Abstract: PURPOSES: To analyze the effect of low level laser treatment combined with basic therapy periodontal on cytokines and lipopolysaccharide, leptin in gingival sulcus of patients with diabetes mellitus complicated with chronic periodontitis (DMCP). METHODS: From January 2016 to January 2017, 80 patients with DMCP were randomly divided into experimental group and control group. Patients in the control group received basic periodontal therapy, while patients in the experimental group received low dose laser combined with basic periodontal treatment. Before treatment and 3 months after treatment, oral PD, SBI and CAL levels were detected in all patients. Venous blood was collected, HbA1c and FPG levels in blood serum were detected. TNF-α, IL-1, hs-CRP, LPS, leptin in gingival crevicular fluid were detected. Statistical analyses were performed using SPSS19.0 software package. RESULTS: After treatment, CAL, PD, SBI, FBG, HbA1c, TNF-α, IL-1, hs-CRP, LPS levels were significantly decreased, Leptin level increased in both group, and the difference was significant (P<0.05). After treatment, CAL, PD, SBI, FBG, HbA1c, TNF-α, hs-CRP, IL-1 and the level of LPS in the experimental group was significantly lower than the control group (P<0.05), and the level of leptin was significantly higher than that of the control group (P<0.05). CONCLUSIONS: Low level laser combined with basic periodontal treatment can effectively reduce LPS level of DMCP patients in gingival sulcus, and improve the level of Leptin, significantly improve the inflammatory reaction and clinical efficacy.

Key words: Low level laser, Basic periodontal treatment, Diabetes mellitus complicated with chronic periodontitis, Lipopolysaccharide, Leptin