甲硝唑联合米诺环素在局限性牙周炎种植牙术后感染中的应用效果评价

doi:10.19439/j.sjos.2023.05.015

上海口腔医学 ›› 2023, Vol. 32 ›› Issue (5): 532-535.doi: 10.19439/j.sjos.2023.05.015

甲硝唑联合米诺环素在局限性牙周炎种植牙术后感染中的应用效果评价

张世坤, 裴冬冬, 姜丹丹, 张丽华, 蔡建英, 常忠福

上海市浦东新区人民医院口腔科,上海 201299

收稿日期:2023-04-17 修回日期:2023-05-09 出版日期:2023-10-25 发布日期:2023-11-03
通讯作者: 常忠福,E-mail：czf315@126.com
作者简介:张世坤（1989-）,女,硕士,主治医师,E-mail: shikun27@sina.com

Application of metronidazole combined with minocycline in reducing infection after dental implant in patients with localized periodontitis

ZHANG Shi-kun, PEI Dong-dong, JIANG Dan-dan, ZHANG Li-hua, CAI Jian-ying, CHANG Zhong-fu

Department of Stomatology, People’s Hospital of Shanghai Pudong District. Shanghai 201299, China

Received:2023-04-17 Revised:2023-05-09 Online:2023-10-25 Published:2023-11-03

摘要/Abstract

摘要： 目的：探讨甲硝唑联合米诺环素在降低局限性牙周炎种植牙术后感染中的应用价值。方法：选择2021年8月—2022年9月上海市浦东新区人民医院口腔科行牙种植的局限性牙周炎患者120例,按术后预防感染方式分为对照组和试验组,每组各60例。对照组口服罗红霉素胶囊,试验组局部涂用盐酸米诺环素软膏和甲硝唑凝胶。比较2组术后感染及并发症,采用牙周探针检查患者的改良龈沟出血指数（modified gingival creval bleeding index,mSBI）、牙周探诊深度(periodontal probing depth,PD)和改良菌斑指数（modified plaque index,mPLI）,应用免疫比浊法检测血清C-反应蛋白（C-reactive protein,CRP）水平,利用ELISA法检测肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平。采用SPSS 25.0软件包对数据进行统计学分析。结果：试验组愈合良好率91.67%,高于对照组的73.33%;术后感染率8.33%、并发症发生率6.67%,显著低于对照组的26.67%和20.00%（P<0.05）。治疗后试验组CRP、TNF-α和IL-6水平显著低于对照组（P<0.05）。修复后3、6个月,试验组mSBI、mPLI和PD显著低于对照组（P<0.05）。结论：局限性牙周炎种植牙患者局部涂用盐酸米诺环素和甲硝唑,可减轻口腔炎症反应,减少术后感染及其他并发症的发生,改善牙周健康。

关键词: 局限性牙周炎, 甲硝唑, 米诺环素, 感染, 炎症因子

Abstract: PURPOSE: To explore the value of metronidazole combined with minocycline in reducing infection after dental implant in patients with localized periodontitis. METHODS: A total of 120 patients with localized periodontitis who underwent dental implantation in the Department of Stomatological, Shanghai Pudong New Area People's Hospital from August 2021 to September 2022 were selected. According to the way of postoperative infection prevention, the patients were divided into control group and experimental group, with 60 patients in each group. The control group was orally given roxithromycin capsules, and the experimental group was locally coated with minocycline hydrochloride ointment and metronidazole gel. The incidence of postoperative infection and complications was compared between the two groups. The modified gingival creval bleeding index (mSBI), periodontal probing depth (PD) and modified plaque index (mPLI) of the patients were examined by periodontal probe. Serum C-reactive protein (CRP) level was determined by immunoturbidimetry and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) level was determined by ELISA. SPSS 25.0 software package was used for statistical analysis of the data. RESULTS: Good healing rate of the experimental group was 91.67% higher than that of the control group 73.33%, postoperative infection rate was 8.33% and complication rate was 6.67% in the experimental group, significantly lower than that of the control group (26.67% and 20.00%), respectively (P<0.05). After treatment, the level of CRP, TNF-α and IL-6 in the experimental group were significantly lower than those in the control group (P<0.05). At 3 and 6 months after treatment, mSBI, mPLI and PD in the experimental group were significantly lower than those in the control group(P<0.05). CONCLUSIONS: The administration of minocycline hydrochloride and metronidazole in patients with localized periodontitis undergoing implantation can reduce oral inflammatory response, reduce postoperative infection and other complications, and improve periodontal health.

Key words: Localized periodontitis, Metronidazole, Minocycline, Infection, Inflammatory factor

中图分类号:

R782.1

张世坤, 裴冬冬, 姜丹丹, 张丽华, 蔡建英, 常忠福. 甲硝唑联合米诺环素在局限性牙周炎种植牙术后感染中的应用效果评价[J]. 上海口腔医学, 2023, 32(5): 532-535.

ZHANG Shi-kun, PEI Dong-dong, JIANG Dan-dan, ZHANG Li-hua, CAI Jian-ying, CHANG Zhong-fu. Application of metronidazole combined with minocycline in reducing infection after dental implant in patients with localized periodontitis[J]. Shanghai Journal of Stomatology, 2023, 32(5): 532-535.

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甲硝唑联合米诺环素在局限性牙周炎种植牙术后感染中的应用效果评价

Application of metronidazole combined with minocycline in reducing infection after dental implant in patients with localized periodontitis

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