Abnormal expression of CytC in the labial gland of patients with primary Sj?gren’s syndrome

Abstract

Abstract: PURPOSE: To explore the expression of CytC in the labial glands of patients with primary Sj?gren’s syndrome(pSS). METHODS: Thirty-five cases with pSS and 15 controls were collected. Immunohistochemistry and RT-PCR were used to examine CytC protein and mRNA in labial glands of 2 groups. The integral optical density were measured and the data was analyzed by Mann-Whitney test with SPSS14.0 software package. The correlation between the clinical manifestations and the expression of CytC were calculated by Spearman’s analysis. RESULTS: The expression of CytC protein and mRNA in pSS were positively correlated with the disease course and significantly higher than those in control group (P<0.05). There was a positive correlation between the lymphocyte focus score and the expression of CytC, but no correlation with the other clinical parameters. CONCLUSIONS: The expression of CytC in pSS is increased,which is related to the disease course and the lymphocyte focus score.

Key words: Sj?gren’s syndrome, Labial gland, Apoptosis, CytC

CLC Number:

R781.7

KANG Yuan-yuan, ZHANG Ying. Abnormal expression of CytC in the labial gland of patients with primary Sj?gren’s syndrome[J]. Shanghai Journal of Stomatology, 2013, 22(6): 680-683.

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