Effect of toothpaste containing emulsifier 30 and sodium lauryl sulfate surfactant on the integrity of oral epithelium

doi:10.19439/j.sjos.2021.03.018

Abstract

Abstract: PURPOSE: To investigate the effect of toothpaste containing emulsifier 30 and sodium lauryl sulfate surfactant on the integrity of oral epithelium. METHODS: Sixty individuals equally divided into 2 groups by random number table methods. Group A received toothpaste containing emulsifier 30, while group B received fluoride toothpaste containing sodium lauryl sulfate (SLS) surfactant. The exfoliation of oral soft tissue was evaluated before, 30 minutes and 4 days after the test. The fluoride concentration in plaque and saliva was compared between the two groups. The data were processed with SPSS 22.0 software package. RESULTS: The scores of oral soft tissue exfoliation at 30 min and 4 d after the test were increased significantly (P<0.05). The scores of subgingival, supragingival, oral apex and oral soft tissue exfoliation of group A at 30 min after using the paste were significantly lower than those 4 days after using the paste(P<0.05), while no significant change was observed in the score of oral soft tissue exfoliation at the dorsal tongue(P>0.05). The total scores of subgingival, supragingival, dorsal tongue, ventral tongue and oral soft tissue exfoliation in group B 30 min after using the paste were significantly higher than those at 4 d after use, and the score of oral soft tissue exfoliation at oral apex was significantly lower than that at 4 d after use (P<0.05).The total scores of subgingival, supragingival, dorsal tongue, ventral tongue and oral soft tissue exfoliation in group B at 30 min after using the paste were significantly higher than those of group A, while the score of oral soft tissue exfoliation at oral apex was significantly lower than that of group A(P<0.05).The total scores of subgingival, supragingival, ventral tongue and oral soft tissue exfoliation in group B at 4 d after using the paste were significantly higher than those of group A(P<0.05). The scores of oral soft tissue exfoliation at oral apex and dorsal tongue at 4 d after use had no significant difference between the two groups (P>0.05). The fluoride concentration in plaque and saliva was increased significantly in both groups after test(P<0.05). CONCLUSIONS: Both fluoride toothpaste containing emulsifier 30 and SLS surfactant cause a certain degree of oral soft tissue exfoliation. In comparison, fluoride toothpaste containing emulsifier 30 has less oral soft tissue damage; moreover, the two fluoride toothpastes can effectively inhibit acid production of plaque bacteria and prevent occurrence of caries.

Key words: Emulsifier 30, Sodium lauryl sulfate, Toothpaste, Oral epithelium, Integrity

CLC Number:

R780.1

YANG Mei, ZHAO Hai-ping, YANG Jie. Effect of toothpaste containing emulsifier 30 and sodium lauryl sulfate surfactant on the integrity of oral epithelium[J]. Shanghai Journal of Stomatology, 2021, 30(3): 312-315.

References

[1] 张冬梅, 徐婉悦, 潘佳雨, 等. 白色念珠菌侵入口腔黏膜上皮体外模型的构建[J]. 实用口腔医学杂志, 2018, 34(5): 606-609.
[2] 王彦昊, 廖彬佑, 史晓扬, 等. 重庆市3类人群对含氟牙膏认知和使用情况的调查研究[J]. 重庆医学, 2019,48(14): 2443-2446, 2450.
[3] 郜洪宇, 孟焕新, 侯建霞. S100A8/A9蛋白与牙周炎症性疾病关系的研究进展[J]. 中华口腔医学杂志, 2020, 55(9): 679-684.
[4] 米娅莎尔·呼加合买提, 李雪, 吕慧欣, 等. 槲皮素对人口腔上皮细胞再生的生物学效应研究[J]. 口腔医学研究, 2018, 11(9): 991-994.
[5] Adami GR, Tangney CC, Tang JL, et al.Effects of green tea on miRNA and microbiome of oral epithelium[J]. Sci Rep, 2018, 8(1): 5870-5873.
[6] 任肖华, 王晓洁, 万荣, 等. 口腔健康知识强化教育管理对新兵口腔健康素养影响观察[J]. 人民军医, 2020,10(5): 427-429.
[7] 陈谦明. 口腔黏膜病学[M]. 北京: 人民卫生出版社, 2012.
[8] Tadin A, Gavic L, Zeravica A, et al.Assessment of cytotoxic and genotoxic effects of conventional and whitening kinds of toothpaste on oral mucosa cells[J]. Acta Odontol Scand, 2018, 76(1): 64-70.
[9] 张莹, 张泽标, 陈巧凤, 等. 唑来膦酸脂质体抑制口腔上皮癌KB细胞增殖的研究[J]. 中国临床药理学杂志, 2018, 34(19): 2309-2312.
[10] 王君玲, 邵苗苗, 何建亚,等. 血小板中生长因子在口腔种植中促进软组织与硬组织愈合的效应[J]. 中国组织工程研究, 2018, 22(20): 3250-3255.
[11] 孙群. 十二烷基硫酸钠(K12)质量对牙膏稳定性的影响[J]. 牙膏工业, 1999, 13(4): 23-25.
[12] Altan H, Göztas Z, Kahraman K, et al.Inhibition effects of different toothpastes on demineralisation of incipient enamel lesions[J]. Oral Health Prev Dent, 2019, 17(2): 179-185.
[13] Wang Y, Mei L, Gong L, et al.Remineralization of early enamel caries lesions using different bioactive elements containing toothpastes: an in vitro study[J]. Technol Health Care, 2016, 24(5): 701-711.
[14] Nersesyan A.Re: in vivo evaluation of fluoride and sodium lauryl sulphate in toothpaste on buccal epithelial cells toxicity[J]. Acta Odontol Scand, 2019, 77(7): 559-568.
[15] Cheng L, Liu W, Zhang T, et al.Evaluation of the effect of a toothpaste containing Pudilan extract on inhibiting plaques and reducing chronic gingivitis: a randomized, double-blinded, parallel controlled clinical trial[J]. J Ethnopharmacol,2019,240:111870.