The mechanism of corticotomy accelerating orthodontic tooth movement in SD rats

doi:10.19439/j.sjos.2017.01.003

Abstract

Abstract: PURPOSE: To study the influences of corticotomy on orthodontic tooth movement (OTM) and the underlying mechanism in rats. METHODS: Forty-eight female Sprague-Dawley rats were randomly assigned to corticotomy group (Cort, 24 rats) or sham-corticotomy group (Sham, 24 rats). All rats were subjected OTM after corticotomy or sham surgery. 6 rats of each group were sacrificed at 0, 1, 3 and 7 day of OTM. OTM were measured with an electronic digital caliper. Osteoclasts were counted in pressure side with TRAP. RANKL were measure by IHC at pressure side. The data were analyzed with SPSS 16.0 software package. RESULTS: OTM at the 1 and 7 day in Cort group increased compared with sham group. Number of TRAP positive osteoclasts in pressure side increased in Cort group at the 3 and 7 day. Expression of RANKL in pressure side also increased in Cort group at the 3 and 7 day. CONCLUSIONS: Corticotomy accelerates OTM in rats and it may result from promoted bone resorption via increased RANKL expression in periodontal tissue.

Key words: Corticotomy, Orthodontic tooth movement, Osteoclast, RANKL

CLC Number:

R783.5

ZHU Shao-yue, YUAN Chang-yong, LIU Zong-xiang, LI Xiao-ming, WANG Peng-lai. The mechanism of corticotomy accelerating orthodontic tooth movement in SD rats[J]. Shanghai Journal of Stomatology, 2017, 26(1): 12-16.

References

[1] 朱琳琳, 李明. 骨皮质切开辅助正畸研究进展 [J]. 口腔医学, 2015, 35(2): 147-149, 152.
[2] Yuan H, Zhu X, Lu J, et al. Accelerated orthodontic tooth movement following Le Fort I osteotomy in a rodent model [J]. J Oral Maxillofac Surg, 2014, 72(4): 764-772.
[3] Ong MM, Wang HL. Periodontic and orthodontic treatment in adults[J]. Am J Orthod Dentofacial Orthop, 2002, 122(4): 420-428.
[4] Wilcko WM, Wilcko T, Bouquot JE, et al. Rapid orthodontics with alveolar reshaping: two case reports of decrowding [J]. Int J Periodontics Restorative Dent, 2001, 21(1): 9-19.
[5] Wilcko MT, Wilcko WM, Pulver JJ, et al. Accelerated osteogenic orthodontics technique: a 1-stage surgically facilitated rapid orthodontic technique with alveolar augmentation[J]. J Oral Maxillofac Surg, 2009, 67(10): 2149-2159.
[6] Patterson BM, Dalci O, Darendeliler MA, et al. Corticotomies and orthodontic tooth movement: a systematic review[J]. J Oral Maxillofac Surg, 2016, 74(3): 453-473.
[7] Hoogeveen EJ, Jansma J, Ren Y. Surgically facilitated orthodontic treatment: a systematic review[J]. Am J Orthod Dentofacial Orthop, 2014, 145(4 Suppl): S51-64.
[8] Kim B, Dreyer CW, Sampson W. Accelerating orthodontic tooth movement with the aid of periodontal surgery the practitioner viewpoint [J]. Aust Orthod J, 2014, 30(2): 201-207.
[9] Iglesias-Linares A, Yanez-Vico RM, Moreno-Fernandez AM, et al. Corticotomy-assisted orthodontic enhancement by bone morphogenetic protein-2 administration[J]. J Oral Maxillofac Surg, 2012, 70(2): e124-132.
[10] Andrade I Jr, Sousa AB, da Silva GG. New therapeutic modalities to modulate orthodontic tooth movement[J]. Dental Press J Orthod, 2014, 19(6): 123-133.
[11] Kalemaj Z, Debernardl CL, Buti J. Efficacy of surgical and non-surgical interventions on accelerating orthodontic tooth movement: a systematic review [J]. Eur J Oral Implantol, 2015, 8(1): 9-24.
[12] Abbas NH, Sabet NE, Hassan IT. Evaluation of corticotomy-facilitated orthodontics and piezocision in rapid canine retraction[J]. Am J Orthod Dentofacial Orthop, 2016, 149(4): 473-480.
[13] Cao L, Sun J. Bone contribution in corticotomy-assisted rapid maxillary expansion[J]. Am J Orthod Dentofacial Orthop, 2016, 149(1): 6-7.
[14] Meikle MC. The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt [J]. Eur J Orthod, 2005, 28(3): 221-240.
[15] Sebaoun JD, Ferguson DJ, Wilcko MT, et al. Alveolar osteotomy and rapid orthodontic treatments [J]. Orthod Fr, 2007, 78(3): 217-225.
[16] Smith RJ, Burstone CJ. Mechanics of tooth movement [J]. Am J Orthod, 1984, 85(4): 294-307.
[17] Persson M. A 100th anniversary: Sandstedt's experiments on tissue changes during tooth movement [J]. J Orthod, 2005, 32(1): 27-28.
[18] 刘继中, 纪宗玲, 陈苏民. OPG/RANKL/RANK系统与骨破坏性疾病 [J]. 生物工程学报, 2003, 19(6): 655-660.
[19] Kurohama T, Hotokezaka H, Hashimoto M, et al. Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats [J]. Eur J Orthod, 2016 May 3. [Epub ahead of print]
[20] Yaffe A, Fine N, Binderman I. Regional accelerated phenomenon in the mandible following mucoperiosteal flap surgery[J]. J Periodontol, 1994, 65(1): 79-83.
[21] Boyce BF, Xing L. The RANKL/RANK/OPG pathway[J]. Curr Osteoporos Rep, 2007, 5(3): 98-104.
[22] Wu Y, Zhang P, Dai Q, et al. Osteoclastogenesis accompanying early osteoblastic differentiation of BMSCs promoted by mechanical stretch [J]. Biomed Rep, 2013, 1(3): 474-478.