上海口腔医学

上海口腔医学 ›› 2026, Vol. 35 ›› Issue (2): 181-184.doi: 10.19439/j.sjos.2026.02.012

• 论著 • 上一篇    下一篇

可吸收蛋白胶原缝线对口腔种植手术创口愈合及龈沟液炎症因子的影响

梁清沛, 郑睿   

  1. 重庆市大足区人民医院 口腔科,重庆 402360
  • 收稿日期:2025-03-04 修回日期:2025-04-25 出版日期:2026-04-25 发布日期:2026-04-27
  • 通讯作者: 郑睿,E-mail:578984874@qq.com
  • 作者简介:梁清沛（1990—）,男,本科,住院医师,E-mail:vgri649@163.com
  • 基金资助:
    重庆市科卫联合医学科研项目（2021MSXM114）

Effect of absorbable protein collagen suture on wound healing and inflammatory factors in gingival crevicular fluid in oral implant surgery

Liang Qingpei, Zheng Rui   

  1. Department of Stomatology, Chongqing Dazu District People's Hospital. Chongqing 402360, China
  • Received:2025-03-04 Revised:2025-04-25 Online:2026-04-25 Published:2026-04-27

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摘要： 目的:探讨可吸收蛋白胶原缝线对口腔种植手术创口愈合及龈沟液炎症因子的影响。方法:选择2018年3月—2019年10月重庆市大足区人民医院收治的口腔种植患者128例,采用随机数字表分为可吸收组（可吸收胶原蛋白缝线缝合）和常规组（常规缝合线缝合）,每组各64例。比较两组患者切口愈合时间、术后疼痛程度、切口愈合等级、并发症发生率、龈沟液中肿瘤坏死因子α（tumor necrosis factor-alpha,TNF-α）、白细胞介素6（interleukin-6,IL-6）和白细胞介素8（interleukin-8,IL-8）水平的差异。结果:可吸收组患者切口愈合时间显著短于常规组（P<0.05）,术后1、2 天,可吸收组患者疼痛程度显著轻于常规组（P<0.05）。可吸收组患者甲级切口愈合率为96.88%、乙级切口愈合率为3.13%,常规组甲级切口愈合率为81.25%、乙级切口愈合率为17.19%、丙级切口愈合率为1.56%,可吸收组显著优于常规组（P<0.05）。术前,可吸收组和常规组患者龈沟液中TNF-α、IL-6和IL-8水平相比无显著差异（P>0.05）;术后3天,可吸收组患者龈沟液中TNF-α、IL-6和IL-8水平显著低于常规组（P<0.05）。可吸收组患者并发症发生率（6.25%）显著低于常规组（18.75%）。结论:可吸收胶原蛋白缝线用于口腔种植创口缝合,有利于切口愈合、减轻术后疼痛及炎症反应程度。

关键词: 可吸收, 胶原蛋白缝线, 种植修复, 龈沟液, 炎症因子

Abstract: PURPOSE: To investigate the effect of absorbable protein collagen suture on wound healing and inflammatory factors in gingival crevicular fluid in oral implant surgery. METHODS: A total of 128 patients with oral implants admitted to the People's Hospital of Dazu District, Chongqing City from March 2018 to October 2019 were selected and divided into the absorbable group (sutured with absorbable collagen suture) and the conventional group (sutured with conventional suture) using a random number table, with 64 cases in each group. The incision healing time, postoperative pain degree of patients, incision healing grade, incidence of complications, level of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in gingival crevicular fluid of the two groups of patients were compared. Results: The incision healing time of patients in the absorbable group was significantly shorter than that in the conventional group (P<0.05); at 1 and 2 days after operation, the degree of pain in the absorbable group was significantly less than that in the conventional group (P<0.05). The healing rate of grade A incision in the absorbable group was 96.88%, and that of grade B incision was 3.13%; in the conventional group, the healing rate of grade A incision was 81.25%, grade B incision was 17.19%, and grade C incision was 1.56%, the absorbable group was significantly better than the conventional group(P<0.05). Before operation, there was no significant difference in the levels of TNF-α, IL-6 and IL-8 in the gingival crevicular fluid between the absorbable group and the conventional group (P>0.05). Three days after operation, the levels of TNF-α, IL-6 and IL-8 in the gingival crevicular fluid of the absorbable group were significantly lower than those of the conventional group (P<0.05). The incidence of complications in the absorbable group (6.25%) was significantly lower than that in the conventional group (18.75%). CONCLUSIONS: The use of absorbable collagen suture during oral implant surgery is conducive to incision healing, reducing postoperative pain and inflammatory reaction.

Key words: Absorbable, Collagen suture, Implant repair, Gingival crevicular fluid, Inflammatory factors

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