核因子κB受体活化因子配体在牙源性角化囊性瘤开窗减压前、后的表达

doi:10.19439/j.sjos.2017.04.017

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (4): 434-436.doi: 10.19439/j.sjos.2017.04.017

核因子κB受体活化因子配体在牙源性角化囊性瘤开窗减压前、后的表达

张波¹, 叶文成¹, 李莹¹, 周新木², 毛卫波², 朱忆凌²

1.浙江大学丽水医院·丽水市中心医院口腔科,
2.病理科,浙江丽水 323000

收稿日期:2017-01-15 修回日期:2017-04-06 出版日期:2017-08-25 发布日期:2017-09-01
通讯作者: 叶文成,E-mail:13957079750@163.com
作者简介:张波（1981-）,男,硕士,主治医师,E-mail:studiobzzb@163.com
基金资助:
丽水市公益性技术应用项目（2013JYZB28）

Expression of receptor activator of nuclear factor-κB ligand in keratocystic odontogenic tumor before and after decompression

ZHANG Bo¹, YE Wen-cheng¹, LI Ying¹, ZHOU Xin-mu², MAO Wei-bo², ZHU Yi-ling²

1.Department of Stomatology,
2.Department of Pathology, Lishui Hospital of Zhejiang University, Lishui Central Hospital. Lishui 323000, Zhejiang Province, China

Received:2017-01-15 Revised:2017-04-06 Online:2017-08-25 Published:2017-09-01

摘要/Abstract

摘要： 目的观察核因子κB受体活化因子配体（RANKL）在牙源性角化囊性瘤（KOCT）开窗减压前、后的表达,探讨开窗减压治疗KCOT的可能机制。方法收集22例经病理证实为KCOT的患者开窗减压治疗前、后的标本,进行RANKL免疫组织化学染色,采用SPSS17.0软件包对数据进行配对t检验。结果22例KCOT开窗减压前衬里上皮中均有RANKL的阳性表达,开窗减压后RANKL表达水平下降,开窗前、后的RANKL表达有显著差异（P<0.05）。结论RANKL在KCOT囊壁上皮中呈高表达,开窗减压后表达水平降低,可促进囊壁衬里上皮向正常口腔黏膜上皮转化。

关键词: 核因子κ, B受体活化因子配体, 牙源性角化囊性瘤, 开窗减压术

Abstract: To investigate the expression of receptor activator of nuclear factor-κB ligand (RANKL) in keratocystic odontogenic tumor (KCOT) before and after decompression. METHODS: Twenty two pairs of paraffin-embeded tissue specimens of KCOT were collected and subjected to immunohistochemical analysis of RANKL.The data were analyzed with SPSS17.0 software package for paired t test. RESULTS: RANKL positive cells were observed in the preoperative KCOT epithelium. The expression of RANKL was down-regulated after decompression(P<0.05).CONCLUSIONS: Decrease of RANKL expression after decompression may facilitate the lining epithelium of KCOT transforming to normal oral mucosal epithelium.

Key words: Receptor activator of nuclear factor-κ, B ligand, Keratocystic odontogenic tumor, Decompression

中图分类号:

R739.82

张波, 叶文成, 李莹, 周新木, 毛卫波, 朱忆凌. 核因子κB受体活化因子配体在牙源性角化囊性瘤开窗减压前、后的表达[J]. 上海口腔医学, 2017, 26(4): 434-436.

ZHANG Bo, YE Wen-cheng, LI Ying, ZHOU Xin-mu, MAO Wei-bo, ZHU Yi-ling. Expression of receptor activator of nuclear factor-κB ligand in keratocystic odontogenic tumor before and after decompression[J]. Shanghai Journal of Stomatology, 2017, 26(4): 434-436.

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核因子κB受体活化因子配体在牙源性角化囊性瘤开窗减压前、后的表达

Expression of receptor activator of nuclear factor-κB ligand in keratocystic odontogenic tumor before and after decompression

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