 联合使用康复新液10 mL含漱3次/d;B组仅予以康复新液10 mL含漱5 min,3次/d,均治疗2周,对比治疗疗效,治疗前、后溃疡面疼痛程度（VAS评分）、溃疡愈合时间,并比较治疗前、后T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+水平。采用SPSS 22.0软件包对数据进行统计学分析。结果: A组溃疡愈合时间（3.5±0.6）d、疼痛持续时间（3.1±0.3）d,均显著短于B组（P<0.05）;2组治疗有效率相比（96.08%∶88.24%）,差异具有统计学意义（χ2=6.264,P<0.05）;2组治疗后疼痛程度均明显减轻,A组与B组[（1.1±0.4）∶（3.2±0.6）]之间差异具有统计学意义（P<0.05）;2组治疗后CD3+、CD4+、CD4+/CD8+均出现上升,CD8+显著下降,与治疗前相比均具有统计学差异（P<0.05）;A组治疗后CD3+、CD4+、CD4+/CD8+水平显著高于B组（P<0.05）,CD8+显著低于B组（P<0.05）。结论: 康复新液联合大蒜素胶囊可提高ROU疗效,促进患儿口腔局部受损黏膜的修复,增加患儿免疫功能。

关键词: 康复新液, 大蒜素胶囊, 复发性口腔溃疡, 免疫调节

Abstract: PURPOSE: To study the effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer (ROU) and on immunological regulation. METHODS: This randomized controlled clinical study prospectively enrolled 204 patients with ROU who were randomly divided into 2 groups. Patients in group A received Garlicin Capsules 1/time, 3 times/d, combined with Kangfuxin liquid 10 mL to gargle 3 times/d; patients in group B only received Kangfuxin liquid 10 mL gargle 5 min, 3/d. The treatment lasted for 2 weeks. The curative effect was compared before and after treatment, including ulcer surface pain (VAS score), time of ulcer healing, and the changes of T cell subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) before and after treatment were compared by SPSS 22 software package. RESULTS: Ulcer healing time (3.5±0.6) d, duration of pain (3.1±0.3)d in group A were shorter than in group B (P<0.05); treatment efficiency was 96.08% in group A, 88.24% in group B( χ2=6.264, P<0.05). The pain scores of both groups were significantly reduced after treatment, and the difference was significant between group A and group B [(1.1±0.4) vs (3.2± 0.6)(P<0.05). The levels of CD3+, CD4+, CD4+/CD8+ in group A were significantly higher than those in group A after treatment (P<0.05), the levels of CD8+ was significant lower than in group B (P<0.05). CONSLUSIONS: Kangfuxin liquid combined with Garlicin Capsules can improve the therapeutic effect of ROU and repair of local damaged mucosa in children, increasing the immune function of children.

Key words: Rehabilitation liquid, Garlicin Capsules, Recurrent oral ulcer, Immune regulation

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