The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus

doi:10.19439/j.sjos.2018.06.014

Abstract

Abstract: PURPOSE: To observe the curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus. METHODS: Fifty patients with severe periodontitis and diabetes mellitus were randomly divided into 2 groups. The patients in the control group were treated with scaling and root planning(SRP); while patients in the experimental group were treated with SRP followed by topical use of rhubarb extract. Periodontal index probing pocket depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were examined before periodontal treatment,6 weeks and 12 weeks after treatment. SPSS 20.0 software package was used for statistical analysis. RESULTS: Significant improvement in periodontal condition was noted in both groups after treatment, and the degree of improvement was greater in the experimental group than in the control group. No adverse event during the entire study was found. CONCLUSIONS: Topical application of rhubarb extract for the treatment of severe periodontitis with diabetes has good clinical efficacy.

Key words: Rhubarb extract, Severe periodontitis, Diabetes, Clinical efficacy

CLC Number:

R781.4.2

LI Yue-ling, LI Yi-fan, ZHOU Yu-zong, YANG Jia-yin, RAN Xing. The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus[J]. Shanghai Journal of Stomatology, 2018, 27(6): 633-636.

References

[1] Löe H.Periodontal disease. The sixth complication of diabetes mellitus[J]. Diabetes Care, 1993, 16(1): 329-334.
[2] Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2003, 26(Suppl 1): S5-S20.
[3] Casanova L, Hughes FJ, Preshaw PM.Diabetes and periodontal disease: a two-way relationship[J]. Br Dent J, 2014, 217(8): 433-437.
[4] Preshaw PM, Alba AL, Herrera D, et al.Periodontitis and diabetes: a two-way relationship[J]. Diabetologia, 2012, 55(1): 21-31.
[5] Engebretson SP, Hey-Hadavi J, Ehrhardt FJ, et al.Gingival crevicular fluid levels of interleukin-1beta and glycemic control in patients with chronic periodontitis and type 2 diabetes[J]. J Periodontol, 2004, 75(9): 1203-1208.
[6] Naguib G, Al-Mashat H, Desta T, et al.Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation[J]. J Invest Dermatol, 2004, 123(1): 87-92.
[7] Winning L, Patterson CC, Neville CE, et al.Periodontitis and incident type 2 diabetes: a prospective cohort study[J]. J Clin Periodontol, 2017, 44(3): 266-274.
[8] Taylor GW, Borgnakke WS.Periodontal disease: associations with diabetes, glycemic control and complications[J]. Oral Dis, 2008, 14(3): 191-203.
[9] Mealey BL, Oates TW.Diabetes mellitus and periodontal diseases[J]. J Periodontol, 2006, 77(8): 1289-1303.
[10] Pradhan S, Goel K.Interrelationship between diabetes and periodontitis: a review[J]. JNMA J Nepal Med Assoc, 2011, 51(183): 144-153.
[11] 于建玉, 廖欣, 丁厚伟, 等. 中药大黄药理作用研究进展及其临床应用[J]. 中国现代药物应用, 2016, 10(11): 286-287.
[12] 朋汤义, 杨勤军. 《伤寒杂病论》中大黄的应用[J]. 河南中医, 2018, 38(3): 336-338.
[13] 张慧林, 赵妍. 大黄的药理作用及临床应用分析[J]. 光明中医, 2015, 33(5): 1119-1121.
[14] 王文风, 陈聪敏, 陈琼华, 等. 大黄的生化学研究XXXIX.蒽醌衍生物抗厌氧菌的实验研究[J]. 中国药科大学学报, 1990, 21(6): 354-357.
[15] 黄霞, 谭红, 黄定明, 等. 天然药物对牙龈卟啉单胞菌的体外抗菌研究[J]. 中国微生态学杂志, 2005, 17(5): 346-347.
[16] 刘学伟, 崔晓光, 穆宏. 中药大黄辅助治疗慢性牙周炎的疗效观察[J]. 北京口腔医学, 2009, 17(5): 272-273.
[17] 周远鹏, 江京莉. 大黄的药理研究概述[J]. 中药药理与临床, 1991, 7(4): 41-48.