上海口腔医学

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (3): 317-321.

• 临床研究 • 上一篇    下一篇

环氧化酶2、X染色体连锁凋亡抑制蛋白在唾液腺恶性肿瘤中的表达及意义

宁兆荣1, 李松2, 郭延伟1, 房殿吉3   

  1. 1.佳木斯大学附属口腔医院 口腔颌面外科,黑龙江 佳木斯 154002;
    2.长春市口腔医院 口腔颌面外科,吉林 长春 130000;
    3.复旦大学附属上海市第五人民医院 口腔科,上海 200240
  • 收稿日期:2013-07-31 出版日期:2014-06-20 发布日期:2014-09-09
  • 通讯作者: 房殿吉,E-mail:dianjifang@126.com
  • 作者简介:宁兆荣(1987-), 女, 硕士, E-mail:ningzhaorong1987@126.com
  • 基金资助:
    国家自然科学基金(81170935)

Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland

NING Zhao-rong1, LI Song2, GUO Yan-wei1, FANG Dian-ji3   

  1. 1.Department of Oral and Maxillofacial Surgery, Jiamusi University Hospital of Stomatology. Jiamusi 154002, Heilongjiang Province;
    2.Department of Oral and Maxillofacial Surgery, Changchun Hospital of Stomatology. Changchun 130000, Jilin Province;
    3.Department of Oral and Maxillofacial Surgery, The Fifth People’s Hospital of Fudan University. Shanghai 200240, China
  • Received:2013-07-31 Online:2014-06-20 Published:2014-09-09
  • Supported by:
    Supported by National Natural Science Foundation of China (81170935).

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摘要： 目的: 检测环氧化酶2(Cox-2)与X染色体连锁凋亡抑制蛋白(XIAP)在唾液腺腺样囊性癌(ACC)与黏液表皮样癌(MEC)中的表达,探讨两者在唾液腺恶性肿瘤发生、发展中的作用及相关性。方法:采用免疫组织化学SP法检测95例唾液腺恶性肿瘤(包括50例ACC、45例MEC)、10例多形性腺瘤及10例正常唾液腺组织中Cox-2和XIAP的表达情况,使用SPSS17.0软件包对数据进行统计学处理。结果:Cox-2、XIAP在唾液腺恶性肿瘤中高表达,在多形性腺瘤和正常唾液腺组织中不表达或低表达。Cox-2、XIAP的表达与唾液腺恶性肿瘤组织临床分期和远处转移呈正相关(P<0.05),而与肿瘤部位无相关性(P>0.05)。结论:Cox-2和XIAP在唾液腺恶性肿瘤中高表达,可能在唾液腺恶性肿瘤发生、发展过程中具有重要作用。

关键词: 环氧化酶2, X染色体连锁凋亡抑制蛋白, 腺样囊性癌, 黏液表皮样癌

Abstract: PURPOSE: To detect the expression of Cox-2 and XIAP in adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) of salivary glands. To study the role and correlation between the expression of Cox-2 and XIAP in malignant tumors of salivary gland. METHODS: Immunohistochemical SP staining method was used to quantify the protein expression levels of Cox-2 and XIAP in 95 patients with malignant tumors of the salivary gland (50 ACCs,45 MECs),10 patients with pleomorphic adenoma and 10 persons with normal salivary gland tissues. SPSS17.0 software package was used to analyze the data. RESULTS: Cox-2 and XIAP were expressed strongly in malignant tumors of the salivary gland, while they not expressed in pleomorphic adenoma and normal salivary gland tissues. The expression of Cox-2 and XIAP in malignant tumors of salivary gland was correlated with clinical stage and lymphnode metastasis, while they not correlated with primary sites (P>0.05). CONCLUSIONS: The high expression of Cox-2 and XIAP in malignant tumors of salivary gland may play an important role in the development of malignant tumors of the salivary gland.

Key words: Cox-2, XIAP, Adenoid cystic carcinoma, Mucoepidermoid carcinoma

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