Effect of chronic periodontitis on quality of life and severity in patients with bronchiectasis

doi:10.19439/j.sjos.2024.02.014

Abstract

Abstract: PURPOSE: To investigate the effects of chronic periodontitis on the quality of life and severity of the disease in patients with bronchiectasis. METHODS: A total of 80 bronchiectasis patients admitted to The Fourth Hospital of Changsha between April 2021 and April 2023 were randomly selected. Patients were divided into two groups according to whether they had moderate to severe chronic periodontitis: bronchiectasis with periodontitis group (n=45) and bronchiectasis without periodontitis group (n=35). The Qualify of Life Questionnaire for Bronchiectasi(QoL-B) was used to assess patients' quality. The severity of the disease was assessed using the Bronchiectasis Severity Index (BSI), and serum levels of hypersensitive C-reactive protein (hsCRP), tumor necrosis factor alpha(TNF-alpha), and interleukin-6(IL-6) were detected. SPSS 20.0 software package was used for data analysis. RESULTS: The QoL-B score of bronchiectasis with periodontitis group was significantly lower than that of bronchiectasis without periodontitis group, and the BSI score was significantly higher than that of bronchiectasis without periodontitis group(P<0.05). The levels of hs-CRP, TNF-alpha and IL-6 in bronchiectasis with periodontitis were significantly higher than those in bronchiectasis without periodontitis group(P<0.05). CONCLUSIONS: Chronic periodontitis shows significant adverse effects on both quality of life and disease severity in patients with bronchiectasis, which may be related to the common mechanism of inflammatory response between the two kinds of diseases.

Key words: Chronic periodontitis, Bronchiectasis, Qualify of life, hs-CRP, TNF-ɑ, IL-6

CLC Number:

R781.4

LEI Deng, ZHOU Ying-bin, TANG Sheng-bin, LI Yu-feng. Effect of chronic periodontitis on quality of life and severity in patients with bronchiectasis[J]. Shanghai Journal of Stomatology, 2024, 33(2): 186-189.

References

[1] Gupta A, Singh N, Kumar A, et al.Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients[J]. Mol Biol Res Commun, 2020, 9(4): 169-172.
[2] Sapey E, Yonel Z, Edgar R, et al.The clinical and inflammatory relationships between periodontitis and chronic obstructive pulmonary disease[J]. J Clin Periodontol, 2020, 47(9): 1040-1052.
[3] Kouanda B, Sattar Z, Geraghty P.Periodontal diseases: major exacerbators of pulmonary diseases?[J]. Pulm Med, 2021, 2021: 4712406.
[4] 支气管扩张症专家共识撰写协作组, 中华医学会呼吸病学分会感染学组. 中国成人支气管扩张症诊断与治疗专家共识[J]. 中华结核和呼吸杂志, 2021, 44(4): 311-321.
[5] Quittner AL, Marciel KK, Salathe MA, et al.A preliminary quality of life questionnaire-bronchiectasis: a patient-reported outcome measure for bronchiectasis[J]. Chest, 2014, 146(2): 437-448.
[6] 刘珂, 艾合买提·艾尼娃, 图尔妮萨古丽·克比尔, 等. 二甲双胍联合DPP-4抑制剂对2型糖尿病伴慢性牙周炎患者牙槽骨密度的影响[J].上海口腔医学, 2023, 32(4): 410-416.
[7] Martínez-García M, Castrejón-Pérez RC, Rodríguez-Hernández AP, et al.Incidence of arterial hypertension in people with periodontitis and characterization of the oral and subgingival microbiome: a study protocol[J]. Front Cardiovasc Med, 2022, 8: 763293.
[8] Rosa RAC, Rodrigues JVS, Cláudio MM, et al.The relationship between hypertension and periodontitis: a cross-sectional study[J]. J Clin Med, 2023, 12(15): 5140.
[9] Zhang D, Liu W, Miao R, et al.Chronic periodontitis is a risk factor of renal dysfunction in patients with type 2 diabetes[J]. Exp Clin Endocrinol Diabetes, 2021, 129(6): 407-412.
[10] Eslami S, Hosseinzadeh Shakib N, Fooladfar Z, et al.The role of periodontitis-associated bacteria in Alzheimer's disease: a narrative review[J]. J Basic Microbiol, 2023, 63(10): 1059-1072.
[11] Kibkalo AP, Sarkisov AK, Polunina EA, et al.The level of oxidative stress markers in generalised periodontitis in the setting of bronchiectasis[J]. Kuban Scientific Medical Bulletin, 2019, 26(5): 42-51.
[12] 文富强, 曾妮. 支气管扩张症-慢性阻塞性肺疾病重叠综合征研究进展[J]. 西部医学, 2017, 29(1): 1-3,12.
[13] Tiotiu A, Martinez-Garcia MA, Mendez-Brea P, et al.Does asthma-bronchiectasis overlap syndrome(ABOS) really exist?[J] J Asthma, 2023, 60(11): 1935-1941.
[14] Li S, Wang L, Chang N, et al.Differential clinical and CT imaging features of pneumonic-type primary pulmonary lymphoma and pneumonia: a retrospective multicentre observational study[J]. BMJ Open, 2023, 13(10): e077198.
[15] 李鑫, 李艳, 丁旭, 等. 内质网应激在牙周炎影响全身疾病过程中的作用[J]. 国际口腔医学杂志, 2021, 48(1): 12-17.
[16] Gupta A, Verma UP, Verma AK, et al.A retrospective correlative profiling of lung functions, microbiological, radiological, periodontal, hematological parameters in noncystic fibrosis bronchiectasis patients of North India[J]. Natl J Maxillofac Surg, 2022, 13(1): 44-53.
[17] 张力木, 林晓萍. C反应蛋白介导的牙周炎与全身系统性疾病相关机制研究进展[J].口腔疾病防治, 2020, 28(3): 184-188.
[18] Oscullo G, Gómez-Olivas JD, Ingles M, et al.Bronchiectasis-COPD overlap syndrome: role of peripheral eosinophil count and inhaled corticosteroid treatment[J]. J Clin Med, 2023, 12(19): 6417.
[19] Triananda RS, Carolina DN, Amaliya A.Relationship between periodontitis with commorbid disease to the severity of Covid-19 infection: a scoping review[J]. J Int Dent Med Res, 2022, 15(4): 1816-1821.
[20] de Camargo AA, de Castro RAS, Vieira RP, et al. Systemic inflammation and oxidative stress in adults with bronchiectasis: association with clinical and functional features[J]. Clinics (Sao Paulo), 2021, 76: e2474.
[21] Zhang Y, Jia R, Zhang Y, et al.Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis[J]. BMC Oral Health, 2023, 23(1): 717-736.