PD-L1的表达与口腔鳞癌预后及临床病理特征相关性的meta分析

doi:10.19439/j.sjos.2018.01.023

摘要/Abstract

摘要： 目的: 采用meta分析评价PD-L1的表达与口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）预后及临床病理特征的关系。方法: 检索PubMed、EMBASE以及Cochrane等数据库中关于PD-L1蛋白表达与OSCC预后和临床病理特征相关的实验研究,采用RevMan 5.3软件进行meta分析。结果: 最终纳入12个研究共1595例患者。Meta分析合并风险比（HR）为1.02（95%CI= 0.93-1.11,P=0.71）,表明PD-L1的表达与OSCC生存率无显著相关性。合并比值比（OR）显示,PD-L1与患者性别（OR=0.64,95%CI=0.48-0.85,P=0.002）、肿瘤分化程度（OR=0.58,95%CI=0.37-0.90,P=0.01）以及是否合并HPV感染（OR=1.91,95%CI=1.13-3.23,P=0.02）密切相关,但与肿瘤大小、颈淋巴结转移无明显相关性。结论: PD-L1的表达并不能作为判断OSCC预后的独立因素。在临床病理特征方面,PD-L1的表达与患者性别、肿瘤分化程度、HPV感染有显著相关性。该结论尚待更大样本的研究予以验证。

关键词: 口腔鳞癌, PD-L1, HPV, PD-1, Meta分析

Abstract: PURPOSE: To determine the prognostic role of high PD-L1 in patients with oral squamous cell carcinoma. METHODS: Electronic databases, such as PubMed, Embase and Cochrane library, were searched to identify studies evaluating PD-L1 expression and overall survival (OS) in these patients. RevMan 5.3 software was used for meta-analysis. RESULTS: A total of 12 studies that involved 1595 patients were included. Pooled hazard ratio (HR) 1.02 (95%CI= 0.93-1.11,P=0.71) indicated that the association between PD-L1 expression and overall survival (OS) was not significant. The pooled odds ratios (ORs) indicated that PD-L1 expression was associated with gender (OR=0.64, 95%CI=0.48-0.85, P=0.002), differentiation (OR=0.58, 95%CI=0.37-0.90, P=0.01) and HPV infection (OR=1.91, 95%CI=1.13-3.23, P=0.02). However, PD-L1 had no correlation with tumour size, and lymph node status. CONCLUSIONS: PD-L1 expression may not be an independent predictor of prognosis of patients with OSCC. Well-designed large cohort studies are needed to confirm these findings.

Key words: OSCC, PD-L1, HPV, PD-1, Meta analysis

中图分类号:

R739.8

邹波, 许凯, 刘宪斌, 范庆春, 刘建林, 袁道英. PD-L1的表达与口腔鳞癌预后及临床病理特征相关性的meta分析[J]. 上海口腔医学, 2018, 27(1): 100-105.

ZOU Bo, XU Kai, LIU Xian-bin, FAN Qing-chun, LIU Jian-lin, YUAN Dao-ying. Clinicopathological and prognostic significance of PD-L1 expression in oral squamous cell carcinoma: a meta analysis[J]. Shanghai Journal of Stomatology, 2018, 27(1): 100-105.

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