Evaluation of the effect of stromal cell-derived factor 1α combined with platelet-rich fibrin in the treatment of permanent tooth avulsion

doi:10.19439/j.sjos.2026.02.011

Abstract

Abstract: PURPOSE: To evaluate the clinical effect of stromal cell-derived factor 1α (SDF-1α) combined with platelet-rich fibrin (PRF) in the treatment of permanent tooth avulsion. METHODS: A total of 72 patients (78 affected teeth) with permanent tooth avulsion who were admitted from April 2022 to January 2024 were selected and divided into the experimental group (36 cases, 40 affected teeth) and the control group (36 cases, 38 affected teeth) by random number table method.Both groups of patients underwent replantation treatment,after alveolar socket preparation, the control group was filled with PRF, and the experimental group was filled with PRF combined with SDF-1α. The success rate of replantation, postoperative occlusal pain, levels of growth factors [vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), fibroblast growth factor (FGF)], inflammatory factors [soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), C-reactive protein (CRP)] and complications were compared between the two groups. Results: The replantation success rate of the experimental group was 100.00% (40/40), significantly higher than that of the control group, which was 89.47%(34/38)(P<0.05).One week, one month, six months and twelve months after treatment, the pain degree scores of the two groups gradually decreased (P<0.05). One week and one month after treatment, the pain degree score of the experimental group was significantly lower than that of the control group (P<0.05). At 6 months and 12 months after treatment, there was no significant difference in the pain degree scores between the two groups (P>0.05). After treatment, the levels of VEGF, PDGF, TGF-βand FGF in both groups were significantly higher than those before operation, and the experimental group was significantly higher than the control group(P<0.05). After treatment, sICAM-1 in both groups was significantly higher than that before operation (P<0.05), IL-6 and CRP were significantly lower than those before operation(P<0.05). The postoperative sICAM-1 in the experimental group was significantly higher than that in the control group(P<0.05), and the levels of IL-6 and CRP were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups. CONCLUSIONS: Treatment of permanent tooth avulsion with SDF-1α combined with PRF can improve the replantation success rate of avulsed teeth, reduce postoperative pain responses, with good efficacy and safety.

Key words: Stromal cell-derived factor 1α, Platelet-rich fibrin, Permanent tooth avulsion

CLC Number:

R782.1

Guo Suzi, Yuan Chunli, Wuli Jitu, Liu Jing. Evaluation of the effect of stromal cell-derived factor 1α combined with platelet-rich fibrin in the treatment of permanent tooth avulsion[J]. Shanghai Journal of Stomatology, 2026, 35(2): 176-180.

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