关键词: 牙周炎, 唾液细菌, 微生物多样性

Abstract: PURPOSE: To explore whether oral hygiene and periodontal conditions of mothers had an impact on oral microbiota of newborns. METHODS: The oral health status of 48 mothers was examined and recorded. According to the mothers' periodontal status and the age of infants, the subjects were divided into 4 groups: one-month-old periodontitis group (n=17), one-month-old healthy group (n=18), six-month-old periodontitis group (n=7) and six-month-old healthy group(n=6). Through high-throughput sequencing of saliva samples of infants aged one month and six months, the impact of mother's periodontal status on oral microbial diversity of infants of the same month was analyzed. SPSS 23.0 software package was used for data analysis. RESULTS: In the two groups of one-month-old infants and the two groups of six-month-old infants, the oral microbial diversity in the healthy group was higher than that in the periodontitis group, but there was no significant difference. The species abundances of 12 species of Unclassified.Aggregatibacter, Unclassified. Ruminococcaceae, and Sp.Mycobacterium existed between the healthy group and the periodontitis group at the age of one month had significant difference. However, by the age of six months, only Elongata.Neisseria species was significantly different between the two groups. CONCLUSIONS: Different periodontal status of mothers has a certain influence on the microbial species diversity in the infant's oral cavity, and the difference in bacterial species abundance caused by this effect is more significant in one-month-old infants than in six-month-old infants.

Key words: Periodontitis, Saliva bacteria, Microbial diversity