关键词: 自体牙本质颗粒, Bio-Oss骨粉植入, 引导骨再生, 牙周骨缺损

Abstract: PURPOSE: To analyze the effect of autologous dentin particles and Bio-Oss bone powder implantation on guided bone regeneration in the treatment of periodontal bone defects. METHODS: Eighty-two patients with periodontal bone defect treated in Zhangye People's Hospital from May 2018 to May 2020 who underwent guided bone regeneration treatment were selected and divided into experimental group and control group according to random number table method, with 41 cases in each group. The control group was implanted with Bio-Oss during the operation, and the experimental group was implanted with autologous dentin particles during operation. Periodontal pocket depth and attachment loss, buccal soft tissue profile, buccal soft tissue thickness, red aesthetic score, success rate, and complications were compared between the two groups of patients. SPSS 22.0 software package was used for statistical analysis. RESULTS: Comparison within the group showed that 1 month and 1 year after operation, the periodontal pocket depth and attachment loss of the two groups were significantly reduced(P<0.05); and 1 year after operation, the periodontal pocket depth and attachment loss of the two groups were significantly lower than 1 month after surgery(P<0.05). Comparison between groups showed that 1 month and 1 year after operation, the periodontal pocket depth and attachment loss of the experimental group were significantly lower than those of the control group (P<0.05). Comparison within groups showed that 1 month and 1 year after operation, the buccal soft tissue profile of the two groups were significantly higher than that before operation (P<0.05); and 1 year after operation, the buccal soft tissue profile of the two groups were significantly lower than 1 month after operation. Comparison between groups showed that 1 year after operation, the buccal soft tissue profile of the experimental group was significantly higher than that of the control group (P<0.05). Comparison within groups showed that 1 month and 1 year after surgery, the thickness of the buccal soft tissue of the two groups were significantly higher than that before surgery. Comparison between groups showed that there was no significant difference in the thickness of the buccal soft tissue at each time point between the two groups(P>0.05). Comparison within groups showed that 1 month and 1 year after operation, the red aesthetic scores of patients in the two groups were significantly higher than those before operation (P<0.05); in addition, the red aesthetic scores of the two groups 1 year after surgery were significantly higher than those 1 month after surgery (P<0.05). Comparison between groups showed that 1 month and 1 year after surgery, the red aesthetic scores of the experimental group were significantly higher than those of the control group (P<0.05). One year after operation, the success rate of the experimental group and the control group were 90.24% (37/41) and 85.37% (35/41), respectively, and there was no significant difference between the two groups(P>0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05). CONCLUSIONS: Autologous dentin particles can be used to guide bone regeneration to treat patients with periodontal bone defects, which can reduce the depth of periodontal pockets and loss of attachment, improve the buccal soft tissue profile and red aesthetic score, and the success rate is equivalent to implantation of Bio-Oss. Therefore, it is a safe and reliable treatment method.

Key words: Autologous dentin particles, Bio-Oss bone meal implantation, Guided bone regeneration, Periodontal bone defect