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Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1β and IL-17F in patients with early peri-implant soft tissue inflammation
LI Yu-leng, WANG Wei-zhong, GONG Zhong-cheng
2019, 28 (5):
494-498.
doi: 10.19439/j.sjos.2019.05.009
PURPOSE: To study the effect of dimethylamine tetracycline combined with tea polyphenols on the levels of interleukin-1 β (IL-1β) and interleukin-17F (IL-17F) in patients with early peri-implant soft tissue inflammation. METHODS: Ninety-six patients with early peri-implant soft tissue inflammation were selected from May 2016 to May 2018. They were randomly divided into dimethylamine tetracycline group and combination group, 48 cases in each group. Patients in the dimethylamine tetracycline group were treated with dimethylamine tetracycline hydrochloride ointment, while patients in the combined group were treated with tea polyphenols on the basis of dimethylamine tetracycline group. Plaque index (PLI), sulcus bleeding index (SBI), attachment loss (AL), gingival crevicular fluid (GCF), probing depth (PD), IL-1β and IL-17F levels were detected. The data were analyzed using SPSS 20.0 software package. RESULTS: After treatment, PLI, SBI, AL, GCF and PD in both groups were significantly lower than those before treatment (P<0.05). The levels of PLI, SBI, AL, GCF and PD in the combined group were significantly lower than those in the dimethylamine tetracycline group after treatment (P<0.05). After treatment, the levels of IL-1beta and IL-17F in both groups were significantly lower than those before treatment (P<0.05). After treatment, the levels of IL-1β and IL-17F in the combined group were significantly lower than those in the dimethylamine tetracycline group (P<0.05). The effective rate of combined group was 93.75%, which was significantly higher than that of dimethylamine tetracycline group (77.08%, P<0.05). The adverse reaction rate of the combined group was 6.25% ,significantly lower than that of the dimethylamine tetracycline group (20.83%, P<0.05). CONCLUSIONS: Dimethylamine tetracycline combined with tea polyphenols in the treatment of early peri-implant soft tissue inflammation has significant effect. It can improve the clinical symptoms of patients, reduce the levels of IL-1β and IL-17F, and decrease the occurrence of adverse effects.
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