上海口腔医学

上海口腔医学 ›› 2021, Vol. 30 ›› Issue (1): 85-88.doi: 10.19439/j.sjos.2021.01.017

• 论著 • 上一篇    下一篇

不同正畸治疗措施对错畸形患者龈沟液趋化因子CX3CL1、RANKL/OPG水平的影响

林嘉旭, 张汝弘, 张健娜, 巫晓平   

  1. 汕头市中心医院 口腔科,广东 汕头 515000
  • 收稿日期:2019-10-08 修回日期:2019-11-07 出版日期:2021-02-25 发布日期:2021-04-02
  • 通讯作者: 林嘉旭,E-mail：dentistljx@21cn.com
  • 作者简介:林嘉旭（1976-）,男,本科,副主任医师

Effects of different orthodontic treatments on sputum chemokines CX3CL1, RANKL/OPG levels in patients with malocclusion

LIN Jia-xu, ZHANG RU-hong, ZHANG Jian-na, WU Xiao-ping   

  1. Department of Stomatology, Shantou Central Hospital. Shantou 515000, Guangdong Province, China
  • Received:2019-10-08 Revised:2019-11-07 Online:2021-02-25 Published:2021-04-02

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摘要： 目的:探讨不同正畸治疗措施对错畸形患者龈沟液趋化因子CX3CL1、核因子κB受体活化因子配体/骨保护素（RANKL/OPG）水平的影响。方法:随机将96例拟采取正畸治疗的错畸形患者分为4组,所有患者均采用方丝弓矫治器治疗,分别给予0、50、150、250 g的远中正畸力。观察4组患者治疗1、2、3、4周后龈沟液中CX3CL1、RANKL/OPG水平。采用SPSS 25.0软件包对数据进行统计学分析。结果:4组患者治疗1~3周后,龈沟液中CX3CL1、RANKL、RANKL/OPG水平持续上升,治疗4周后出现下降（P<0.05）;治疗1~3周后,龈沟液中OPG处于较低水平,治疗4周后出现上升（P<0.05）。龈沟液中CX3CL1、RANKL、OPG、RANKL/OPG水平在A、B、C、D组逐渐增高（P<0.05）,各组间相比,差异均有统计学意义（P<0.05）。结论:龈沟液中CX3CL1、RANKL/OPG水平与正畸力度和治疗时间关系密切,其动态水平变化可作为评估正畸治疗牙槽骨改建的重要指标。

关键词: 正畸治疗, 错畸形, 龈沟液, CX3CL1, RANKL/OPG

Abstract: PURPOSE: To investigate the effects of different orthodontic treatments on gingival crevicular fluid chemokine CX3CL1, nuclear factor κB receptor activating factor ligand/osteoprotegerin(RANKL/OPG) levels in patients with malocclusion. METHODS: Ninety-six patients with malocclusion who were scheduled to undergo orthodontic treatment were randomly divided into four groups. All patients were treated with square wire appliance, and 0, 50, 150, 250 g of far-distal orthodontic force were given respectively. The levels of CX3CL1 and RANKL/OPG in gingival crevicular fluid were detected in four groups after 1, 2, 3, and 4 weeks of treatment. SPSS 25.0 software package was used for statistical analysis of the date. RESULTS: The levels of CX3CL1, RANKL and RANKL/OPG in the gingival crevicular fluid of the four groups were continuously increased after treatment for 1-3 weeks, and decreased after 4 weeks of treatment (P<0.05). The OPG in the gingival crevicular fluid was at a low level after 1-3 weeks of treatment. There was an increase after 4 weeks of treatment (P<0.05). The levels of CX3CL1, RANKL, OPG and RANKL/OPG in gingival crevicular fluid increased gradually in group A, B, C and D (P<0.05), and the differences between the groups were statistically significant (P<0.05).CONCLUSIONS: The levels of CX3CL1 and RANKL/OPG in gingival crevicular fluid are closely related to orthodontic force and treatment time, and can be used as an index to evaluate orthodontic treatment of alveolar bone remodeling.

Key words: Orthodontic treatment, Malocclusion, Gingival crevicular fluid, CX3CL1, RANKL/OPG

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