Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中的表达及意义

上海口腔医学 ›› 2015, Vol. 24 ›› Issue (1): 89-93.

Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中的表达及意义

孔丽,王炳超,袁荣涛,贾暮云,王科

青岛大学附属医院口腔颌面外科,山东青岛 266003

收稿日期:2014-04-21 出版日期:2015-02-20 发布日期:2015-07-24
通讯作者: 袁荣涛,Tel:0532-82911359,E-mail:yuanrongtao@163.com
作者简介:孔丽（1989-）,女,硕士研究生,E-mail:lilykong9053@163.com
基金资助:
青岛市公共领域科技支撑计划项目[11-2-3-1-(20)-nsh]

Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones

KONG Li,WANG Bing-chao,YUAN Rong-tao,JIA Mu-yun,WANG Ke

Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China

Received:2014-04-21 Online:2015-02-20 Published:2015-07-24
Supported by:
Qingdao Municipal Science and Technology Support Program in the Public Domain [11-2-3-1 - (20)-nsh]

摘要/Abstract

摘要： 目的研究Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中的表达,探讨其发挥的调控作用。方法收集颌骨牙源性角化囊性瘤新鲜标本及同一患者的正常口腔黏膜,提取RNA,基因芯片检测Wnt信号通路的相关基因,进行生物信息学分析。结果颌骨牙源性角化囊性瘤与正常口腔黏膜相比,在Wnt信号通路相关基因中发现5个共同差异表达基因,其中CAMK2A下调, FZD3、MAPK10、PRKX、WNT5a上调。结论牙源性角化囊性瘤中存在Wnt信号通路基因的异常表达,Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中发挥一定的调控作用。

关键词: 牙源性角化囊性瘤, Wnt信号通路, 寡链核苷酸分析

Abstract: PURPOSE: To study the role of genes of Wnt signaling pathway in keratocystic odontogenic tumor (KCOT) of the jaw bones. METHODS: Fresh specimens of KCOT and the same patient 's normal oral mucosa were obtained. Then RNA was extracted. Gene chip was used to detect the genes of Wnt signaling pathway. RESULTS: Compared to normal oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2A down-regulated, FZD3, MAPK10, PRKX and WNT5a up-regulated. CONCLUSIONS: There are abnormal expressions of genes of Wnt pathway in KCOT. Genes of Wnt pathway plays certain roles in KCOT.

Key words: Keratocystic odontogenic tumor, Wnt signaling pathway, Oligonudeotide array sequence analysis

中图分类号:

R739.8

孔丽,王炳超,袁荣涛,贾暮云,王科. Wnt信号通路相关基因在颌骨牙源性角化囊性瘤中的表达及意义[J]. 上海口腔医学, 2015, 24(1): 89-93.

KONG Li,WANG Bing-chao,YUAN Rong-tao,JIA Mu-yun,WANG Ke. Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones[J]. Shanghai Journal of Stomatology, 2015, 24(1): 89-93.

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