牙种植体周围炎相关因素和治疗新进展

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (6): 763-768.

• 综述 • 上一篇

牙种植体周围炎相关因素和治疗新进展

沈意涵¹, 邹多宏², 吴轶群¹

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔种植科, 上海市口腔医学重点实验室,上海 200011; 2.安徽医科大学口腔医学院,安徽医科大学附属口腔医院牙种植中心,安徽省口腔疾病研究中心实验室,安徽合肥 230032

收稿日期:2014-01-10 修回日期:2014-05-26 出版日期:2014-12-20 发布日期:2015-01-08
通讯作者: 吴轶群,Tel:021-23271699-5299,E-mail:yiqunwu@hotmail.com E-mail:linite@126.com
作者简介:沈意涵(1989-),男,硕士
基金资助:
国家自然科学基金（81371190）; 上海市自然科学基金（13ZR142400）; 上海交通大学医工交叉基金（YG2012MS32）

Research advances in peri-implantitis relevant factors and therapy

SHEN Yi-han, ZOU Duo-hong, WU Yi-qun

1.Department of Dental Implant, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Lab of Stomatology. Shanghai 200011;
2.The Dental Implant Center of Stomatological Hospital ﹠College, Anhui Medical University, Key Lab of Oral Diseases Research of Anhui Province. Hefei 230032, Anhui Province, China

Received:2014-01-10 Revised:2014-05-26 Online:2014-12-20 Published:2015-01-08
Supported by:
National Natural Science Foundation of China (81371190), Natural Science Foundation of Shanghai Municipality (13ZR142400) and Medical-Engineering Cross Found of Shanghai Jiao Tong University (YG2012MS32)

摘要/Abstract

摘要： [提要] 种植体周围炎指发生在已形成骨结合的种植体周围并引起支持牙槽骨丧失的一种炎症,已经成为引起种植义齿失败的主要原因之一。因此,种植体周围炎的相关危险因素和治疗方法受到学者们的高度关注。本文就种植体周围炎的相关危险因素及治疗方案的最新研究进展作一综述。

关键词: 种植体周围炎, 白介素, 牙周炎

Abstract: [Summary] Peri-implantitis has been defined as an inflammatory process affecting tissues around an osseo-integrated implant in function, and resulting in the loss of supportive alveolar bone. As it was one of the main causes which led to the failure of implant treatment, its risk factors and treatment were attracting more and more attention. This review summarized the progress of clinical research on peri-implantitis risk factors and treatments. [Key words] Peri-implantitis; Interleukin; Periodontitis

中图分类号:

R782.3

沈意涵, 邹多宏, 吴轶群. 牙种植体周围炎相关因素和治疗新进展[J]. 上海口腔医学, 2014, 23(6): 763-768.

SHEN Yi-han¹, ZOU Duo-hong², WU Yi-qun¹. Research advances in peri-implantitis relevant factors and therapy[J]. Shanghai Journal of Stomatology, 2014, 23(6): 763-768.

