布洛芬辅助治疗重度慢性牙周炎的短期疗效及对龈沟液中细胞因子的影响

doi:10.19439/j.sjos.2017.05.019

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (5): 557-560.doi: 10.19439/j.sjos.2017.05.019

布洛芬辅助治疗重度慢性牙周炎的短期疗效及对龈沟液中细胞因子的影响

孙小娜¹, 宋爱梅^{2, 3, *}, 杨丕山^{2, 3, *}

1.山东大学齐鲁医院（青岛）口腔科,山东青岛 266000；
2.山东大学口腔医学院,山东济南 250012；
3.山东省口腔组织再生重点实验室,山东济南 250012

收稿日期:2017-03-09 修回日期:2017-05-25 出版日期:2017-10-25 发布日期:2017-11-23
通讯作者: 杨丕山,E-mail：yangps@sdu.edu.cn;宋爱梅,E-mail：sam1972@sdu.edu.cn。^*共同通信作者
作者简介:孙小娜（1988-）,女,硕士,E-mail：sunxiaona1988@126.com

Short-term effect of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis

SUN Xiao-na¹, SONG Ai-mei^{2, 3}, YANG Pi-shan^{2, 3}

1.Department of Stomatology, Qilu Hospital of Shandong University Qingdao. Qingdao 266000;
2.School of Stomatology, Shandong University. Jinan 250012;
3.Shandong Provincial Key Laboratory of Oral Tissue Regeneration. Jinan 250012, Shandong Province, China

Received:2017-03-09 Revised:2017-05-25 Online:2017-10-25 Published:2017-11-23

摘要/Abstract

摘要： 目的探讨布洛芬辅助治疗重度慢性牙周炎的短期疗效及对龈沟液中细胞因子的影响。方法将20例重度慢性牙周炎患者随机分为2组,对照组只进行牙周机械治疗,实验组在牙周机械治疗后即日起口服布洛芬缓释胶囊（300 mg bid）,共服用5 d。于实验第0、1、2、4周时分别记录牙周临床指标,同时检测龈沟液中肿瘤坏死因子α（tumor necrosis factor alpha, TNF-α）、骨保护素（osteoprotegerin, OPG）、核因子κB受体活化因子配体（receptor activator of NF-κB ligand, RANKL）水平。采用SPSS 17.0软件包对数据进行统计学分析。结果每个时间点实验组与对照组的牙周临床指标及TNF-α、RANKL、OPG及RANKL/OPG比值均无显著差异（P>0.05）。结论本研究未能显示短期口服布洛芬能够辅助机械清创治疗重度慢性牙周炎。

关键词: 慢性牙周炎, 布洛芬, 肿瘤坏死因子α, 骨保护素, 核因子κ, B受体活化因子配体

Abstract: PURPOSE: To explore the short-term effects of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis. METHODS: Twenty subjects with severe chronic periodontitis but otherwise healthy participated in the study and they were divided into two groups randomly. The patients in the experimental group took ibuprofen 300mg, bid for 5 days after scaling and root planing (SRP), while patients in the control group only underwent SRP. Clinical indexes were recorded at baseline, 1 w, 2 w, 4 w, respectively. Meanwhile, the levels of tumor necrosis factor alpha (TNF-α), osteoprotegerin (OPG) and receptor activator of NF-κB ligand (RANKL) in the gingival crevicular fluid were detected. SPSS 17.0 software package was used for statistical analysis. RESULTS: At each time point, both the clinical data and the levels of TNF-α, RANKL, OPG and RANKL/OPG between the experimental group and the control group were not statistically significant (P>0.05). CONCLUSIONS: We can't disclose the positive effect of ibuprofen's short-term oral administration on the treatment of severe chronic periodontitis.

Key words: Chronic periodontitis, Ibuprofen, TNF-α, RANKL, OPG

中图分类号:

R781.4.2

孙小娜, 宋爱梅, 杨丕山. 布洛芬辅助治疗重度慢性牙周炎的短期疗效及对龈沟液中细胞因子的影响[J]. 上海口腔医学, 2017, 26(5): 557-560.

SUN Xiao-na, SONG Ai-mei, YANG Pi-shan. Short-term effect of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis[J]. Shanghai Journal of Stomatology, 2017, 26(5): 557-560.

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布洛芬辅助治疗重度慢性牙周炎的短期疗效及对龈沟液中细胞因子的影响

Short-term effect of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis

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