CFL-1在头颈部鳞癌中的表达与患者预后的关系

doi:10.19439/j.sjos.2024.02.007

上海口腔医学 ›› 2024, Vol. 33 ›› Issue (2): 148-155.doi: 10.19439/j.sjos.2024.02.007

CFL-1在头颈部鳞癌中的表达与患者预后的关系

赵开¹, 张宇宁¹, 纪帅旗², 刘颖¹, 姜涵¹

1.苏州大学附属第四医院口腔科,苏州市独墅湖医院,苏州大学医学中心,江苏苏州 215000;
2.福建医科大学口腔医院预防牙科,福建省口腔疾病重点实验室,福建医科大学口腔医学院,福建福州 350000

收稿日期:2023-03-28 修回日期:2023-06-21 出版日期:2024-04-25 发布日期:2024-05-14
通讯作者: 姜涵, E-mail：363528495@qq.com
作者简介:赵开（1994-）,男,硕士,住院医师,E-mail：1142083797@qq.com
基金资助:
苏州市科技计划项目（自贸区生物医药创新发展强链补链科技专项-医工结合协同创新研究SZM2023015）

The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma

ZHAO Kai¹, ZHANG Yu-ning¹, JI Shuai-qi², LIU Ying¹, JIANG Han¹

1. Department of Stomatology, The Fourth Affiliated Hospital of Soochow University; Suzhou Dushu Lake Hospital, Medical Center of Soochow University. Suzhou 215000, Jiangsu Province;
2. Department of Preventive Dentistry, Stomatology Hospital, Fujian Medical University; Fujian Provincial Key Laboratory of Stomatology, School of Stomatology of Fujian Medical University. Fuzhou 350000, Fujian Province, China

Received:2023-03-28 Revised:2023-06-21 Online:2024-04-25 Published:2024-05-14

摘要/Abstract

摘要： 目的: 探索Cofilin 1蛋白（Cofilin 1 protein,CFL-1）在头颈部鳞状细胞癌（head and neck squamous cell carcinoma,HNSCC）中的表达、预后价值和免疫相关性。方法: 在癌症基因组图谱数据库（cancer genome map database,TCGA）和基因表达总数据库（gene expression total databases,GEO）中,分析CFL-1在HNSCC中的表达及预后价值,通过基因集富集分析（gene set enrichment analysis,GESA）、cibersoft明确CFL-1在HNSCC组织中的分子通路。采用SPSS 26.0软件包对数据进行统计学分析。结果: CFL-1在HNSCC组织中显著上调。CFL-1高表达组与较低的总生存率显著相关。多因素Cox生存分析表明,CFL-1表达是HNSCC预后不良的独立预测因素。GESA、cibersoft分析表明,CFL-1表达失调影响多条信号通路,并影响免疫细胞的局部浸润。结论: CFL-1在HNSCC中高表达,并与不良预后显著相关,是HNSCC的潜在标志物。

关键词: CFL-1, 头颈部鳞癌, 免疫浸润, 预后, 标志物

Abstract: PURPOSE: The purpose of this study was to explore the expression, prognostic value and immune correlation of Cofilin 1 protein(CFL-1) in head and neck squamous cell carcinoma(HNSCC). METHODS: The expression and prognostic value of CFL-1 in head and neck squamous cell carcinoma(HNSCC) was explored in the cancer genome map database (TCGA) and gene expression total databases (GEO), and the potential immune pathway of CFL-1 in HNSCC was revealed by GESA and cibersoft analysis. The data were statistically analyzed using SPSS 26.0 software package. RESULTS: CFL-1 was significantly up-regulated in HNSCC tissue. The expression level of CFL-1 was significantly correlated with the overall survival status of HNSCC. High expression of CFL-1 was significantly associated with a lower overall survival rate. In addition, multivariate Cox survival analysis showed that CFL-1 expression was independent predictors of poor prognosis of HNSCC. GESA and cibersoft analysis showed that the imbalance of CFL-1 expression affected multiple signal pathways and infiltration of immune cells. CONCLUSIONS: CFL-1 is highly expressed in HNSCC and is significantly associated with poor prognosis of NHSCC. It is a potential prognostic marker of HNSCC.

Key words: CFL-1, Head and neck squamous cell carcinoma, Immune infiltration, Prognosis, Marker

中图分类号:

R739.8

赵开, 张宇宁, 纪帅旗, 刘颖, 姜涵. CFL-1在头颈部鳞癌中的表达与患者预后的关系[J]. 上海口腔医学, 2024, 33(2): 148-155.

ZHAO Kai, ZHANG Yu-ning, JI Shuai-qi, LIU Ying, JIANG Han. The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2024, 33(2): 148-155.

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CFL-1在头颈部鳞癌中的表达与患者预后的关系

The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma

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