Clinical effect of MB-PDT assisted initial therapy on alveolar angle absorption of lower anterior teeth

doi:10.19439/j.sjos.2024.03.009

Abstract

Abstract: PURPOSE: To evaluate the effect of MB-PDT assisted essential therapy on angle resorption of lower anterior alveolar bone in patients with periodontitis. METHODS: Forty patients who were diagnosed with periodontitis stage III-IV or C, lower anterior teeth alveolar bone angle resorption, and periodontal pocket depth greater than 4 mm were selected from April 2018 to October 2020 in the Department of Periodontology and Oral Mucosal Diseases, Changsha Stomatological Hospital. The patients were randomly divided into control group and experimental group with 20 cases in each group. Compared with the control group which was only managed with essential treatment, the experimental group was treated with MB-PDT on the basis of the control group. The plaque index (PLI) and gingival bleeding index (GBI) scores of the two groups were recorded before surgery and 1 and 2 weeks after surgery. Probing depth (PD) and clinical attachment level (CAL) were detected before and 6 months after surgery. Statistical analysis of the data was performed using Graphpad Prism 5 software package. RESULTS: The PLI and GBI of the experimental group were significantly lower than those of the control group at 1 and 2 weeks after operation(P<0.05). Six months after surgery, PD and CAL levels in the experimental group were significantly lower than those in the control group (P<0.05). CONCLUSIONS: MB-PDT adjuvant therapy has the advantages of simple operation, efficient sterilization, promotion of healing, and high safety performance. It may be a new non-surgical adjuvant treatment strategy for effective treatment of lower anterior alveolar angular resorption.

Key words: Methylene blue, Photodynamic therapy, Essential therapy, Periodontitis, Angular absorption of alveolar bone

CLC Number:

R781.4

BU Xiao-shuang, WANG Xiao, PAN Tiao-hua, ZHU Li-lei, Guo Jin-cai. Clinical effect of MB-PDT assisted initial therapy on alveolar angle absorption of lower anterior teeth[J]. Shanghai Journal of Stomatology, 2024, 33(3): 265-268.

References

[1] 范雅丹, 束蓉, 程岚, 等. 光动力疗法辅助治疗Ⅲ期、Ⅳ期牙周炎的临床效果评价[J]. 上海口腔医学, 2022, 31(5): 501-506.
[2] Assem NZ, Alves MLF, Lopes AB, et al.Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis[J]. Braz Oral Res,2017, 31: e67.
[3] Tonetti MS, Greenwell H, Kornman KS.Staging and grading of periodontitis: Framework and proposal of a new classification and case definition[J]. J Clin Periodontol, 2018, 89(Suppl 1): S159-S172.
[4] Dalvi SA, Hanna R, Gattani DR.Utilisation of antimicrobial photodynamic therapy as an adjunctive tool for open flap debridement in the management of chronic periodontitis: a randomized controlled clinical trial[J]. Photodiagnosis Photodyn Ther, 2019, 25: 440-447.
[5] Cortellini P, Tonetti MS.Clinical concepts for regenerative therapy in intrabony defects[J]. Periodontol 2000, 2015, 68(1): 282-307.
[6] Chapple ILC, Mealey BL, Van Dyke TE, et al.Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions[J]. J Periodontol, 2018, 89(Suppl 1): S74-S84.
[7] Lang NP, Bartold PM.Periodontal health[J]. J Periodontol, 2018, 89(Suppl 1): S9-S16.
[8] 陆卫青, 张炜亮, 向文静, 等. 牙周内镜辅助牙周非手术治疗对牙龈退缩的影响[J]. 上海口腔医学, 2022, 31(4): 435-438.
[9] 冯希平. 口腔预防医学[M](7版). 北京: 人民卫生出版社,2020: 22-36.
[10] 裴喜燕, 孙凤. 微创牙周非手术治疗研究进展[J]. 口腔医学研究, 2020, 36(7): 622-625.
[11] Sculean A, Aoki A, Romanos G, et al.Is photodynamic therapy an effective treatment for periodontal and peri-implant infections?[J]. Dent Clin North Am, 2015, 59(4): 831-858.
[12] Baptista MS, Cadet J, Di Mascio P, et al.Type I and type II photosensitized oxidation reactions: guidelines and mechanistic pathways[J]. Photochem Photobiol, 2017, 93(4): 912-919.
[13] Etemadi A, Hamidain M, Parker S, et al.Blue light photodynamic therapy with curcumin and riboflavin in the management of periodontitis: a systematic review[J]. J Lasers Med Sci, 2021, 12: e15.
[14] Zhao Y, Pu R, Qian Y, et al.Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the treatment of periodontitis and peri-implantitis: a systematic review and meta-analysis[J]. Photodiagnosis Photodyn Ther, 2021, 34: 102231.
[15] 于丽丽, 吕成奇, 林宗建, 等. 光动力疗法与二极管激光辅助治疗牙周病疗效的临床随机对照研究[J]. 哈尔滨医科大学学报, 2019, 53(1): 74-79.
[16] 栾秀玲, 胡艳秋, 秦艳利. 甲苯胺蓝为光敏剂的光动力疗法对龈下菌斑灭菌效果的研究[J].口腔医学研究, 2012, 28(3): 233-236.
[17] 刘明军, 宋莉, 邹海啸, 等. 光动力抗菌疗法治疗牙周炎的研究进展[J]. 中国激光医学杂志, 2017, 26(4): 210-215.
[18] Alvarenga LH, Prates RA, Yoshimura TM, et al.Aggregatibacter actinomycetemcomitans biofilm can be inactivated by methylene blue-mediated photodynamic therapy[J]. Photodiagnosis Photodyn Ther, 2015, 12(1): 131-135.
[19] 付兆江, 吴迎涛, 韩晓虹. 超级粘接剂在松牙固定中的应用探讨[J]. 全科口腔医学电子杂志, 2015, 2(8): 108-111.