参考文献

[1] Mombelli A, Müller N, Cionca N. The epidemiology of peri-implantitis [J]. Clin Oral Implants Res, 2012, 23(Suppl 6): 67-76.
[2] Yoshie H, Kobayashi T, Tai H, et al. The role of genetic polymorphisms in periodontitis [J]. Periodontol 2000, 2007, 43: 102-132.
[3] Alexander MB, Damoulis PD. The role of cytokines in the pathogenesis of periodontal disease [J]. Curr Opin Periodontol, 1994, 1:39-53.
[4] Hamdy AA, Ebrahem MA. The effect of interleukin -1 allele 2 genotype (IL-1a (-889) and IL-1b (+3954)) on the individual's susceptibility to peri-implantitis: case control study [J]. J Oral Implantol, 2011, 37(3) : 325-334.
[5] Casado PL, Villas-Boas R, de Mello W, et al. Peri-implant disease and chronic periodontitis: is interleukin-6 gene promoter polymorphism the common risk factor in a Brazilian population? [J]. Int J Oral Maxillofac Implants, 2013, 28(1): 35-43.
[6] Melo RF, Lopes BM, Shibli JA, et al. Interleukin-1β and interleukin-6 expression and gene polymorphisms in subjects with peri-implant disease [J]. Clin Implant Dent Relat Res, 2012, 14(6): 905-914.
[7] Darabi E,Kadkhoda Z,Amirzargar A.Comparison of the levels of tumor necrosis factor-α and Interleukin-17 in gingival crevicular fluid of patients with peri-implantitis and a control group with healthy implants[J].Iran J Allergy Asthma Immunol,2013,12(1):75-80.
[8] Kadkhodazadeh M, Ebadian AR, Amid R, et al. Interleukin 17 receptor gene polymorphism in periimplantitis and chronic periodontitis [J]. Acta Med Iran, 2013, 51(6): 353-358.
[9] Luo Z, Wang H, Sun Z, et al. Expression of IL-22, IL-22R and IL-23 in the peri-implant soft tissues of patients with peri-implantitis [J]. Arch Oral Biol, 2013, 58(5): 523-529.
[10] No authors listed. Position paper: tobacco use and the periodontal patient. Research, Science and Therapy Committee of the American Academy of Periodontology[J]. J Periodontol,1999,70(11): 1419-1427.
[11] Agerbaek MR, Lang NP, Person GR. Comparisons of bacterial patterns present at implant and tooth sites in subjects on supportive periodontal therapy. I. Impact of clinical variables, gender and smoking[J]. Clin Oral Implamts Res,2006,17(1):18-24.
[12] Rinke S, Ohl S, Ziebolz D, et al. Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study[J]. Clin Oral Implants Res, 2011, 22(8): 826-833.
[13] 赵彦波, 南欣荣. 吸烟与种植体周围炎的相关性研究 [J]. 中国医药指南, 2012, 10(8): 27-29.
[14] 孟焕新. 牙周病学 [M]. 第3版. 北京: 人民卫生出版社, 2008: 299-301.
[15] Ong CT, Ivanovski S, Needleman IG, et al. Systematic review of implant outcomes in treated periodontitis subjects [J]. J Clin Periodontol, 2008, 35(5): 438-462.
[16] Fürst MM, Salvi GE, Lang NP, et al. Bacterial colonization immediately after installation on oral titanium implants [J]. Clin Oral Implants Res, 2007, 18(4): 501-508.
[17] Kocar M, Seme K, Hren NI. Characterization of the normal bacterial flora in peri-implant sulci of partially and completely edentulous patients[J]. Int J Oral Maxillofac Implants,2010, 25(4): 690-698.
[18] Salvi GE, Aglietta M, Eick S, et al. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans [J]. Clin Oral Implants Res, 2012, 23(2): 182-190.
[19] Heuer W, Kettenring A, Stumpp SN, et al. Metagenomic analysis of the peri-implant and periodontal microflora in patients with clinical signs of gingivitis or mucositis [J]. Clin Oral Investig, 2012, 16(3): 843-850.
[20] Lang NP, Bosshardt DD, Lulic M. Do mucositis lesions around implants differ from gingivitis lesions around teeth? [J]. J Clin Periodontol, 2011, 38(Suppl 11): 182-187.
[21] Berglundh T, Zitzmann NU, Donati M. Are peri-implantitis lesions different from periodontitis lesions? [J]. J Clin Periodontol, 2011, 38(Suppl 11): 188-202.
[22] Venza I, Visalli M, Cucinotta M, et al. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes [J]. J Periodontol, 2010, 81(1): 99-108.
[23] Dvorak G, Arnhart C, Heuberer S, et al. Peri-implantitis and late implant failures in postmenopausal women: a cross-sectional study [J]. J Clin Periodontol, 2011, 38(10): 950-955.
[24] Renvert S, Aghazadeh A, Hallström H, et al. Factors related to peri-implantitis-a retrospective study [J]. Clin Oral Implants Res, 2014, 25(4): 522-529 .
