上海口腔医学

上海口腔医学 ›› 2024, Vol. 33 ›› Issue (3): 324-327.doi: 10.19439/j.sjos.2024.03.020

• 临床总结 • 上一篇    下一篇

171例颌面部骨软骨瘤及恶变病例临床病理分析

刘丽敏, 孙晶晶, 钱佳骏, 张春叶, 胡宇华, 李江   

  1. 上海交通大学医学院附属第九人民医院 口腔病理科,上海交通大学口腔医学院,国家口腔医学中心, 国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011
  • 收稿日期:2023-12-11 修回日期:2024-01-25 出版日期:2024-06-25 发布日期:2024-07-11
  • 通讯作者: 李江,E-mail: lijiang182000@126.com
  • 作者简介:刘丽敏（1989-）,女,博士,E-mail: 798941818@qq.com

Clincopathological analysis of 171 patients with osteochondroma and malignant transformation in maxillofacial bone

LIU Li-min, SUN Jing-jing, QIAN Jia-jun, ZHANG Chun-ye, HU Yu-hua, LI Jiang   

  1. Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology. Shanghai 200011, China
  • Received:2023-12-11 Revised:2024-01-25 Online:2024-06-25 Published:2024-07-11

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摘要： 目的：探讨颌面部骨软骨瘤（osteochondroma）的临床及病理特征,总结罕见的骨软骨瘤恶变患者的临床病理特点,为临床诊治提供指导。方法：回顾性收集2018年1月—2023年8月上海交通大学医学院附属第九人民医院手术治疗的171例骨软骨瘤患者,总结分析临床、影像及病理学特点。结果：171例骨软骨瘤患者中,66%（113/171）为女性,34%（58/171）为男性,发病年龄11~76岁,平均44岁。95.3%（163/171）发生于髁突,4%（7/171）发生于冠突,0.5%（1/171）发生于颧弓。98%（159/161）的髁突骨软骨帽厚度小于1 cm。171例骨软骨瘤中,2例（2/171,1.1%）发生恶变,1例恶变为软骨肉瘤（Ⅰ级）,1例恶变为高分化骨肉瘤。结论：颌面部骨软骨瘤多发生于女性,以髁突最常见,恶变率为1.1%,与全身其他部位骨软骨恶变率相当。影像学表现对骨软骨瘤恶变的诊断具有重要意义。

关键词: 颌面部, 髁突, 骨软骨瘤, 恶变

Abstract: PURPOSE: To investigate the clinical and pathological features of osteochondroma in maxillofacial region, and to summarize the clinicopathological features of rare osteochondroma malignant transformation in order to provide clinical guidance. METHODS: From January 2018 to September 2023, a total of 171 patients with osteochondroma were retrospectively collected in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Their preoperative CT and clinicopathological features were analyzed. RESULTS: Of the 171 patients with osteochondroma in maxillofacial bone, 66%（113/171） were females and 34% were male. Their age ranged from 11-76 with an average age was 44 years old. Of the 171 cases, 95.3%（163/171）in mandible condyle, 4%(7/171) in mandible processus coronoideus, and 0.5%（1/171） in zygomatic arch. The imaging findings showed that the thickness of cartilaginous cap was less than 1 cm in 98%（159/161） cases with condyle lesions. Only 2 cases(2/171, 1.1%) had malignant transformation. One was diagnosed with secondary chondrosarcoma, another developed low-grade osteosarcoma. CONCLUSIONS: Osteochondroma in maxillofacial region mostly occurs in females, and most commonly located in condylar process, with a malignant change rate of 1.1%, which is similar to that of other parts of the body. Imaging findings have important guiding significance for the diagnosis of osteochondroma malignant change.

Key words: Maxillofacial region, Condyle, Osteochondroma, Malignant transformation

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