上海口腔医学

上海口腔医学 ›› 2015, Vol. 24 ›› Issue (5): 415-419.

• 临床研究 • 上一篇    下一篇

TPF诱导化疗对局部晚期口腔鳞癌患者生活质量的影响

俞聪, 刘莹, 乔金科, 谈亦然, 马捷, 殷秋明, 蔡以理, 孙坚, 张陈平, 张志愿, 钟来平   

  1. 上海交通大学医学院附属第九人民医院·口腔医学院 口腔颌面-头颈肿瘤科, 上海市口腔医学重点实验室,上海 200011
  • 收稿日期:2015-04-17 修回日期:2015-06-18 出版日期:2015-10-20 发布日期:2015-11-03
  • 通讯作者: 钟来平,Tel：021-23271699-5160,E-mail:zhonglaiping@163.com
  • 作者简介:俞聪（1987- ）,男,在读硕士研究生,E-mail：675880465@qq.com

Effect of TPF induction chemotherapy on quality of life in patients with locally advanced oral squamous cell carcinoma

YU Cong, LIU Ying, QIAO Jin-ke, TAN Yi-ran, MA Jie, YIN Qiu-ming, CAI Yi-li, SUN Jian, ZHANG Chen-ping, ZHANG Zhi-yuan, ZHONG Lai-ping   

  1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China
  • Received:2015-04-17 Revised:2015-06-18 Online:2015-10-20 Published:2015-11-03

摘要： 目的评估TPF（紫杉醇、顺铂、氟尿嘧啶）诱导化疗对局部晚期可切除口腔鳞癌患者生活质量的影响。方法选择2008年3月—2010年12月收治的临床Ⅲ期或ⅣA期原发口腔鳞癌患者256例,随机分为2组,每组128例;试验组为TPF诱导化疗加手术和术后放疗,对照组为手术加术后放疗。运用EORTC QLQ-C30和QLQ-HN35量表对所有患者的生活质量进行评估,采用SAS 9.2软件包对数据进行统计学分析。结果256例入组患者中,243例患者至少有1张有效问卷。QLQ-C30的总健康状况和QLQ-HN35的疼痛、吞咽、感觉、语言、进食、社交障碍、性功能减退在试验组和对照组之间无显著差异。治疗后3个月,试验组患者的开口问题比对照组严重,但总体评价显示组间差异无统计学意义(P>0.05)。结论TPF诱导化疗对局部晚期口腔鳞癌患者的生活质量无显著影响。

关键词: 口腔鳞癌, 生活质量, 诱导化疗

Abstract: PURPOSE:To evaluate the effect of TPF (docetaxel, cisplatin, and 5-fluorouracil) induction chemotherapy on quality of life (QOL) in patients with locally advanced oral squamous cell carcinoma (OSCC). METHODS: Two hundred and fifty-six primary OSCC patients in stage Ⅲ or ⅣA recruited from March 2008 to December 2010 were randomized into 2 groups, 128 in each group. The experimental group underwent TPF induction chemotherapy followed by radical surgery and postoperative radiotherapy, the control group underwent radical surgery and postoperative radiotherapy. The QOL was assessed using the questionnaire of EORTC QLQ-C30 and QLQ-HN35. The data was analyzed using SAS 9.2 software package. RESULTS: Among 256 patients enrolled in this trial, 243 patients had at least one valid QOL form. There was no significant difference between the patients in the experimental group and control group on the global health status in the QLQ-C30 and the symptoms of pain, swallowing, sense, speech, eating, social contact, and sexuality in the QLQ-HN35 questionnaire. Although the symptom of mouth opening in the QLQ-HN35 was better in the control group than the experimental group at the third month after treatment, the final difference of mouth opening between the 2 groups was not significant (P>0.05). CONCLUSIONS: The addition of TPF induction chemotherapy has not significant effect on the QOL in patients with locally advanced OSCC when treated by radical surgery and postoperative radiotherapy.

Key words: Supported by National Natural Science Foundation of China (81472519), Shanghai Talent Development Fund (201447), and Research Fund of Science and Technology Committee of Shanghai Municipality (13QH1401700).