Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis

doi:10.19439/j.sjos.2024.05.007

Abstract

Abstract: PURPOSE: To explore the association between tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) gene polymorphism and susceptibility to diabetic periodontitis. METHODS: A total of 150 patients with type 2 diabetes were selected from September 2022 to September 2023. The patients were divided into combined group(n=50), non-combined group (n=50) and control group (n=50) according to whether they had periodontitis. Clinical medical records of all subjects were collected, TRAIL G1525A and C1595T gene polymorphisms were detected, and the influencing factors of type 2 diabetic periodontitis were analyzed. Statistical analysis was performed with SPSS 19.0 software package. RESULTS: In combined and non-combined group, the fasting blood glucose(FBG), loss of attachment(AL), gingival crevicular bleeding index (SBI) and blood calcium were significantly lower than those in the control group, and HbA1c and serum alkaline phosphatase(ALP) were significantly higher than those in the control group(P<0.05). The GG gene frequency of TRAIL G1525A gene in the combined group was significantly higher than that in the non-combined group and control group(P<0.05). There was no significant difference in genotype distribution of TRAIL C1595T among three groups(P>0.05).HbA1c, AL, SBI, ALP and TRAIL G1525A polymorphisms were risk factors for periodontitis(P<0.05). The distribution of TRAIL G1525ALeuGGin with moderate and severe periodontitis was significantly different from that with mild periodontitis (P<0.05). CONCLUSIONS: TRAIL G1525A gene is associated with the susceptibility of diabetic periodontitis, and GG genotype patients with type 2 diabetes have a higher risk of periodontitis.

Key words: Type 2 diabetes mellitus, Periodontitis, Tumor necrosis factor-associated apoptosis-inducing ligand

CLC Number:

R780.2

CHEN Li, ZHANG Zhong-yue, ZHANG Shu-hua, YAN Na. Association of tumor necrosis factor related apoptosis inducing ligand (TRAIL) gene polymorphism with susceptibility to diabetes periodontitis[J]. Shanghai Journal of Stomatology, 2024, 33(5): 481-485.

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