Ultrasonographic features of Castleman disease in the head and neck: a report of 7 cases

doi:10.19439/j.sjos.2024.03.021

Abstract

Abstract: PURPOSE: To summarize the ultrasonographic features of head and neck Castleman disease (CD), and to clarify its diagnostic key points. METHODS: Seven patients with head and neck CD confirmed by histopathology were collected from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. The clinical features and ultrasound findings of the patients were evaluated. RESULTS: Of the 7 patients (1 male and 6 females), the mean age at diagnosis was 31.4 years (7-60 years). All the cases were hyaline vascular type. On ultrasound, 3 lesions (42.9%) were located in the parotid gland, 4 lesions(57.1%) in the neck. All the lesions presented as a solitary, well-defined and solid mass without calcification. The echogenicity was markedly hypoechoic in 1 case(14.3%) and hypoechoic in 6 cases (85.7%). Of the 7 CD cases, 4 cases (57.1%) were heterogeneous masses with linear echogenic septa. All lesions had mixed pattern in vascularity on color Doppler sonography. CONCLUSIONS: Most CDs in the head and neck represent as a markedly hypoechoic or hypoechoic lesion with mixed pattern in vascularity. The neoplasm may be characterized by the presence of linear echogenic septa within the mass.

Key words: Castleman disease, Head and neck region, Ultrasound

CLC Number:

R739.8

ZHOU Hui-hong, CHEN Qian-qian, YUAN Fang, SUN Jing-jing, TIAN Zhen, XIONG Ping. Ultrasonographic features of Castleman disease in the head and neck: a report of 7 cases[J]. Shanghai Journal of Stomatology, 2024, 33(3): 328-331.

References

[1] Dispenzieri A, Fajgenbaum DC.Overview of Castleman disease[J]. Blood, 2020, 135(16): 1353-1364.
[2] Cronin DM, Warnke RA.Castleman disease: an update on classification and the spectrum of associated lesions[J]. Adv Anat Pathol, 2009, 16(4): 236-246.
[3] 石梦晗, 刘婉莹, 余莉. Castleman病的临床病理特征及可能的发病机制[J]. 中国肿瘤临床, 2020, 47(13): 677-681.
[4] Haap M, Wiefels J, Horger M, et al.Clinical, laboratory and imaging findings in Castleman's disease-the subtype decides[J]. Blood Rev, 2018, 32(3): 225-234.
[5] Ko SF, Hsieh MJ, Ng SH, et al.Imaging spectrum of Castleman's disease[J]. AJR Am J Roentgenol, 2004, 182(3): 769-775.
[6] Som PM, Curtin HD, Mancuso AA.An imaging-based classification for the cervical nodes designed as an adjunct to recent clinically based nodal classifications[J]. Arch Otolaryngol Head Neck Surg, 1999, 125(4): 388-396.
[7] Ahuja A, Ying M, King A, et al.Lymph node hilus: gray scale and power Doppler sonography of cervical nodes[J]. J Ultrasound Med, 2001, 20(9): 987-992.
[8] He X, Wang Q, Wu Y, et al.Comprehensive analysis of 225 Castleman's diseases in the oral maxillofacial and neck region: a rare disease revisited[J]. Clin Oral Investig, 2018, 22(3): 1285-1295.
[9] Frizzera G.Castleman's disease and related disorders[J]. Semin Diagn Pathol, 1988, 5(4): 346-364.
[10] 伍君, 伍希, 肖旭平, 等. 头颈部Castleman病临床特点分析[J]. 中国耳鼻咽喉头颈外科, 2021, 28(4): 254-256.
[11] Mahmood N, Suresh HB, Swethadri GK, et al.Ultrasound and Doppler findings in a rare case of Castleman's disease of the parotid[J]. Dentomaxillofac Radiol, 2010, 39(1): 54-56.
[12] Choi HJ, Lee JH, Lee YM, et al.Castleman disease of parotid gland[J]. J Craniofac Surg, 2016, 27(5): 1373-1374.
[13] 轩维锋. 颈部局限型Castleman病的超声表现[J]. 国际医学卫生导报, 2011, 17(23): 2884-2887.
[14] Poyanli A, Genc FA, Sencer S, et al.Cervical Castleman's disease: imaging findings[J]. Eur Radiol, 2000, 10(7): 1190-1192.
[15] Zhou W, Zhan W, Zhou J, et al.Sonographic findings of localized Castleman disease of the abdomen and pelvis[J]. J Clin Ultrasound, 2015, 43(7): 401-405.
[16] Lee YY, Wong KT, King AD, et al.Imaging of salivary gland tumours[J]. Eur J Radiol, 2008, 66(3): 419-436.
[17] 赵瑞娜, 张波, 姜玉新. 颈部转移性淋巴结的超声评估[J]. 中国医学科学院学报, 2012, 34(6): 633-639.
[18] 石文媛, 夏春霞, 周亚静, 等. 超声对颈动脉体瘤的诊断价值[J]. 中国耳鼻咽喉头颈外科, 2015, 22(6): 293-295.
[19] Yang F, Chen XX, Wu HL, et al.Sonographic features and diagnosis of peripheral schwannomas[J]. J Clin Ultrasound, 2017, 45(3): 127-133.
[20] 张旭, 刘丹, 黄品同. 多模态超声在颈部淋巴瘤诊断中的价值[J]. 中华医学超声杂志(电子版), 2020, 17(10): 987-992.
[21] 苟加梅, 陈琴, 周青, 等. 唾液腺Warthin瘤超声特征与病理对照分析[J]. 华西口腔医学杂, 2013, 31(4): 389-392.
[22] Orita Y, Sato Y, Kimura N, et al.Characteristic ultrasound features of mucosa-associated lymphoid tissue lymphoma of the salivary and thyroid gland[J].Acta Otolaryngol, 2014, 134(1): 93-99.