大黄提取物治疗伴糖尿病重度牙周炎的疗效观察

doi:10.19439/j.sjos.2018.06.014

上海口腔医学 ›› 2018, Vol. 27 ›› Issue (6): 633-636.doi: 10.19439/j.sjos.2018.06.014

大黄提取物治疗伴糖尿病重度牙周炎的疗效观察

李月玲¹, 李亦凡², 周煜宗³, 杨佳音¹, 冉幸¹

1.上海市嘉定区牙病防治所,上海 201899;
2.上海市嘉定区中医医院麻醉科,上海 201821;
3.复旦大学附属华山医院输血科,上海 200040

收稿日期:2018-05-25 出版日期:2018-12-25 发布日期:2019-01-11
通讯作者: 冉幸,E-mail：395350498@qq.com
作者简介:李月玲（1961-）,女,博士,主任医师,E-mail:liyueling61@163.com

The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus

LI Yue-ling¹, LI Yi-fan², ZHOU Yu-zong³, YANG Jia-yin¹, RAN Xing¹

1. Dental Diseases Prevention and Treatment Center of Jiading District. Shanghai 201899;
2. Department of Anesthesiology, The Traditional Chinese Medical Hospital of Jiading District. Shanghai 201821;
3. Department of Blood Transfusion, Huashan Hospital, Fudan University. Shanghai 200040, China

Received:2018-05-25 Online:2018-12-25 Published:2019-01-11
Supported by:
上海市嘉定区农业和社会事业科研项目（JDKW-2017-W06）

摘要/Abstract

摘要： 目的: 观察大黄提取物局部应用治疗伴糖尿病重度牙周炎的临床疗效。方法: 将50例伴糖尿病的重度牙周炎患者随机分为对照组（龈下刮治和根面平整术）和实验组（龈下刮治和根面平整术+术后局部应用大黄提取物软膏）。2组患者均在治疗前、治疗后6周、治疗后12周检查牙周探诊深度(probing pocket depth, PD)、临床附着水平(clinical attachment level, CAL)、探诊出血指数(bleeding on probing, BOP)。采用SPSS 20.0软件包对实验数据进行统计学分析。结果: 相比治疗前,2组患者在治疗后6周和治疗后12周, PD、CAL、BOP均有下降,实验组低于对照组,有统计学差异。表明2组患者经过治疗后牙周状况都有明显改善,实验组改善优于对照组。整个实验过程中未发生药物不良反应。结论: 大黄提取物局部应用辅助治疗伴糖尿病的重度牙周炎有良好的临床疗效。

关键词: 大黄提取物, 重度牙周炎, 糖尿病, 临床疗效

Abstract: PURPOSE: To observe the curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus. METHODS: Fifty patients with severe periodontitis and diabetes mellitus were randomly divided into 2 groups. The patients in the control group were treated with scaling and root planning(SRP); while patients in the experimental group were treated with SRP followed by topical use of rhubarb extract. Periodontal index probing pocket depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were examined before periodontal treatment,6 weeks and 12 weeks after treatment. SPSS 20.0 software package was used for statistical analysis. RESULTS: Significant improvement in periodontal condition was noted in both groups after treatment, and the degree of improvement was greater in the experimental group than in the control group. No adverse event during the entire study was found. CONCLUSIONS: Topical application of rhubarb extract for the treatment of severe periodontitis with diabetes has good clinical efficacy.

Key words: Rhubarb extract, Severe periodontitis, Diabetes, Clinical efficacy

中图分类号:

R781.4.2

李月玲, 李亦凡, 周煜宗, 杨佳音, 冉幸. 大黄提取物治疗伴糖尿病重度牙周炎的疗效观察[J]. 上海口腔医学, 2018, 27(6): 633-636.

LI Yue-ling, LI Yi-fan, ZHOU Yu-zong, YANG Jia-yin, RAN Xing. The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus[J]. Shanghai Journal of Stomatology, 2018, 27(6): 633-636.

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大黄提取物治疗伴糖尿病重度牙周炎的疗效观察

The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus

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