Comparative analysis of the effect of autologous dentin particles, implantation of Bio-Oss on guided bone regeneration in the treatment of periodontal bone defects

doi:10.19439/j.sjos.2022.05.015

Abstract

Abstract: PURPOSE: To analyze the effect of autologous dentin particles and Bio-Oss bone powder implantation on guided bone regeneration in the treatment of periodontal bone defects. METHODS: Eighty-two patients with periodontal bone defect treated in Zhangye People's Hospital from May 2018 to May 2020 who underwent guided bone regeneration treatment were selected and divided into experimental group and control group according to random number table method, with 41 cases in each group. The control group was implanted with Bio-Oss during the operation, and the experimental group was implanted with autologous dentin particles during operation. Periodontal pocket depth and attachment loss, buccal soft tissue profile, buccal soft tissue thickness, red aesthetic score, success rate, and complications were compared between the two groups of patients. SPSS 22.0 software package was used for statistical analysis. RESULTS: Comparison within the group showed that 1 month and 1 year after operation, the periodontal pocket depth and attachment loss of the two groups were significantly reduced(P<0.05); and 1 year after operation, the periodontal pocket depth and attachment loss of the two groups were significantly lower than 1 month after surgery(P<0.05). Comparison between groups showed that 1 month and 1 year after operation, the periodontal pocket depth and attachment loss of the experimental group were significantly lower than those of the control group (P<0.05). Comparison within groups showed that 1 month and 1 year after operation, the buccal soft tissue profile of the two groups were significantly higher than that before operation (P<0.05); and 1 year after operation, the buccal soft tissue profile of the two groups were significantly lower than 1 month after operation. Comparison between groups showed that 1 year after operation, the buccal soft tissue profile of the experimental group was significantly higher than that of the control group (P<0.05). Comparison within groups showed that 1 month and 1 year after surgery, the thickness of the buccal soft tissue of the two groups were significantly higher than that before surgery. Comparison between groups showed that there was no significant difference in the thickness of the buccal soft tissue at each time point between the two groups(P>0.05). Comparison within groups showed that 1 month and 1 year after operation, the red aesthetic scores of patients in the two groups were significantly higher than those before operation (P<0.05); in addition, the red aesthetic scores of the two groups 1 year after surgery were significantly higher than those 1 month after surgery (P<0.05). Comparison between groups showed that 1 month and 1 year after surgery, the red aesthetic scores of the experimental group were significantly higher than those of the control group (P<0.05). One year after operation, the success rate of the experimental group and the control group were 90.24% (37/41) and 85.37% (35/41), respectively, and there was no significant difference between the two groups(P>0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05). CONCLUSIONS: Autologous dentin particles can be used to guide bone regeneration to treat patients with periodontal bone defects, which can reduce the depth of periodontal pockets and loss of attachment, improve the buccal soft tissue profile and red aesthetic score, and the success rate is equivalent to implantation of Bio-Oss. Therefore, it is a safe and reliable treatment method.

Key words: Autologous dentin particles, Bio-Oss bone meal implantation, Guided bone regeneration, Periodontal bone defect

CLC Number:

R781.4

MAO Xin-xia, LIN Xiao-wei, WEI Xuan, LI Qin. Comparative analysis of the effect of autologous dentin particles, implantation of Bio-Oss on guided bone regeneration in the treatment of periodontal bone defects[J]. Shanghai Journal of Stomatology, 2022, 31(5): 530-534.

References

[1] Tan J, Zhang M, Hai Z, et al.Sustained release of two bioactive factors from supramolecular hydrogel promotes periodontal bone regeneration[J]. ACS Nano, 2019, 13(5): 5616-5622.
[2] Sheikh Z, Qureshi J, Alshahrani AM, et al.Collagen based barrier membranes for periodontal guided bone regeneration applications[J]. Odontology, 2017, 105(1): 1-12.
[3] Nibali L, Sultan D, Arena C, et al.Periodontal infrabony defects: systematic review of healing by defect morphology following regenerative surgery[J]. J Clin Periodontol, 2021, 48(1): 100-113.
[4] Zhuang G, Mao J, Yang G, et al.Influence of different incision designs on bone increment of guided bone regeneration (Bio-Gide collagen membrane +Bio-Oss bone powder) during the same period of maxillary anterior tooth implantation[J]. Bioengineered, 2021, 12(1): 2155-2163.
[5] Andrade C, Camino J, Nally M, et al.Combining autologous particulate dentin, L-PRF, and fibrinogen to create a matrix for predictable ridge preservation: a pilot clinical study[J]. Clin Oral Investig, 2020, 24(3): 1151-1160.
[6] 刘洪臣. 美容牙科学[M]. 北京:人民卫生出版社, 2012:96-97.
[7] 万鹏, 董潇潇. 牙齿与种植体软组织美学处理[M]. 沈阳: 辽宁科学技术出版社, 2014:102-103.
[8] 王晓玲. 口腔材料学[M]. 郑州: 郑州大学出版社, 2012: 124-125.
[9] Dewi AH, Ana ID.The use of hydroxyapatite bone substitute grafting for alveolar ridge preservation, sinus augmentation, and periodontal bone defect: a systematic review[J]. Heliyon, 2018, 4(10): 884-892.
[10] Urban IA, Monje A.Guided bone regeneration in alveolar bone reconstruction[J]. Oral Maxillofac Surg Clin North Am, 2019, 31(2): 331-338.
[11] Zhang C, Zhang H, Yue Z, et al.Modified minimally invasive surgical technique plus Bio-Oss collagen for regenerative therapy of isolated interdental intrabony defects: study protocol for a randomised controlled trial[J]. BMJ Open, 2020, 10(12): e040046.
[12] De Biase A, Mazzucchi G, Di Nardo D, et al.Prevention of periodontal pocket formation after mandibular third molar extraction using dentin autologous graft: a split mouth case report[J]. Case Rep Dent, 2020: 1762862.
[13] Bernardi S, Macchiarelli G, Bianchi S.Autologous materials in regenerative dentistry: harvested bone, platelet concentrates and dentin derivates[J]. Molecules, 2020, 25(22): 5330-5338.
[14] Valdec S, Pasic P, Soltermann A, et al.Alveolar ridge preservation with autologous particulated dentin - a case series[J]. Int J Implant Dent, 2017, 3(1): 12-18.
[15] Wessing B, Lettner S, Zechner W.Guided bone regeneration with collagen membranes and particulate graft materials: a systematic review and meta-analysis[J]. Int J Oral Maxillofac Implants, 2018, 33(1): 87-100.
[16] Lotz M, Starz F, Kuster I, et al.Lateral ridge augmentation with autologous dentin from the wisdom tooth - a case report[J]. Swiss Dent J, 2021, 131(5):425-430.