[25] Renvert S, Samuelsson E, Lindahl C, et al. Mechanical non-surgical treatment of peri-implantitis: a double-blind randomized longitudinal clinical study. I: clinical results[J]. J Clin Periodontol, 2009, 36(7): 604-609.
[26] 周鑫才, 刘得玺, 石琦, 等. 种植体周围炎非手术治疗的临床疗效分析 [J].临床口腔医学杂志, 2011, 27(12): 727-728.
[27] Renvert S, Lessem J, Dahlén G ,et al. Mechanical and repeated antimicrobial therapy using a local drug delivery system in the treatment of peri-implantitis: a randomized clinical trial [J]. J Periodontol, 2008, 79(5): 836-844.
[28] de Waal YC, Raghoebar GM, Huddleston Slater JJ, et al. Implant decontamination during surgical peri-implantitis treatment: a randomized, double-blind, placebo-controlled trial[J]. J Clin Periodontol, 2013, 40(2): 186-195.
[29] Bassetti M, Schär D, Wicki B, et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial [J]. Clin Oral Implants Res, 2014, 25(3): 279-287.
[30] Mombelli A, Feloutzis A, Brägger U, et al. Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results [J]. Clin Oral Implants Res, 2001, 12(4): 287-294 .
[31] Badran Z, Bories C, Struillou X, et al. Er:YAG laser in the clinical management of severe peri-implantitis: a case report [J]. J Oral Implantol, 2011, 37(1): 212-217.
[32] Yamamoto A, Tanabe T. Treatment of peri-implantitis around TiUnite-surface implants using Er:YAG laser microexplosions [J]. Int J Periodontics Restorative Dent, 2013, 33(1): 21-30.
[33] Schär D, Ramseier CA, Eick S, et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: six-month outcomes of a prospective randomized clinical trial [J]. Clin Oral Implants Res, 2013, 24(1): 104-110.
[34] Persson GR, Roos-Jansåker AM, Lindahl C, et al. Microbiologic results after non-surgical erbium-doped: Yttrium, aluminum, and garnet laser or air-abrasive treatment of peri-implantitis: a randomized clinical trial[J]. J Periodontol,2011,82(9):1267-1278.
[35] Thierbach R, Eger T. Clinical outcome of a nonsurgical and surgical treatment protocol in different types of peri-implantitis: a case series [J]. Quintessence Int, 2013, 44(2): 137-148.
[36] Renvert S, Polyzois I, Claffey N. Surgical therapy for the control of peri-implantitis[J]. Clin Oral Implants Res,2012,23(Suppl 6): 84-94.
[37] Schwarz F, Sahm N, Becker J. Combined surgical therapy of advanced peri-implantitis lesions with concomitant soft tissue volume augmentation. A case series [J]. Clin Oral Implants Res, 2014, 25(1): 132-136.
[38] Matarasso S, Iorio Siciliano V, Aglietta M, et al. Clinical and radiographic outcomes of a combined resective and regenerative approach in the treatment of peri-implantitis: a prospective case series [J]. Clin Oral Implants Res, 2013 May 8.[Epub ahead of print]
[39] Lorenz B, Kang T. Treating peri-implantitis using a combined regenerative/resective procedure: a case report [J]. Compend Contin Educ Dent, 2013, 34(4): e57-61.
[40] Roos-Jansåker AM, Lindahl C, Persson GR, et al. Long-term stability of surgical bone regenerative procedures of peri-implantitis lesions in a prospective case-control study over 3 years [J]. J Clin Periodontol, 2011, 38(6): 590-597.
[41] Faggion CM Jr, Chambrone L, Listl S, et al. Network meta-analysis for evaluating interventions in implant dentistry: the case of peri-implantitis treatment [J]. Clin Implant Dent Relat Res, 2013, 15(4): 576-588.
[42] Serino G, Turri A. Outcome of surgical treatment of peri-implantitis: results from a 2-year prospective clinical study in humans [J]. Clin Oral Implants Res, 2011, 22(11): 1214-1220
[43] Schwarz F, John G, Mainusch S, et al. Combined surgical therapy of peri-implantitis evaluating two methods of surface debridement and decontamination. A two-year clinical follow up report [J]. J Clin Periodontol, 2012, 39(8): 789-797.
[44] Albouy J-P, Abrahamsson I, Persson LG, et al. Implant surface characteristics influence the outcome of treatment of peri-implantitis: an experimental study in dogs [J]. J Clin Periodontol, 2011, 38(1): 58-64.
[45] Gómez-Florit M, Xing R, Ramis JM, et al. Human gingival fibroblasts function is stimulated on machined hydrided titanium zirconium dental implants [J]. J Dent, 2014, 42(1): 30-38.

牙种植体周围炎相关因素和治疗新进展

Research advances in peri-implantitis relevant factors and therapy

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