The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma

doi:10.19439/j.sjos.2024.02.007

Abstract

Abstract: PURPOSE: The purpose of this study was to explore the expression, prognostic value and immune correlation of Cofilin 1 protein(CFL-1) in head and neck squamous cell carcinoma(HNSCC). METHODS: The expression and prognostic value of CFL-1 in head and neck squamous cell carcinoma(HNSCC) was explored in the cancer genome map database (TCGA) and gene expression total databases (GEO), and the potential immune pathway of CFL-1 in HNSCC was revealed by GESA and cibersoft analysis. The data were statistically analyzed using SPSS 26.0 software package. RESULTS: CFL-1 was significantly up-regulated in HNSCC tissue. The expression level of CFL-1 was significantly correlated with the overall survival status of HNSCC. High expression of CFL-1 was significantly associated with a lower overall survival rate. In addition, multivariate Cox survival analysis showed that CFL-1 expression was independent predictors of poor prognosis of HNSCC. GESA and cibersoft analysis showed that the imbalance of CFL-1 expression affected multiple signal pathways and infiltration of immune cells. CONCLUSIONS: CFL-1 is highly expressed in HNSCC and is significantly associated with poor prognosis of NHSCC. It is a potential prognostic marker of HNSCC.

Key words: CFL-1, Head and neck squamous cell carcinoma, Immune infiltration, Prognosis, Marker

CLC Number:

R739.8

ZHAO Kai, ZHANG Yu-ning, JI Shuai-qi, LIU Ying, JIANG Han. The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2024, 33(2): 148-155.

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