Abstract: PURPOSE: To evaluate effects of oral implant prosthesis in patients with missing teeth and influence on gingival sulcus TNF-α, IL-6 and IL-8. METHODS: Ninety four cases with tooth missing from October 2014 to October 2016 were divided into 2 groups, with 47 in each group. Patients in the control group were treated with conventional restoration, experimental group were treated with oral implantation. The clinical effects, levels of TNF-α, IL-6 and IL-8, gingival state, dental functions, and complications between the two groups were compared. Statistical analysis was performed using SPSS8.0 software package. RESULTS: The total effective rate of the experimental group was significantly higher than the control group (95.74% vs 80.85%, P<0.05). TNF-α, IL-6 and IL-8 of the experimental group was significantly lower than the control group (3.55±0.42) μg/L, (25.90±3.24) μg/L, (69.34±8.65) μg/L vs (4.69±0.58) μg/L, (41.37±5.19) μg/L, (108.72±13.56) μg/L (P<0.05). The gingival state, dental functions of the experimental group were significantly better than the control group, and the complications was significantly less than the control group (P<0.05). CONCLUSIONS: The application of oral implant in dentition missing patients is satisfactory, which can inhibit the expression of TNF-α, IL-6 and IL-8, reduce local inflammatory response and improve dental function.

Key words: Tooth missing, Oral implant prosthesis, Tumor necrosis factor-α, Interleukin 6, Interleukin 8