Vascularized fibula flap reconstruction of the mandible defect resulting from bisphosphonate-related osteonecrosis of the jaws: case report and literature

Shanghai Journal of Stomatology ›› 2015, Vol. 24 ›› Issue (5): 474-477.

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Vascularized fibula flap reconstruction of the mandible defect resulting from bisphosphonate-related osteonecrosis of the jaws: case report and literature

review GUO Yu-xing, WANG Dian-can, WANG Yang, PENG Xin, GUO Chuan-bin, MAO Chi.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology. Beijing 100081, China

Received:2014-12-30 Revised:2015-02-20 Online:2015-10-20 Published:2015-11-03
Supported by:
Supported by Scientific Research Fund for Youth of Peking University School and Hospital of Stomatology(PKUSS20140103).

Abstract

Abstract: Bisphosphonates have been used in clinic for over 30 years as a potent of bone resorption inhibitors, which are widely prescribed in diseases related to bone turnover change. In recent years, many authors found that long-term application of bisphosphonates can lead to osteonecrosis of the jaws. The treatment proposal has not reached consensus, including conservative treatment, surgical curettage and bone resection (reconstruction or without reconstruction). This paper reported a case with mandibular defect resulting from bisphosphonate related osteonecrosis of the jaws, repaired with vascularized fibular flap subsequently. The final functional and aesthetic outcomes were satisfied.

Key words: Bisphosphonates, Jaws, Osteonecrosis

review GUO Yu-xing, WANG Dian-can, WANG Yang, PENG Xin, GUO Chuan-bin, MAO Chi. Vascularized fibula flap reconstruction of the mandible defect resulting from bisphosphonate-related osteonecrosis of the jaws: case report and literature[J]. Shanghai Journal of Stomatology, 2015, 24(5): 474-477.

References

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Vascularized fibula flap reconstruction of the mandible defect resulting from bisphosphonate-related osteonecrosis of the jaws: case report and literature

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