Application and evaluation of n-HA/ chitosan/minocycline composite scaffold in the model of peri-implant inflammatory bone defect

doi:10.19439/j.sjos.2024.05.001

Abstract

Abstract: PURPOSE: To analyze the effect of n-HA/chitosan/minocycline composite scaffold in the animal model of peri-implant inflammatory bone defect. METHODS: Twelve healthy adult male beagle dogs were selected to construct the model of peri-implant inflammatory bone defect. The control group(n=6) underwent bone regeneration by alveolar self-healing without any treatment in the bone defect area. In the experimental group(n=6), n-HA/chitosan/minocycline composite scaffold prepared was implanted into the bone defect site. Periodontitis, bone defect, pathological parameters, bone mineral density(BMD) and new bone formation rate were recorded in two groups of animal models. Statistical analysis was performed with SPSS 26.0 software package. RESULTS: There was no significant difference in the horizontal width and vertical depth of bone defect between the control group and the experimental group before treatment (P>0.05). At 4, 8 and 12 weeks after treatment, the horizontal width and vertical depth of the experimental group were significantly lower than those before treatment and the control group(P<0.05). There was no significant difference in probing depth(PD), sulcus bleeding index(SBI) and plaque index(PLI) between the control group and the experimental group before treatment(P>0.05). PD, SBI and PLI in the experimental group were significantly higher than those before treatment and in the control group at 4, 8 and 12 weeks after treatment(P<0.05). BMD value, new bone height and new bone formation rate of the experimental group were significantly higher than those of the control group at 4, 8 and 12 weeks after treatment(P<0.05). CONCLUSIONS: n-HA/chitosan/minocycline composite scaffold shows a good effect in the model of peri-implant inflammatory bone defect, which can promote bone osteointegration and bone regeneration in the peri-implant bone defect area.

Key words: Perimplantitis, Bone defect, Minocycline, Nano-hydroxyapatite, Chitosan

CLC Number:

R782.1

NIU Wan-qiong, WANG Zhen-hua, ZHOU Zhi-wei. Application and evaluation of n-HA/ chitosan/minocycline composite scaffold in the model of peri-implant inflammatory bone defect[J]. Shanghai Journal of Stomatology, 2024, 33(5): 449-454.

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