Effect of serum ICAM-1 and MMP-8 levels in patients with dentition loss on prognosis after dental implant restoration

doi:10.19439/j.sjos.2026.02.015

Abstract

Abstract: PURPOSE: To investigate the serum levels of intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-8 (MMP-8) in patients with tooth loss and their relationship with the effectiveness of oral implant restoration. METHODS: A total of 80 patients with dentition loss who underwent dental implant restoration in Mianyang People's Hospital from January 2021 to January 2023 were recorded as the experimental group, and were divided into good prognosis group (n=53) and poor prognosis group (n=27) according to their prognosis, while 74 healthy volunteers who underwent physical examination during the same period were selected as the control group. The serum levels of high-sensitivity C-reactive protein(hs-CRP), tumor necrosis factor-α (TNF-α), ICAM-1 and MMP-8 were detected by ELISA. Pearson correlation analysis was used to analyze the correlation between ICAM-1 and MMP-8 levels in patients with poor prognosis. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of ICAM-1 and MMP-8 levels in patients with poor prognosis, and Z test was used to compare the differences in the area under the curve (AUC). Results: The serum levels of hs-CRP, TNF-α, ICAM-1 and MMP-8 in the experimental group were significantly higher than those in the control group, and the poor prognosis group was significantly higher than that in the good prognosis group (P<0.05). The high expression of ICAM-1 and MMP-8 was an independent risk factor for poor prognosis in patients (P<0.05). The serum levels of ICAM-1 and MMP-8 in the poor prognosis group were positively correlated(r=0.433, P=0.000). The AUC for poor prognosis in patients diagnosed with serum ICAM-1 and MMP-8 alone was 0.776 and 0.762, respectively. The AUC of the combined diagnosis of serum ICAM-1 and MMP-8 was 0.908, which was better than serum ICAM-1 and MMP-8 alone (P<0.05). CONCLUSIONS: The levels of ICAM-1 and MMP-8 are elevated in patients with tooth loss, and the levels are higher in patients with poor prognosis. There is a positive correlation between the two indexes, and they may jointly participate in the mechanism of poor prognosis. The combination of the two indexes has a higher value in the diagnosis of poor prognosis, which can provide a reference for clinical prognosis evaluation.

Key words: Tooth loss, ICAM-1, MMP-8, Oral implant restoration, Prognosis

CLC Number:

R782.1

Song Wei, Ren Xiaoshan. Effect of serum ICAM-1 and MMP-8 levels in patients with dentition loss on prognosis after dental implant restoration[J]. Shanghai Journal of Stomatology, 2026, 35(2): 199-204.

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