Abstract: PURPOSE: To investigate the 2-year results of pit and fissure sealant in 457 children in Uygur city for caries prevention in the first permanent molars. METHODS: One thousand four hundred and ninety-nine newly erupted first permanent molars in 457 children between the ages of 7 and 9 in Uygur city underwent pit and fissure sealing using 3M Concisse sealant. The retention of sealants 6, 12 and 24 months after sealing was observed and the caries occurrence were recorded. The data was analyzed with SPSS 16.0 software package. RESULTS: The retention rate of pit and fissure sealant 6, 12 and 24 months after sealing was 98.33%, 92.71% and 88.93%, respectively. The frequency of dental caries was 0%, 0.63% and 1.15% respectively, which were significantly reduced compared with the average prevalence in China (P<0.05). CONCLUSIONS: Pit and fissure sealant is safe and effective in preventing dental decay in first permanent molar in Uygur children, which is worthy of wide clinical application.

Key words: Pit and fissure sealant, First permanent molars, Dental caries, Prevention