Abstract: PURPOSE: To study the correlation between the levels of inflammatory factors in gingival crevicular fluid and implant stability and prognosis after oral implant restoration. METHODS: A total of 78 patients who underwent oral implant restoration surgery from August 2022 to August 2023 were selected as the experimental group. According to the results of X-ray examination 1 month after implantation, the patients were divided into poor prognosis subgroup(n=33) and good prognosis subgroup(n=45), another 60 healthy subjects who underwent physical examination during the same period were selected as the control group. The gingival crevicular fluid of all research subjects was collected, and chemiluminescent immunoassay was used to determine high-sensitivity C-reactive protein (hsCRP), and enzyme-linked immunosorbent assay was used to determine amyloid A(SAA) and procalcitonin (PCT), implant stability quotient(ISQ) was recorded after surgery. Pearson's correlation analysis was used to evaluate the correlation between inflammatory factors in gingival crevicular fluid and ISQ, and multifactor logistic regression analysis was used to analyze the relationship between inflammatory factors in gingival crevicular fluid and implant prognosis. Statistical analysis was performed with SPSS 22.0 software package. RESULTS: The levels of hsCRP, SAA and PCT in the gingival crevicular fluid of the experimental group were significantly higher than the control group(P<0.05), the levels of hsCRP, SAA and PCT in the gingival crevicular fluid of the poor prognosis subgroup were significantly higher than the good prognosis subgroup (P<0.05). The initial and second-stage ISQ values of the patients in the experimental group were (74.08±6.12) and (76.78±5.11) respectively. Pearson's correlation analysis results showed that the gingival crevicular fluid hsCRP, SAA and PCT were significantly negatively correlated with initial and second-stage ISQ(P<0.05); multi-factor logistic regression analysis results showed that hsCRP, SAA and PCT in gingival crevicular fluid were important factors affecting the prognosis of patients with dental implants(P<0.05). CONCLUSIONS: The levels of hsCRP, SAA and PCT in the gingival crevicular fluid after oral implant restoration are significantly increased, which are related to the stability and prognosis of the implant.

Key words: Oral implant restoration, Gingival crevicular fluid, Inflammatory factors, Implant stability, Prognosis, Correlation