Expression and clinical significance of SIRT1 and SOCS6 in gingival tissue of patients with severe chronic periodontitis

doi:10.19439/j.sjos.2025.05.011

Abstract

Abstract: PURPOSE: To investigate the expression and clinical significance of silent information regulator 1 (SIRT1) and suppressor of cytokine signaling 6(SOCS6) in gingival tissue of patients with severe chronic periodontitis (CP). METHODS: A total of 213 CP patients treated in Jiaxing Second Hospital from April 2022 to April 2024 were selected and divided into mild group (n=35), moderate group (n=91) and severe group (n=87) according to the severity of the disease. Another 95 patients with healthy periodontium who underwent crown lengthening were selected as control group. qRT-PCR was used to detect SIRT1 and SOCS6 mRNA expression levels in gingival tissues. Multivariate logistic regression was used to analyze the related factors affecting the occurrence of severe CP. Receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficacy of SIRT1 and SOCS6 expression levels in gingival tissues for severe CP. RESULTS: The levels of interleukin-10 (IL-10), C-reactive protein (CRP), and interleukin-17(IL-17) in the severe group were significantly higher than those in the moderate to mild group(P<0.05). The expression levels of SIRT1 and SOCS6 in the gingival tissue of the severe group were significantly lower than those of the moderate to mild group and the control group, the expression levels of SIRT1 and SOCS6 in the gingival tissue of the moderate to mild group were significantly lower than those of the control group (P<0.05). SIRT1, SOCS6, IL-10, and IL-17 in gingival tissue were related factors affecting the occurrence of severe CP (P<0.05). The area under the curve (AUC) of SIRT1, SOCS6, and their combination in the diagnosis of severe CP was 0.833, 0.825, and 0.896, respectively, which was superior to single indicator for diagnosis(P<0.05). The sensitivity and specificity of the combined diagnosis were 91.95% and 78.57%, respectively. CONCLUSIONS: The expression levels of SIRT1 and SOCS6 in gingival tissue of patients with severe CP are greatly reduced, which are related factors for severe CP. Detection of SIRT1 and SOCS6 has high diagnostic efficacy for severe CP.

Key words: Severe chronic periodontitis, Silent information regulator 1, Suppressor of cytokine signaling 6, Diagnostic efficiency

CLC Number:

R781.4

Yang Shaowei, Sheng Jian, Fei Chenyan, Cai Qi. Expression and clinical significance of SIRT1 and SOCS6 in gingival tissue of patients with severe chronic periodontitis[J]. Shanghai Journal of Stomatology, 2025, 34(5): 513-517.

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