超声热化疗联合根治性手术治疗晚期口腔鳞癌的有效性和安全性评价

doi:10.19439/j.sjos.2017.02.022

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (2): 233-236.doi: 10.19439/j.sjos.2017.02.022

超声热化疗联合根治性手术治疗晚期口腔鳞癌的有效性和安全性评价

邵翠玲^1,2, 庄乾伟¹, 孟箭^1*, 郭伟^3*, 任国欣², 张杰¹, 顾倩平¹, 李志萍¹, 王兴¹, 辜健敏¹, 韩琨¹

1.徐州市中心医院口腔科,江苏徐州 221009;
2.潍坊医学院口腔医学院,山东潍坊 261000;
3.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,上海 200011

收稿日期:2016-06-12 修回日期:2016-09-25 出版日期:2017-04-25 发布日期:2017-05-04
通讯作者: 孟箭,E-mail:mrocket@126.com;郭伟,E-mail：guoweicn@yahoo.com。^*共同通信作者
作者简介:邵翠玲（1990-）,女,在读硕士研究生,E-mail：1355307679@qq.com
基金资助:
上海市科学技术委员会科研计划项目（14DZ1941400）; 徐州市科技计划项目（KC14SH028）

Safety and efficacy of ultrasound hyperthermia combined with chemotherapy and radical operation for advanced oral squamous cell carcinoma

SHAO Cui-ling^1,2, ZHUANG Qian-wei¹, MENG Jian¹, GUO Wei³, REN Guo-xin¹, ZHANG Jie¹, GU Qian-ping¹, LI Zhi-ping¹, WANG Xing¹, GU Jian-min¹, HAN Kun¹

1.Department of Stomatology, Xuzhou Central Hospital. Xuzhou 221009, Jiangsu Province;
2.School of Stomatology, Weifang Medical College. Weifang 261000, Shandong Province;
3.Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China

Received:2016-06-12 Revised:2016-09-25 Online:2017-04-25 Published:2017-05-04

摘要/Abstract

摘要： 目的: 评价超声热化疗联合根治性手术治疗晚期口腔鳞癌的安全性及可行性。方法: 对2015—2016年就诊的9例经明确病理诊断的口腔鳞癌患者行术前超声热化疗。TPF具体方案为d1：顺铂+多西他赛75 mg/m²,静脉滴注;d1~d5：5氟尿嘧啶750 mg/m²,静脉滴注。超声热化疗期间,于化疗开始的第1、3、5、7、9天行超声肿瘤热疗,温度控制在40~42℃,热疗时间为40 min。每例患者行2周期超声热化疗,评价肿瘤局部消退情况。结果: 完全缓解1例,部分缓解3例,稳定5例。超声热化疗期间无明显严重不良反应。患者面形及功能保存较好,生存质量有所提高。结论: 超声热疗联合TPF化疗方案治疗晚期口腔鳞癌具有协同作用,可提高患者的近期疗效,不良反应较轻,患者可耐受,是一种微创、有效、安全性高的治疗方案。

关键词: 超声, 热疗, 化疗, 口腔鳞癌

Abstract: PURPOSES: To explore the safety and efficacy of ultrasound hyperthermia combined with chemotherapy and radical operation for advanced oral squamous cell carcinoma (OSCC). METHODS: Nine patients who had definite pathological diagnosis were enrolled in this clinical trail from 2015 to 2016. All patients underwent ultrasound hyperthermia combined with chemotherapy before radical operation. The treatment regime was as follows: Docetaxel and cisplatin (75mg/m²) used on the first day, fluorouracil (750 mg/m²) infused from 1st to 5th day. All patients received 2 cycles of thermo-chemotherapy, the therapeutic temperature was set to be 40-42 ℃, ultrasound hyperthermia was performed for 40 minutes every other day for 5 times. The therapeutic outcomes were evaluated by observation of clinical tumor regression. RESULTS: Of the 9 patients, complete response（CR）was seen in 1 case, partial response (PR) was seen in 3 cases, stable disease（SD）was seen in 5 cases. Complications were not severe and tolerable. CONCLUSIONS: Ultrasound hyperthermia combined with chemotherapy (TPF) may improve the therapeutic effect in advanced OSCC without obvious adverse reactions, and the toxicity and side effects are well tolerated.

Key words: Ultrasound, Hyperthermia, Chemotherapy, Oral squamous cell carcinoma

中图分类号:

R739.8

邵翠玲, 庄乾伟, 孟箭, 郭伟, 任国欣, 张杰, 顾倩平, 李志萍, 王兴, 辜健敏, 韩琨. 超声热化疗联合根治性手术治疗晚期口腔鳞癌的有效性和安全性评价[J]. 上海口腔医学, 2017, 26(2): 233-236.

SHAO Cui-ling, ZHUANG Qian-wei, MENG Jian, GUO Wei, REN Guo-xin, ZHANG Jie, GU Qian-ping, LI Zhi-ping, WANG Xing, GU Jian-min, HAN Kun. Safety and efficacy of ultrasound hyperthermia combined with chemotherapy and radical operation for advanced oral squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2017, 26(2): 233-236.

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超声热化疗联合根治性手术治疗晚期口腔鳞癌的有效性和安全性评价

Safety and efficacy of ultrasound hyperthermia combined with chemotherapy and radical operation for advanced oral squamous cell carcinoma

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