Shanghai Journal of Stomatology

Shanghai Journal of Stomatology ›› 2013, Vol. 22 ›› Issue (6): 671-675.

• Clinical Study • Previous Articles     Next Articles

Assessment of mental health status in oral squamous cell carcinoma patients and its correlation with catecholamines level

LI Bo1,2, LI Li3, GUO Dai-mo1, PAN Wei-yi1, DUAN Ze-xi1, HUANG Yi-bing1, ZOU Xiao-li3, ZHU Cai-rong3, XIE Hui-xu1,2   

  1. 1.West China School of Stomatology, Sichuan University. Chengdu 610041; 2.State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University. Chengdu 610041; 3.Department of Medical Management, West China Second University Hospital, Sichuan University. Chengdu 610041; 4.West China School of Public Health, Sichuan University. Chengdu 610041, Sichuan Province, China
  • Received:2013-05-05 Revised:2013-07-12 Online:2013-04-12 Published:2013-04-12
  • Supported by:
    Supported by National Natural Science Foundation of China (81172578) and Natural University Students Innovation Training Program (201210610096).

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Abstract: PURPOSE: To investigate the relationship between mental health status and catecholamines level in oral squamous cell carcinoma patients. METHODS: Forty patients with oral squamous carcinoma (OSCC) who were diagnosed in West China School of Stomatology between Dec. 2011 and Aug. 2012, were assessed with symptom checklist-90 (the 5-grade scoring of 0 to 4 points was used) independently according to their actual conditions. Blood sample was taken on the second admission day and fresh tumor tissue with the weight of 0.5 g was obtained. A method was developed for determination of catecholamine and glucocorticoid in serum using liquid chromatography-tandem mass spectrometry (HPLC-MS-MS). SPSS19.0 software package was used for statistical analysis. RESULTS: Forty patients were included in the study. Compared with the scores of SCL-90 in national norms, the scores were all higher in oral squamous carcinoma patients except the interpersonal relationship. Epinephrine(E) and norepinephrine(NE) in serum was (70.27±34.50) pg/mL and (316.73±109.22) pg/mL, respectively. E and NE in tumor tissues was (6.66±3.58) pg/mg and (12.67±5.27) pg/mg respectively. As the concentrations of NE and E from circulating serum increasing, the stage and grade of oral squamous carcinoma were promoted. CONCLUSIONS: Psychiatric factors have an important impact on OSCC patients. The increased level of catecholamines is closely related to clinical stage and grade of OSCC.

Key words: Symptom checklist-90, Oral squamous carcinoma, Liquid chromatography, Mass spectrometry；Catecholamines

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