上海口腔医学

上海口腔医学 ›› 2013, Vol. 22 ›› Issue (6): 671-675.

• 临床研究 • 上一篇    下一篇

儿茶酚胺水平与口腔鳞癌患者精神心理因素变化的关系

李博1,2，李黎3，郭黛墨1，潘唯一1，段泽西1，黄一冰1，邹晓莉4，朱彩蓉4，谢蟪旭1,2   

  1. (1.四川大学华西口腔医学院，四川 成都 610041；2.口腔疾病研究国家重点实验室，四川 成都 610041；3.四川大学华西附属第二医院 病案管理科，四川 成都 610041；4.四川大学华西公共卫生学院，四川 成都 610041)
  • 收稿日期:2013-05-05 修回日期:2013-07-12 出版日期:2013-04-12 发布日期:2013-04-12
  • 通讯作者: 谢蟪旭，Tel：028-85501428，E-mail：aitian007@126.com
  • 作者简介:李博(1992-)，男，在读本科生，E-mail：965774655@qq.com
  • 基金资助:
    国家自然科学基金(81172578)；国家大学生创新训练计划项目(201210610096)

Assessment of mental health status in oral squamous cell carcinoma patients and its correlation with catecholamines level

LI Bo1,2, LI Li3, GUO Dai-mo1, PAN Wei-yi1, DUAN Ze-xi1, HUANG Yi-bing1, ZOU Xiao-li3, ZHU Cai-rong3, XIE Hui-xu1,2   

  1. 1.West China School of Stomatology, Sichuan University. Chengdu 610041; 2.State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University. Chengdu 610041; 3.Department of Medical Management, West China Second University Hospital, Sichuan University. Chengdu 610041; 4.West China School of Public Health, Sichuan University. Chengdu 610041, Sichuan Province, China
  • Received:2013-05-05 Revised:2013-07-12 Online:2013-04-12 Published:2013-04-12
  • Supported by:
    Supported by National Natural Science Foundation of China (81172578) and Natural University Students Innovation Training Program (201210610096).

PDF (PC)

313

被引次数

9

摘要： 目的：了解口腔鳞癌患者精神心理因素状况与体内儿茶酚胺类物质水平变化的相互关系，探索两者相关性对疾病进程的影响。方法：纳入口腔鳞癌患者40例，应用症状自评量表(SCL90)按照0-4的5级评分标准，测评每位受试者的精神心理状况。于入院次日上午9点抽取受试者的全血，切取新鲜术后肿瘤组织，分离、提取血清，匀浆肿瘤组织，采用高效液相色谱-质谱(HPLC-MS-MS)分析血清中以及肿瘤组织中儿茶酚胺含量。采用SPSS19.0软件包对数据进行统计学分析。结果：与国内常模症状自评量表评分比较，口腔鳞癌患者总分以及除人际关系外的单项因子分值均高于国内常模；其血清肾上腺素(E)、血清去甲肾上腺素(NE)、肿瘤组E以及肿瘤组织NE含量分别为(70.27±34.50) pg/mL、(316.73±109.22) pg/mL、(6.66±3.85) pg/mg和(12.67±5.27) pg/mg。随着血中NE、E水平升高，鳞癌患者临床分期及病理分级也增高，两者间有相关性。结论：口腔鳞癌患者存在明显的精神心理因素变化，同时伴有体内儿茶酚胺类物质水平明显升高，并与肿瘤的临床分期密切相关。

关键词: 症状自评量表, 口腔鳞癌, 高效液相色谱, 质谱, 儿茶酚胺

Abstract: PURPOSE: To investigate the relationship between mental health status and catecholamines level in oral squamous cell carcinoma patients. METHODS: Forty patients with oral squamous carcinoma (OSCC) who were diagnosed in West China School of Stomatology between Dec. 2011 and Aug. 2012, were assessed with symptom checklist-90 (the 5-grade scoring of 0 to 4 points was used) independently according to their actual conditions. Blood sample was taken on the second admission day and fresh tumor tissue with the weight of 0.5 g was obtained. A method was developed for determination of catecholamine and glucocorticoid in serum using liquid chromatography-tandem mass spectrometry (HPLC-MS-MS). SPSS19.0 software package was used for statistical analysis. RESULTS: Forty patients were included in the study. Compared with the scores of SCL-90 in national norms, the scores were all higher in oral squamous carcinoma patients except the interpersonal relationship. Epinephrine(E) and norepinephrine(NE) in serum was (70.27±34.50) pg/mL and (316.73±109.22) pg/mL, respectively. E and NE in tumor tissues was (6.66±3.58) pg/mg and (12.67±5.27) pg/mg respectively. As the concentrations of NE and E from circulating serum increasing, the stage and grade of oral squamous carcinoma were promoted. CONCLUSIONS: Psychiatric factors have an important impact on OSCC patients. The increased level of catecholamines is closely related to clinical stage and grade of OSCC.

Key words: Symptom checklist-90, Oral squamous carcinoma, Liquid chromatography, Mass spectrometry；Catecholamines

中图分类号: