双氯芬酸含漱液对放射性口腔黏膜炎的止痛效果观察

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (3): 356-358.

双氯芬酸含漱液对放射性口腔黏膜炎的止痛效果观察

谢宁¹, 庞劲松¹, 徐华顺¹, 俞晓立²

1.上海市第八人民医院口腔科,上海 200235;
2.复旦大学附属肿瘤医院放疗科,复旦大学上海医学院肿瘤学系,上海 200032

收稿日期:2014-02-26 出版日期:2014-06-20 发布日期:2014-09-09
通讯作者: 俞晓立,E-mail: stephanieyxl@hotmail.com
作者简介:谢宁(1976-), 女, 学士, 主治医师, E-mail:happy.rosemary@gmail.com

Analgesic effect of DICLORAL on radiation-induced oral mucositis

XIE Ning¹, PANG Jin-song¹, XU Hua-shun¹, YU Xiao-li²

1.Department of Stomatology, Shanghai Eighth People’s Hospital.Shanghai 200235;
2.Department of Radiation Oncology, Fudan University, Shanghai Cancer Center.Shanghai 200032, China

Received:2014-02-26 Online:2014-06-20 Published:2014-09-09

摘要/Abstract

摘要： 目的:评价双氯芬酸含漱液(DICLORAL)对放射性口腔黏膜炎所引起的疼痛的临床疗效。方法:将59 例因鼻腔NK/T细胞淋巴瘤而接受放疗导致放射性口腔黏膜炎的患者随机分为试验组(30例)和对照组(29例),试验组采用双氯芬酸含漱液,对照组采用复方硼酸含漱液。观察静态疼痛强度和吞咽疼痛强度的改变以及止痛起效时间和维持时间。采用SPSS16.0软件包对数据进行统计学分析。结果:2组的静态疼痛强度和吞咽疼痛强度的改变、止痛起效时间无显著差异(P>0.05),试验组的维持时间显著长于对照组(P<0.05) 。结论: 双氯芬酸含漱液能有效地缓解和消除放射性口腔黏膜炎引起的疼痛,疗效维持长于复方硼酸含漱液。

关键词: 双氯芬酸含漱液, 放射性口腔黏膜炎, 止痛

Abstract: PURPOSE: To assess the effects of DICLORAL’s alleviation of pain caused by radiation-induced oral mucositis. METHODS:With compound borax solution as a comparative drugs, the solution of DICLORAL was adopted for patients with radiation-induced oral mucositis due to radiotherapy for nasal NK/T cell lymphoma. All 59 patients were randomly divided into 2 groups: experimental group (using DICLORAL) and control group (using Compound Borax Solution). During the treatment, we observed drugs’ ability of alleviate oral pain or pain on swallowing, when it worked and how long it could sustain in controlling pain. Statistical analysis was performed using SPSS 16.0 software package. RESULTS: Drugs’ ability of alleviate oral pain or pain on swallowing and the onset time was not significantly different between the 2 groups (P>0.05). Effective duration in experimental group was longer than that in control group (P<0.05). CONCLUSIONS: DICORAL can alleviate and cease pain caused by radiation-induced oral mucositis effectively.

Key words: DICLORAL, Radiation-induced oral mucositis, Analgesic

中图分类号:

R781. 5

谢宁, 庞劲松, 徐华顺, 俞晓立. 双氯芬酸含漱液对放射性口腔黏膜炎的止痛效果观察[J]. 上海口腔医学, 2014, 23(3): 356-358.

XIE Ning, PANG Jin-song, XU Hua-shun, YU Xiao-li. Analgesic effect of DICLORAL on radiation-induced oral mucositis[J]. Shanghai Journal of Stomatology, 2014, 23(3): 356-358.

参考文献

[1] Lima M. Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis[J]. Orphanet J Rare Dis, 2013,8(1):95.
[2] Yamaguchi M.Current and future management of NK/T-cell lymphoma based on clinical trials[J]. Int J Hematol, 2012,96(5):562-571.
[3] Lee J, Kim CY, Park YJ, et al. Sequential chemotherapy followed by radiotherapy versus concurrent chemoradiotherapy in patients with stage I/II extranodal natural killer/T-cell lymphoma, nasal type[J]. Blood Res, 2013,48(4):274-281.
[4] Trotti A, Bellm LA, Epstein JB, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review[J]. Radiother Oncol, 2003,66(3):253-262.
[5] 林高娟,杨敏,唐玉平,等. 穿心草防治鼻咽癌放射性口腔黏膜反应的临床研究[J]. 现代肿瘤医学,2012,20(9):1817-1819.
[6] 张瑞光. 复方苦参注射液治疗鼻咽癌放射性口腔黏膜损伤疗效研究[D]. 昆明医科大学硕士学位论文,2013.
[7] Song JJ, Twumasi-Ankrah P, Salcido R. Systematic review and meta-analysis on the use of honey to protect from the effects of radiation-induced oral mucositis[J]. Adv Skin Wound Care, 2012,25(1):23-28.
[8] Saunders DP, Epstein JB, Elad S, et al. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients[J]. Support Care Cancer, 2013,21(11):3191-3207.
[9] 周永梅,周曾同. 双氯芬酸钠含片治疗口腔溃疡性疼痛的临床研究[J]. 临床口腔医学杂志, 2004,20(5):310-312.
[10] 卢勇涛. 复方硼酸含漱液的药理毒理学研究[D]. 南方医科大学硕士学位论文,2010.
[11] Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer[J]. Dent Clin North Am, 2008,52(1):61-77.
[12] Simone JL, Jorge WA, Horliana AC, et al. Comparative analysis of preemptive analgesic effect of dexamethasone and diclofenac following third molar surgery[J]. Braz Oral Res, 2013,27(3):266-271.
[13] 麦伟持, 盛薇, 秦霞南, 等. 双氯芬酸钠喷雾剂治疗复发性阿弗他溃疡疗效观察[J]. 广东牙病防治,2010,18(8):411-413.
[14] Saxen MA1, Ambrosius WT, Rehemtula al-KF, et al. Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan: a randomized double-blind clinical trial[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1997,84(4):356-361.
[15] 刘源, 周同冲, 宋先璐,等. 双氯芬酸钠喷雾剂治疗急性放射性口腔、口咽黏膜炎临床疗效观察[J]. 国际医药卫生导报, 2012,18(7):985-988.