基质细胞衍生因子1α联合富血小板纤维蛋白治疗恒牙撕脱伤效果评价

doi:10.19439/j.sjos.2026.02.011

摘要/Abstract

摘要： 目的:评价基质细胞衍生因子1α（stromal cell-derived factor 1α,SDF-1α）联合富血小板纤维蛋白（platelet-rich fibrin,PRF）治疗恒牙撕脱伤的临床效果。方法:选择2022年4月—2024年1月收治的恒牙撕脱伤患者72例（患牙78颗）,采用随机数字表法分为试验组36例（患牙40颗）和对照组36例（患牙38颗）。两组患者均进行脱位牙再植术,牙槽窝预备后,对照组填充PRF,试验组填充PRF联合SDF-1α。比较两组再植成功率、治疗后咬合痛、生长因子[血管内皮生长因子（vascular endothelial growth factor,VEGF）、血小板源生长因子（platelet-derived growth factor,PDGF）、转化生长因子β（transforming growth factor Beta,TGF-β）、成纤维细胞生长因子（fibroblast growth factor,FGF）]、炎症因子[可溶性细胞间黏附分子1（soluble intercellular adhesion molecule 1,sICAM-1）、白细胞介素6（interleukin 6,IL-6）、C反应蛋白（C-reactive protein,CRP）]和并发症发生情况。结果:试验组再植成功率为100.00%（40/40）,显著高于对照组的89.47%（34/38）（P<0.05）。治疗后1周、1个月、6个月、12个月,两组疼痛程度评分逐渐下降（P<0.05）;治疗后1周、1个月,试验组疼痛程度评分显著低于对照组（P<0.05）;治疗后6个月、12个月,两组疼痛程度评分相比无显著差异（P>0.05）。治疗后,两组VEGF、PDGF、TGF-β和FGF显著高于治疗前,试验组显著高于对照组（P<0.05）。治疗后,两组sICAM-1显著高于治疗前（P<0.05）,IL-6、CRP显著低于治疗前（P<0.05）;试验组治疗后sICAM-1显著高于对照组（P<0.05）,IL-6、CRP显著低于对照组（P<0.05）。两组治疗后并发症发生率相比无显著差异。结论:SDF-1α联合PRF治疗恒牙撕脱伤,能够提高脱位牙再植成功率,减轻治疗后疼痛反应,疗效和安全性良好。

关键词: 基质细胞衍生因子1α, 富血小板纤维蛋白, 恒牙撕脱

Abstract: PURPOSE: To evaluate the clinical effect of stromal cell-derived factor 1α (SDF-1α) combined with platelet-rich fibrin (PRF) in the treatment of permanent tooth avulsion. METHODS: A total of 72 patients (78 affected teeth) with permanent tooth avulsion who were admitted from April 2022 to January 2024 were selected and divided into the experimental group (36 cases, 40 affected teeth) and the control group (36 cases, 38 affected teeth) by random number table method.Both groups of patients underwent replantation treatment,after alveolar socket preparation, the control group was filled with PRF, and the experimental group was filled with PRF combined with SDF-1α. The success rate of replantation, postoperative occlusal pain, levels of growth factors [vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), fibroblast growth factor (FGF)], inflammatory factors [soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), C-reactive protein (CRP)] and complications were compared between the two groups. Results: The replantation success rate of the experimental group was 100.00% (40/40), significantly higher than that of the control group, which was 89.47%(34/38)(P<0.05).One week, one month, six months and twelve months after treatment, the pain degree scores of the two groups gradually decreased (P<0.05). One week and one month after treatment, the pain degree score of the experimental group was significantly lower than that of the control group (P<0.05). At 6 months and 12 months after treatment, there was no significant difference in the pain degree scores between the two groups (P>0.05). After treatment, the levels of VEGF, PDGF, TGF-βand FGF in both groups were significantly higher than those before operation, and the experimental group was significantly higher than the control group(P<0.05). After treatment, sICAM-1 in both groups was significantly higher than that before operation (P<0.05), IL-6 and CRP were significantly lower than those before operation(P<0.05). The postoperative sICAM-1 in the experimental group was significantly higher than that in the control group(P<0.05), and the levels of IL-6 and CRP were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups. CONCLUSIONS: Treatment of permanent tooth avulsion with SDF-1α combined with PRF can improve the replantation success rate of avulsed teeth, reduce postoperative pain responses, with good efficacy and safety.

Key words: Stromal cell-derived factor 1α, Platelet-rich fibrin, Permanent tooth avulsion

中图分类号:

R782.1

郭苏子, 苑春丽, 乌力吉图, 刘静. 基质细胞衍生因子1α联合富血小板纤维蛋白治疗恒牙撕脱伤效果评价[J]. 上海口腔医学, 2026, 35(2): 176-180.

Guo Suzi, Yuan Chunli, Wuli Jitu, Liu Jing. Evaluation of the effect of stromal cell-derived factor 1α combined with platelet-rich fibrin in the treatment of permanent tooth avulsion[J]. Shanghai Journal of Stomatology, 2026, 35(2): 176-180.

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