Shanghai Journal of Stomatology

Shanghai Journal of Stomatology ›› 2017, Vol. 26 ›› Issue (5): 465-470.doi: 10.19439/j.sjos.2017.05.001

• Orginal Article • Previous Articles     Next Articles

Effect of icraiin on turnover of alveolar bone during orthodontic tooth movement in rats

YANG Pan-pan1, 2, WANG Xu-xia2, 3, CHEN Yun4, WANG Qian-qian1, 2, WANG Ying-zi1, 2, ZHANG Jun1, 2   

  1. 1.Department of Orthodontics,School of Stomatology, Shandong University. Jinan 250012, Shandong Province;
    2.Shandong Provincial Key Laboratory of Oral Biomedicine. Jinan 250012, Shandong Province;
    3.Department of Oral and Maxillofacial Surgery, School of Stomatology, Shandong University. Jinan 250012, Shandong Province;
    4.Department of Pediatric, College of Stomatology, Nanjing Medical University. Nanjing 210029, Jiangsu Province, China
  • Received:2017-03-30 Revised:2017-05-04 Online:2017-10-25 Published:2017-11-23

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Abstract: PURPOSE: To observe the effect of icariin on turnover of paradentium as well as the mechanism of effects on osteoclast during orthodontic tooth movement in rats. METHODS: Forty-right SD rats were used to establish animal models of OTM and divided into two groups randomly: the control group and the experimental group. Rats in the experimental group were given 20 mg/（kg·d） icariin by intragastric administration, while rats in the control group received solvent with the same volume. The rats were sacrificed in batch on the 7th, 14th, 21st and 28th day after orthodontic treatment. The amount of tooth movement was measured, and histomorphometric analysis based on slices from periodontium adjacent to the maxillary first molars was used to observe new bone formation, bone resorption and quantify osteoclasts. Statistical analysis was performed by using SPSS 16.0 software package. RESULTS: The movement distance of the first molar was significantly larger in the icariin group than that in the control group (P<0.05). In the icariin group, the number of osteoclasts was significantly higher than the control group at the 7th day and then demonstrated a steady decrease. CONCLUSIONS: Icariin could accelerate OTM in rats through promoting bone turnover of alveolar bone.

Key words: Icariin, Osteoclast, Orthodontic tooth movement, Bone turnover

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