小肠黏膜下层可吸收生物膜在牙槽骨缺损修复中的应用效果评价

doi:10.19439/j.sjos.2024.03.012

上海口腔医学 ›› 2024, Vol. 33 ›› Issue (3): 279-284.doi: 10.19439/j.sjos.2024.03.012

小肠黏膜下层可吸收生物膜在牙槽骨缺损修复中的应用效果评价

张民珍, 邝惠芳, 杨黎艳, 罗文

海南医学院第一附属医院口腔科,海南海口 570102

收稿日期:2023-06-27 修回日期:2023-09-18 出版日期:2024-06-25 发布日期:2024-07-11
通讯作者: 罗文, E-mail：luowen228@163.com
作者简介:张民珍（1988-）,女,硕士研究生,主治医师,E-mail：mzzhang2011@163.com
基金资助:
海南省自然科学基金（822RC828）

Application of small intestinal submucosa absorbable biofilm in the repair of alveolar bone defects

ZHANG Min-zhen, KUANG Hui-fang, YANG Li-yan, LUO Wen

Department of Stomatology, First Affiliated Hospital of Hainan Medical College. Haikou 570102, Hainan Province, China

Received:2023-06-27 Revised:2023-09-18 Online:2024-06-25 Published:2024-07-11

摘要/Abstract

摘要： 目的：探讨小肠黏膜下层（small intestinal submucosa,SIS）可吸收生物膜在牙槽骨缺损修复的临床疗效。方法：选择2020年1月—2022年1月接受引导骨再生术（guided bone regeneration,GBR）的102例牙槽骨缺损患者,采用计算机随机数字生成器分为Bio-Gide组（51例,采用Bio-Gide可吸收生物膜）和SIS组（51例,采用SIS可吸收生物膜）。比较2组围术期相关指标、血钙、血磷、生物相容性、牙周附着丧失（periodontal attachment loss,PAL）长度、牙髓敏感度、牙松动度、牙槽骨骨量及不良事件。采用SPSS 24.0软件包对数据进行统计学分析。结果：2组手术时间、术中出血量、术后第1天疼痛视觉模拟量表（VAS）评分、术后第5天VAS评分,术前、术后1 d、术后12 d血钙、血磷水平,术前、术后3个月、术后6个月、术后12个月PAL长度,术后3、6、12个月牙髓敏感度及牙松动度1级、2级百分率,术后12个月骨宽度增加量、骨高度增加量,不良事件发生率相比,差异均无统计学意义（P>0.05）。与Bio-Gide组相比,SIS组创口愈合时间、生物膜吸收时间显著缩短（P<0.05）,术后12 d排异反应发生率显著降低（P<0.05）。结论：SIS可吸收生物膜、Bio-Gide可吸收生物膜在牙槽骨缺损修复GBR中的效果及安全性相当,但前者生物相容性更佳,后者可提供更长时间的屏障功能。

关键词: 牙槽骨缺损修复, 小肠黏膜下层可吸收生物膜, Bio-Gide可吸收生物膜, 引导骨再生术

Abstract: PURPOSE: To study the clinical efficacy of small intestinal submucosa (SIS) absorbable biological membrane in alveolar bone defect repair. METHODS: A total of 102 patients with alveolar bone defect who received guided bone regeneration (GBR) in our hospital from January 2020 to January 2022 were selected and divided into Bio-Gide group (51 cases using Bio-Gide absorbable biofilm) and SIS group (51 cases using SIS absorbable biofilm) by computer random number generator. The perioperative related indicators, blood calcium, blood phosphorus, biocompatibility, periodontal attachment loss (PAL) length, pulp sensitivity, tooth mobility, alveolar bone volume and adverse events of the two groups were compared. Statistical analysis was performed with SPSS 24.0 software package. RESULTS: There was no significant difference in operation time, intraoperative blood loss, visual analogue scale (VAS) score of pain on the first day after operation, VAS score on the fifth day after operation, wound healing time, blood calcium and phosphorus levels before operation, 1 d and 12 d after operation, PAL length before operation, 3 months, 6 months and 12 months after operation, pulp sensitivity and tooth looseness grade 1 and 2 percentage at 3, 6 and 12 months after operation, bone width increase, bone height increase at 12 months after operation and adverse event rate between the two groups (P>0.05). Compared with Bio-Gide group, the wound healing time and biofilm absorption time were shortened in SIS group(P<0.05), and the incidence of rejection was decreased 12 d after operation (P<0.05). CONCLUSIONS: SIS absorbable biofilm and Bio-Gide absorbable biofilm have similar efficacy and safety in repairing GBR for alveolar bone defects, but the former is more biocompatible and the latter can provide longer barrier function.

Key words: Alveolar bone defect repair, Small intestinal submucosa absorbable biological membrane, Bio-Gide absorbable biological membrane, Guided bone regeneration

中图分类号:

R781.2

张民珍, 邝惠芳, 杨黎艳, 罗文. 小肠黏膜下层可吸收生物膜在牙槽骨缺损修复中的应用效果评价[J]. 上海口腔医学, 2024, 33(3): 279-284.

ZHANG Min-zhen, KUANG Hui-fang, YANG Li-yan, LUO Wen. Application of small intestinal submucosa absorbable biofilm in the repair of alveolar bone defects[J]. Shanghai Journal of Stomatology, 2024, 33(3): 279-284.

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小肠黏膜下层可吸收生物膜在牙槽骨缺损修复中的应用效果评价

Application of small intestinal submucosa absorbable biofilm in the repair of alveolar bone defects

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