Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma

Shanghai Journal of Stomatology ›› 2013, Vol. 22 ›› Issue (6): 667-670.

• Clinical Study • Previous Articles Next Articles

Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma

QI Zhong-zheng¹, LIU Jie², LIU Fa-yu¹, SUN Chang-fu¹

1.Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University. Shenyang 110002; 2.Department of Central Laboratory, China Medical University. Shenyang 110001, Liaoning Province, China

Received:2013-07-04 Revised:2013-08-22 Online:2013-04-12 Published:2013-04-12
Supported by:
Supported by National Natural Science Foundation of China(81102058).

Abstract

Abstract: PURPOSE: To study the effect of pituitary tumour transforming gene (PTTG) on invasion and metastasis of salivary adenoid cystic carcinoma. METHODS: The expression of PTTG and bFGF was investigated in 40 salivary adenoid cystic carcinoma tissues and 20 normal salivary tissues by immunohistochemistry. Pearson’s Chi-square test and Spearman correlation analysis were used to analyze the data using SPSS 11.5 software package. RESULTS: The expression of PTTG and bFGF were significantly higher in salivary adenoid cystic carcinoma tissues than in normal salivary gland tissues(P<0.01)and their expression levels were positively correlated(P<0.01). CONCLUSIONS: PTTG and bFGF are highly expressed in salivary adenoid cystic carcinoma. The invasion and metastasis of salivary adenoid cystic carcinoma are correlated with the expression of PTTG.

Key words: Pituitary tumor transforming gene, Salivary adenoid cystic carcinoma, Immunohistochemistry

CLC Number:

R739.87

QI Zhong-zheng, LIU Jie, LIU Fa-yu, SUN Chang-fu. Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma[J]. Shanghai Journal of Stomatology, 2013, 22(6): 667-670.

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Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma

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